Joint / Bone Health - References & External links
The references to scientific articles about Joint / Bone Health are not meant to imply that any products treat, cure, or diagnose any disease or human condition. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.
- The properties of Ascorbic Acid for Joint / Bone Health:
Vitamin C, traditionally associated with scurvy, is an important nutrient for maintaining bone health. It is essential in the production of collagen in bone matrix. It also scavenges free radicals detrimental to bone health.- AGHAJANIAN, Patrick; et al. The Roles and Mechanisms of Actions of Vitamin C in Bone: New Developments. Journal of Bone and Mineral Research, 2015, 30.11: 1945-1955. PMID:26358868
- HART, Adam; et al. The Role of Vitamin C in Orthopedic Trauma and Bone Health. American journal of orthopedics (Belle Mead, N.J.), 2015, 44: 306-311. PMID:26161758
- CHIN, Kok-Yong; IMA-NIRWANA, Soelaiman. Vitamin C and Bone Health: Evidence From Cell, Animal and Human Studies. Current drug targets, 2018, 19.5: 439-450. PMID:26343111
Conclusion: Vitamin C may exert beneficial effects on bone, but more rigorous studies and clinical trials should be performed to validate this claim.
- The properties of Urtica Dioica for Joint / Bone Health:
- RANDALL, Colin; et al. Randomized Controlled Trial of Nettle Sting for Treatment of Base-Of-Thumb Pain. Journal of the Royal Society of Medicine, 2000, 93.6: 305-309. PMID:10911825
- The properties of Borago Officinalis for Joint / Bone Health:
- WAUQUIER, Fabien; et al. Borage and Fish Oils Lifelong Supplementation Decreases Inflammation and Improves Bone Health in a Murine Model of Senile Osteoporosis. Bone, 2012, 50.2: 553-561. PMID:21664309
- KAST, Richard E. Borage Oil Reduction of Rheumatoid Arthritis Activity May Be Mediated by Increased cAMP That Suppresses Tumor Necrosis Factor-Alpha. International immunopharmacology, 2001, 1.12: 2197-2199. PMID:11710548
- The properties of Zingiber Officinale for Joint / Bone Health:
- DROZDOV, Vladimir N.; et al. Influence of a Specific Ginger Combination on Gastropathy Conditions in Patients With Osteoarthritis of the Knee or Hip. The Journal of Alternative and Complementary Medicine, 2012, 18.6: 583-588. PMID:22784345
Conclusions: The ginger combination is as effective as diclofenac but safer in treating OA, being without effect on the stomach mucosa. The increased mucosal PGs synthesis in the ginger group supports an increased mucosa-protective potential. VAS; visual analogue scale, 0-100 mm. - ALTMAN, Roy D.; MARCUSSEN, K. C. Effects of a Ginger Extract on Knee Pain in Patients With Osteoarthritis. Arthritis & Rheumatism, 2001, 44.11: 2531-2538. PMID:11710709
Conclusion: A highly purified and standardized ginger extract had a statistically significant effect on reducing symptoms of OA of the knee. This effect was moderate. There was a good safety profile, with mostly mild GI adverse events in the ginger extract group. - SRIVASTAVA, K. C.; MUSTAFA, Thikra. Ginger (Zingiber Officinale) in Rheumatism and Musculoskeletal Disorders. Medical hypotheses, 1992, 39.4: 342-348. PMID:1494322
- DROZDOV, Vladimir N.; et al. Influence of a Specific Ginger Combination on Gastropathy Conditions in Patients With Osteoarthritis of the Knee or Hip. The Journal of Alternative and Complementary Medicine, 2012, 18.6: 583-588. PMID:22784345
- The properties of Alpinia Galanga for Joint / Bone Health:
- ALTMAN, Roy D.; MARCUSSEN, K. C. Effects of a Ginger Extract on Knee Pain in Patients With Osteoarthritis. Arthritis & Rheumatism, 2001, 44.11: 2531-2538. PMID:11710709
Conclusion: A highly purified and standardized ginger extract had a statistically significant effect on reducing symptoms of OA of the knee. This effect was moderate. There was a good safety profile, with mostly mild GI adverse events in the ginger extract group.
