Piperinox

Piperinox – Ingredients

• Guarana Seed Extract [22% Caffeine] (Paullinia Cupana)
  • Guarana Seed (Paullinia Cupana)
    A popular energy supplement, Guarana Extract offers one of the highest concentrations of caffeine among any plant. In fact, it can contain up to 3.6 to 5.8% caffeine by weight whereas coffee has only up to 2%. It has a stimulating effect. Supports lipid metabolism. Species: Paullinia Cupana,
    Family: Sapindaceae,
    European Medicines Agency: EMA: Paulliniae Semen,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH29CF20,
    References:
    Weight Loss: ALKHATIB, Ahmad; SEIJO, M.; LARUMBE, E.; NACLERIO, F. Acute effectiveness of a “fat-loss” product on substrate utilization, perception of hunger, mood state and rate of perceived exertion at rest and during exercise. Journal of the International Society of Sports Nutrition, 2015, 12.1: 44. PMID:26612980.
    
    
  • Caffeine (C₈H₁₀N₄O₂)
    Caffeine isn’t just a great ingredient to reduce fatigue and increase alertness and focus (as would your favorite cup of coffee). It also stimulates thermogenesis, slimming you down by turning up your body’s internal temperature. It can even reduce your appetite, helping you stay on track with your healthy eating choices. Caffeine instantly energizes, increases concentration and improves endurance. It allows you to practice longer and achieve better results.
    Caffeine: Caffeine, 1,3,7-Trimethylxanthine, Thein,
    PubChem CID: 2519,
    Chemical Abstracts Service: CAS: 58-08-2,
    ChemIDplus: 58-08-2,
    WHO Anatomical Therapeutic Chemical Classification System: ATC code: N06BC01,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS2C8E40,
    References:
    Weight Loss: TABRIZI, R.; SANEEI, P.; LANKARANI, K. B.; AKBARI, M.; KOLAHDOOZ, F.; ESMAILLZADEH, A.; NADI-RAVANDI, S.; MAZOOCHI, M.; ASEMI, Z. The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials. Critical reviews in food science and nutrition, 2018, 2018: 1-9. PMID:30335479, SMITH, Andrew Effects of caffeine on human behavior. Food and chemical toxicology, 2002, 40.9: 1243-1255. PMID:12204388.
    
• Cinnamon Bark Extract (Cinnamomum Cassia)
  • Chinese Cinnamon (Cinnamomum Cassia)
    Cinnamon Bark Extract: helps maintain a healthy blood sugar level, facilitates weight control, improves digestive comfort. Species: Cinnamomum Cassia,
    Family: Lauraceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IHAA97E0,
    References:
    Weight Loss: ABDALI, Daniyal; SAMSON, Sue E.; GROVER, Ashok Kumar How Effective Are Antioxidant Supplements in Obesity and Diabetes?. Medical Principles and Practice, 2015, 24.3: 201-215. PMID:25791371.
    
    
• Bitter Orange Fruit Extract [6% Synephrine] (Citrus Aurantium)
  • Bitter Orange (Citrus Aurantium)
    Bitter Orange Fruit Extract: facilitates weight control, supports the metabolism of fats and carbohydrates. Supports the work of the digestive system. Instantly suppresses the appetite, by stabilizing the level of glucose in the blood, and increases the metabolism of fat. Species: Citrus Aurantium,
    Family: Rutaceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2932E0,
    References:
    Weight Loss: PREUSS, Harry G.; DIFERDINANDO, D.; BAGCHI, D. Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview. Journal of medicine, 2002, 33.1-4: 247-264. PMID:12939122, COLKER, Carlon M.; DIFERDINANDO, D.; BAGCHI, D. Effects of Citrus aurantium extract, caffeine, and St. John’s wort on body fat loss, lipid levels, and mood states in overweight healthy adults. Current Therapeutic Research, 1999, 60.3: 145-153..
    
