Piperinox

Piperinox – Ingredients

• Guarana Seed Extract [22% Caffeine] (Paullinia Cupana)
  • Guarana Seed (Paullinia Cupana)
    A popular energy supplement, Guarana Extract offers one of the highest concentrations of caffeine among any plant. In fact, it can contain up to 3.6 to 5.8% caffeine by weight whereas coffee has only up to 2%. It has a stimulating effect. Supports lipid metabolism. Species: Paullinia Cupana,
    Family: Sapindaceae,
    European Medicines Agency: EMA: Paulliniae Semen,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH29CF20,
    References:
    Weight Loss: ALKHATIB, Ahmad; SEIJO, M.; LARUMBE, E.; NACLERIO, F. Acute effectiveness of a “fat-loss” product on substrate utilization, perception of hunger, mood state and rate of perceived exertion at rest and during exercise. Journal of the International Society of Sports Nutrition, 2015, 12.1: 44. PMID:26612980.
    
    
  • Caffeine (C₈H₁₀N₄O₂)
    天然無水カフェイン – 集中力と持久力を高め、運動後の疲労感を最小限に抑えます。
    Caffeine: Caffeine, 1,3,7-Trimethylxanthine, Thein,
    PubChem CID: 2519,
    Chemical Abstracts Service: CAS: 58-08-2,
    ChemIDplus: 58-08-2,
    WHO Anatomical Therapeutic Chemical Classification System: ATC code: N06BC01,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS2C8E40,
    References:
    Weight Loss: TABRIZI, R.; SANEEI, P.; LANKARANI, K. B.; AKBARI, M.; KOLAHDOOZ, F.; ESMAILLZADEH, A.; NADI-RAVANDI, S.; MAZOOCHI, M.; ASEMI, Z. The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials. Critical reviews in food science and nutrition, 2018, 2018: 1-9. PMID:30335479, SMITH, Andrew Effects of caffeine on human behavior. Food and chemical toxicology, 2002, 40.9: 1243-1255. PMID:12204388.
    
• Cinnamon Bark Extract (Cinnamomum Cassia)
  • Chinese Cinnamon (Cinnamomum Cassia)
    Cinnamon Bark Extract: helps maintain a healthy blood sugar level, facilitates weight control, improves digestive comfort. Species: Cinnamomum Cassia,
    Family: Lauraceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IHAA97E0,
    References:
    Weight Loss: ABDALI, Daniyal; SAMSON, Sue E.; GROVER, Ashok Kumar How Effective Are Antioxidant Supplements in Obesity and Diabetes?. Medical Principles and Practice, 2015, 24.3: 201-215. PMID:25791371.
    
    
• Bitter Orange Fruit Extract [6% Synephrine] (Citrus Aurantium)
  • Bitter Orange (Citrus Aurantium)
    黒胡椒果実エキス – 消化液の分泌を助け、栄養素の吸収を高め、お通じをよくします。 Species: Citrus Aurantium,
    Family: Rutaceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2932E0,
    References:
    Weight Loss: PREUSS, Harry G.; DIFERDINANDO, D.; BAGCHI, D. Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview. Journal of medicine, 2002, 33.1-4: 247-264. PMID:12939122, COLKER, Carlon M.; DIFERDINANDO, D.; BAGCHI, D. Effects of Citrus aurantium extract, caffeine, and St. John’s wort on body fat loss, lipid levels, and mood states in overweight healthy adults. Current Therapeutic Research, 1999, 60.3: 145-153..
    
    
  • Synephrine (C₉H₁₃NO₂)
    Synephrine: Synephrine, Oxedrine, P-Synephrine, Parasympatol,
    PubChem CID: 7172,
    Chemical Abstracts Service: CAS: 94-07-5,
    ChemIDplus: 94-07-5,
    WHO Anatomical Therapeutic Chemical Classification System: ATC code: C01CA08,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS37FFF0,
    References:
    Weight Loss: STOHS, Sidney J.; PREUSS, H. G.; SHARA, M. A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. International journal of medical sciences, 2012, 9.7: 527. PMID:22991491, STOHS, Sidney J. Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p‐Synephrine. Phytotherapy research, 2017, 31.10: 1463-1474. PMID:28752649.
    
• Ginger Rhizomes Extract [5% Gingerols] (Zingiber Officinale)
  • Ginger Rhizomes (Zingiber Officinale)
    Ginger root extract reduces appetite, stimulates the production of gastric juice, facilitates recovery in many gastrointestinal diseases (accelerates metabolism, prevents further weight gain). Ginger Rhizomes Extract: supports the functioning of the immune system, has an antioxidant effect, supports the absorption of nutrients, it lowers the blood sugar level, supports carbohydrate metabolism. Species: Zingiber Officinale,
    Family: Zingiberaceae,
    European Medicines Agency: EMA: Zingiberis Rhizoma,
    Domain: Plantae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2959F0,
    References:
    Weight Loss: MAHARLOUEI, Najmeh; TABRIZI, R.; LANKARANI, K. B.; REZAIANZADEH, A.; AKBARI, M.; KOLAHDOOZ, F.; RAHIMI, M.; KENESHLOU, F.; ASEMI, Z. The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials. Critical reviews in food science and nutrition, 2018, 2018: 1-14. PMID:29393665, TAGHIZADEH, Mohsen; FARZIN, N.; TAHERI, S.; MAHLOUJI, M.; AKBARI, H.; KARAMALI, F.; ASEMI, Z. The effect of dietary supplements containing green tea, capsaicin and ginger extracts on weight loss and metabolic profiles in overweight women: A randomized double-blind placebo-controlled clinical trial. Annals of Nutrition and Metabolism, 2017, 70.4: 277-285. PMID:28595182.
    
