What are the properties of Synephrine in supplements?

The Supplements with SynephrineThe Supplements with Synephrine

The properties of Synephrine

Synephrine, or, more specifically, p-synephrine, is an alkaloid, occurring naturally in some plants and animals, and also in approved drugs products as its m-substituted analog known as neo-synephrine. p-Synephrine (or formerly Sympatol and oxedrine [BAN]) and m-synephrine are known for their longer acting adrenergic effects compared to norepinephrine. This substance is present at very low concentrations in common foodstuffs such as orange juice and other orange (Citrus species) products, both of the “sweet” and “bitter” variety. The preparations used in traditional Chinese medicine (TCM), also known as Zhi Shi, are the immature and dried whole oranges from Citrus aurantium (Fructus Aurantii Immaturus). Extracts of the same material or purified synephrine are also marketed in the US, sometimes in combination with caffeine, as a weight-loss-promoting dietary supplement for oral consumption. While the traditional preparations have been in use for millennia as a component of TCM-formulas, synephrine itself is not an approved OTC drug. As a pharmaceutical, m-synephrine (phenylephrine) is still used as a sympathomimetic (i.e. for its hypertensive and vasoconstrictor properties), mostly by injection for the treatment of emergencies such as shock, and rarely orally for the treatment of bronchial problems associated with asthma and hay-fever.
Extracts of unripe fruit from Asian cultivars of Citrus aurantium (commonly known as “bitter” orange), collected in China, were reported to contain synephrine levels of about 0.1–0.3%, or ~1–3 mg/g.
Some dietary supplements, sold for the purposes of promoting weight-loss or providing energy, contain synephrine as one of several constituents.



The supplements containing Synephrine


If you know of any other quality supplement that has not been yet classified by us, please contact us and we will gladly consider adding it to our catalogue.


Synephrine - References & External links

Synephrine

TBS Ingredient ID (TBSI ID):
NameMolecular Formula:
Synephrine
Synonyms:
Oxedrine, P-Synephrine, Parasympatol
C9H13NO2
Classification TypeIdentifier
PubChem CID:
U.S. National Library of Medicine (PubChem)
InChI Key:
International Chemical Identifier hash (InChIKey) computed from chemical structure using the International Union of Pure and Applied Chemistry (IUPAC) standard
YRCWQPVGYLYSOX-UHFFFAOYSA-N
CAS:
A proprietary registry number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society (ACS)
94-07-5
NIST:
The National Institute of Standards and Technology (NIST)
ChemIDplus:
United States National Library of Medicine - TOXNET (Toxicology Data Network).
EC Number:
A seven-digit regulatory identifier currently assigned by the European Chemicals Agency (ECHA) known as a European Community (EC) number
202-300-9
ATC code:
WHO ATC Classification System. The Anatomical Therapeutic Chemical (ATC) Classification System is used for the classification of drugs. This pharmaceutical coding system divides drugs into different groups according to the organ or system on which they act and/or their therapeutic and chemical characteristics

The references to scientific articles about Synephrine are not meant to imply that any products treat, cure, or diagnose any disease or human condition. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.