    
  • Synephrine (C₉H₁₃NO₂)
    Synephrine: Synephrine, Oxedrine, P-Synephrine, Parasympatol,
    PubChem CID: 7172,
    Chemical Abstracts Service: CAS: 94-07-5,
    ChemIDplus: 94-07-5,
    WHO Anatomical Therapeutic Chemical Classification System: ATC code: C01CA08,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS37FFF0,
    References:
    Weight Loss: STOHS, Sidney J.; PREUSS, H. G.; SHARA, M. A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. International journal of medical sciences, 2012, 9.7: 527. PMID:22991491, STOHS, Sidney J. Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p‐Synephrine. Phytotherapy research, 2017, 31.10: 1463-1474. PMID:28752649.
    
• Ginger Rhizomes Extract [5% Gingerols] (Zingiber Officinale)
  • Ginger Rhizomes (Zingiber Officinale)
    Ginger root extract reduces appetite, stimulates the production of gastric juice, facilitates recovery in many gastrointestinal diseases (accelerates metabolism, prevents further weight gain). Ginger Rhizomes Extract: supports the functioning of the immune system, has an antioxidant effect, supports the absorption of nutrients, it lowers the blood sugar level, supports carbohydrate metabolism. Species: Zingiber Officinale,
    Family: Zingiberaceae,
    European Medicines Agency: EMA: Zingiberis Rhizoma,
    Domain: Plantae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2959F0,
    References:
    Weight Loss: MAHARLOUEI, Najmeh; TABRIZI, R.; LANKARANI, K. B.; REZAIANZADEH, A.; AKBARI, M.; KOLAHDOOZ, F.; RAHIMI, M.; KENESHLOU, F.; ASEMI, Z. The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials. Critical reviews in food science and nutrition, 2018, 2018: 1-14. PMID:29393665, TAGHIZADEH, Mohsen; FARZIN, N.; TAHERI, S.; MAHLOUJI, M.; AKBARI, H.; KARAMALI, F.; ASEMI, Z. The effect of dietary supplements containing green tea, capsaicin and ginger extracts on weight loss and metabolic profiles in overweight women: A randomized double-blind placebo-controlled clinical trial. Annals of Nutrition and Metabolism, 2017, 70.4: 277-285. PMID:28595182.
    
    
  • Gingerol (C₁₇H₂₆O₄)
    Gingerol: Gingerol, 6-Gingerol,
    PubChem CID: 442793,
    Chemical Abstracts Service: CAS: 23513-14-6,
    ChemIDplus: 23513-14-6,
    FDA Substance Registration System – Unique Ingredient Identifier: UNII: 925QK2Z900,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS37D8E0.
    
• Cayenne Pepper Fruit Extract [10% Capsaicin] (Capsicum Annuum L.)
  • Cayenne Pepper (Capsicum Annuum)
    Cayenne powder isn’t just an ingredient for your favorite dishes. Spicy food increases your body temperature, forcing the body to expend energy (calories) to cool down. Consumed daily, Cayenne powder can increase metabolic rates by up to 25%. Cayenne Pepper Fruit Extract: has a positive impact on weight reduction, protects the stomach in case of contact with corrosive substances. Capsicum annuum extract supports the work of the digestive system, shielding the stomach. Activates fat reserves burning. Species: Capsicum Annuum,
    Family: Solanaceae,
    European Medicines Agency: EMA: Capsici Fructus,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH298100,
    References:
    Weight Loss: WHITING, Stephen; DERBYSHIRE, Emma; TIWARI, B. K. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite, 2012, 59.2: 341-348. PMID:22634197, VARGHESE, Sharon; et al. Chili pepper as a body weight-loss food. International journal of food sciences and nutrition, 2017, 68.4: 392-401. PMID:27899046.
    
    
  • Capsaicin (C₁₈H₂₇NO₃)
    Capsaicin: Capsaicin, Zostrix, Capsaicine, Transacin,
    PubChem CID: 1548943,
    Chemical Abstracts Service: CAS: 404-86-4,
    ChemIDplus: 404-86-4,
    WHO Anatomical Therapeutic Chemical Classification System: ATC code: M02AB01,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS39FBC0,
    References:
    Weight Loss: WHITING, Stephen; DERBYSHIRE, Emma; TIWARI, B. K. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite, 2012, 59.2: 341-348. PMID:22634197, TAGHIZADEH, Mohsen; FARZIN, N.; TAHERI, S.; MAHLOUJI, M.; AKBARI, H.; KARAMALI, F.; ASEMI, Z. The effect of dietary supplements containing green tea, capsaicin and ginger extracts on weight loss and metabolic profiles in overweight women: A randomized double-blind placebo-controlled clinical trial. Annals of Nutrition and Metabolism, 2017, 70.4: 277-285. PMID:28595182.
    