    
  • Gingerol (C₁₇H₂₆O₄)
    Gingerol: Gingerol, 6-Gingerol,
    PubChem CID: 442793,
    Chemical Abstracts Service: CAS: 23513-14-6,
    ChemIDplus: 23513-14-6,
    FDA Substance Registration System – Unique Ingredient Identifier: UNII: 925QK2Z900,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS37D8E0.
    
• Cayenne Pepper Fruit Extract [10% Capsaicin] (Capsicum Annuum L.)
  • Cayenne Pepper (Capsicum Annuum)
    アシュワガンダ根エキス – 体重コントロールを助け、エネルギーアップ作用があります。 Species: Capsicum Annuum,
    Family: Solanaceae,
    European Medicines Agency: EMA: Capsici Fructus,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH298100,
    References:
    Weight Loss: WHITING, Stephen; DERBYSHIRE, Emma; TIWARI, B. K. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite, 2012, 59.2: 341-348. PMID:22634197, VARGHESE, Sharon; et al. Chili pepper as a body weight-loss food. International journal of food sciences and nutrition, 2017, 68.4: 392-401. PMID:27899046.
    
    
  • Capsaicin (C₁₈H₂₇NO₃)
    Capsaicin: Capsaicin, Zostrix, Capsaicine, Transacin,
    PubChem CID: 1548943,
    Chemical Abstracts Service: CAS: 404-86-4,
    ChemIDplus: 404-86-4,
    WHO Anatomical Therapeutic Chemical Classification System: ATC code: M02AB01,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS39FBC0,
    References:
    Weight Loss: WHITING, Stephen; DERBYSHIRE, Emma; TIWARI, B. K. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite, 2012, 59.2: 341-348. PMID:22634197, TAGHIZADEH, Mohsen; FARZIN, N.; TAHERI, S.; MAHLOUJI, M.; AKBARI, H.; KARAMALI, F.; ASEMI, Z. The effect of dietary supplements containing green tea, capsaicin and ginger extracts on weight loss and metabolic profiles in overweight women: A randomized double-blind placebo-controlled clinical trial. Annals of Nutrition and Metabolism, 2017, 70.4: 277-285. PMID:28595182.
    
• Black Pepper Fruit Extract – BioPerine® [95% Piperine] (Piper Nigrum L.)
  • BioPerine®
    BioPerine® is an innovative form of piperine devoid of chemicals used for growing plants such as: fertilizers, concentrates, nutrients, pesticides or other plant protection products. The safety of its use has been confirmed by the European Food Safety Authority (EFSA). Thanks to better absorption, in comparison to the conventional form, and the use of this form, a significant increase in bioavailability of other valuable components of this supplement is observed. This even leads to a 30-fold increase in its effects. In addition, BioPerine® contains more piperine than black pepper extract, which further intensifies the effectiveness of the product.
    BioPerine®: BioPerine®,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS28E4C0.
    
  • Black Pepper (Piper Nigrum)
    トウガラシ抽出物 – 体重管理を可能にし消化器系を正常に保ちます Species: Piper Nigrum,
    Family: Piperaceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2CB550,
    References:
    Weight Loss: TAKOOREE, Heerasing; AUMEERUDDY, M. Z.; RENGASAMY, K. R. R.; VENUGOPALA, K. N.; JEEWON, R.; ZENGIN, G.; MAHOMOODALLY, M. F. A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications. Critical reviews in food science and nutrition, 2019, 2019: 1-34. PMID:30740986, MUJUMDAR, Arvind Manohar; DHULEY, Jayant Nilkanth; DESHMUKH, Vinaykumar Keshav; RAMAN, Palghat Hariharan; NAIK, Suresh Ramnath Anti-inflammatory activity of piperine. Japanese Journal of Medical Science and Biology, 1990, 43.3: 95-100. PMID:2283727.
    
    
  • Piperine (C₁₇H₁₉NO₃)
    Piperine: Piperine, Bioperine, Piperin, 1-Piperoylpiperidine, Piperoylpiperidine, 1-Piperylpiperidine,
    PubChem CID: 638024,
    Chemical Abstracts Service: CAS: 94-62-2,
    ChemIDplus: 94-62-2,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS395F80,
    References:
    Weight Loss: NOGARA, Leonardo; et al. Piperine’s mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle. Proceedings of the National Academy of Sciences, 2016, 113.46: 13009-13014. PMID:27799519.
    
• Chromium (chromium picolinate) (C₁₈H₁₂CrN₃O₆)
  クロム – 正常な血中グルコースレベルを維持し、マクロ栄養素の代謝に影響を与えます
  Chromium (chromium picolinate): Chromium Picolinate, Picolinic Acid Chromium(III) Salt, Chromium(III) Picolinate,
  PubChem CID: 151932,
  Chemical Abstracts Service: CAS: 14639-25-9,
  ChemIDplus: 14639-25-9,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS29A810-1,
  References:
  Weight Loss: PITTLER, M. H.; STEVINSON, C.; ERNST, E. Chromium picolinate for reducing body weight: meta-analysis of randomized trials. International journal of obesity, 2003, 27.4: 522. PMID:12664086, DOCHERTY, John P.; SACK, D. A.; ROFFMAN, M.; FINCH, M.; KOMOROWSKI, J. R. A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving. Journal of Psychiatric Practice®, 2005, 11.5: 302-314. PMID:16184071.
  

Recommended intake of this supplement: 1 capsule, daily (adults).