• Black Pepper Fruit Extract – BioPerine® [95% Piperine] (Piper Nigrum L.)
  • BioPerine®
    BioPerine® is an innovative form of piperine devoid of chemicals used for growing plants such as: fertilizers, concentrates, nutrients, pesticides or other plant protection products. The safety of its use has been confirmed by the European Food Safety Authority (EFSA). Thanks to better absorption, in comparison to the conventional form, and the use of this form, a significant increase in bioavailability of other valuable components of this supplement is observed. This even leads to a 30-fold increase in its effects. In addition, BioPerine® contains more piperine than black pepper extract, which further intensifies the effectiveness of the product.
    BioPerine®: BioPerine®,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS28E4C0.
    
  • Black Pepper (Piper Nigrum)
    Black pepper fruit extract – supports the secretion of digestive juices, increases the absorption of nutrients, regulates bowel movements. Species: Piper Nigrum,
    Family: Piperaceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2CB550,
    References:
    Weight Loss: TAKOOREE, Heerasing; AUMEERUDDY, M. Z.; RENGASAMY, K. R. R.; VENUGOPALA, K. N.; JEEWON, R.; ZENGIN, G.; MAHOMOODALLY, M. F. A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications. Critical reviews in food science and nutrition, 2019, 2019: 1-34. PMID:30740986, MUJUMDAR, Arvind Manohar; DHULEY, Jayant Nilkanth; DESHMUKH, Vinaykumar Keshav; RAMAN, Palghat Hariharan; NAIK, Suresh Ramnath Anti-inflammatory activity of piperine. Japanese Journal of Medical Science and Biology, 1990, 43.3: 95-100. PMID:2283727.
    
    
  • Piperine (C₁₇H₁₉NO₃)
    Piperine: Piperine, Bioperine, Piperin, 1-Piperoylpiperidine, Piperoylpiperidine, 1-Piperylpiperidine,
    PubChem CID: 638024,
    Chemical Abstracts Service: CAS: 94-62-2,
    ChemIDplus: 94-62-2,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS395F80,
    References:
    Weight Loss: NOGARA, Leonardo; et al. Piperine’s mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle. Proceedings of the National Academy of Sciences, 2016, 113.46: 13009-13014. PMID:27799519.
    
• Chromium (chromium picolinate) (C₁₈H₁₂CrN₃O₆)
  If you’re into strength training, you may know chromium picolinate as a supplement useful in building muscle, burning fat, and metabolizing carbohydrates. Beyond these benefits, chromium moves blood sugar, also known as glucose, from your bloodstream into your cells. Here, glucose can be used to transform the macronutrients you eat – fats, carbohydrates, and proteins – into energy. Allows you to reduce the problem of snacking. Thanks to the stabilization of blood sugar, it suppresses the appetite. Supports the metabolism of macronutrients.
  Chromium (chromium picolinate): Chromium Picolinate, Picolinic Acid Chromium(III) Salt, Chromium(III) Picolinate,
  PubChem CID: 151932,
  Chemical Abstracts Service: CAS: 14639-25-9,
  ChemIDplus: 14639-25-9,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS29A810-1,
  References:
  Weight Loss: PITTLER, M. H.; STEVINSON, C.; ERNST, E. Chromium picolinate for reducing body weight: meta-analysis of randomized trials. International journal of obesity, 2003, 27.4: 522. PMID:12664086, DOCHERTY, John P.; SACK, D. A.; ROFFMAN, M.; FINCH, M.; KOMOROWSKI, J. R. A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving. Journal of Psychiatric Practice®, 2005, 11.5: 302-314. PMID:16184071.
  

Recommended intake of this supplement: 1 capsule, daily (adults).