- ALTMAN, Roy D.; MARCUSSEN, K. C. Effects of a Ginger Extract on Knee Pain in Patients With Osteoarthritis. Arthritis & Rheumatism, 2001, 44.11: 2531-2538. PMID:11710709
- The properties of Cholecalciferol for Joint / Bone Health:
- SALE, Craig; ELLIOTT-SALE, Kirsty Jayne. Nutrition and Athlete Bone Health. Sports Medicine, 2019, 49.2: 139-151. PMID:31696454
- GOOLSBY, Marci A.; BONIQUIT, Nicole. Bone Health in Athletes: The Role of Exercise, Nutrition, and Hormones. Sports Health, 2017, 9.2: 108-117. PMID:27821574
Conclusion: To optimize bone health, adequate nutrition, appropriate weightbearing exercise, strength training, and adequate calcium and vitamin D are necessary throughout life.
- The properties of Magnesium for Joint / Bone Health:
- DIMAI, H. P.; PORTA, S.; WIRNSBERGER, G.; LINDSCHINGER, M.; PAMPERL, I.; DOBNIG, H.; WILDERS-TRUSCHNIG, M.; LAU, K. H. Daily oral magnesium supplementation suppresses bone turnover in young adult males. The Journal of Clinical Endocrinology & Metabolism, 1998, 83.8: 2742-2748. PMID:9709941
- The properties of Calcium for Joint / Bone Health:
- SALE, Craig; ELLIOTT-SALE, Kirsty Jayne. Nutrition and Athlete Bone Health. Sports Medicine, 2019, 49.2: 139-151. PMID:31696454
- GOOLSBY, Marci A.; BONIQUIT, Nicole. Bone Health in Athletes: The Role of Exercise, Nutrition, and Hormones. Sports Health, 2017, 9.2: 108-117. PMID:27821574
Conclusion: To optimize bone health, adequate nutrition, appropriate weightbearing exercise, strength training, and adequate calcium and vitamin D are necessary throughout life.
- The properties of Vitamin K1 for Joint / Bone Health:
- SCHWALFENBERG, Gerry Kurt. Vitamins K1 and K2: the emerging group of vitamins required for human health. Journal of nutrition and metabolism, 2017, 2017: . PMID:28698808
CONCLUSION: Vitamin K supplementation may be useful for a number of chronic conditions that are afflicting North Americans as the population ages. Supplementation may be required for bone and cardiovascular health.
- SCHWALFENBERG, Gerry Kurt. Vitamins K1 and K2: the emerging group of vitamins required for human health. Journal of nutrition and metabolism, 2017, 2017: . PMID:28698808
- The properties of Rosa Canina for Joint / Bone Health:
- REIN, E.; KHARAZMI, A.; WINTHER, K. A Herbal Remedy, Hyben Vital (Stand. Powder of a Subspecies of Rosa Canina Fruits), Reduces Pain and Improves General Wellbeing in Patients With Osteoarthritis--A Double-Blind, Placebo-Controlled, Randomised Trial. Phytomedicine, 2004, 11.5: 383-391. PMID:15330493
- The properties of Potassium for Joint / Bone Health:
- GRANCHI, Donatella; et al. Potassium citrate prevents increased osteoclastogenesis resulting from acidic conditions: Implication for the treatment of postmenopausal bone loss. PloS one, 2017, 12.7: e0181230. PMID:28715463
- GRANCHI, Donatella; et al. Potassium citrate supplementation decreases the biochemical markers of bone loss in a group of osteopenic women: the results of a randomized, double-blind, placebo-controlled pilot study. Nutrients, 2018, 10.9: 1293. PMID:30213095
- The properties of Potassium Citrate for Joint / Bone Health:
- GRANCHI, Donatella; et al. Potassium citrate prevents increased osteoclastogenesis resulting from acidic conditions: Implication for the treatment of postmenopausal bone loss. PloS one, 2017, 12.7: e0181230. PMID:28715463
- GRANCHI, Donatella; et al. Potassium citrate supplementation decreases the biochemical markers of bone loss in a group of osteopenic women: the results of a randomized, double-blind, placebo-controlled pilot study. Nutrients, 2018, 10.9: 1293. PMID:30213095
- The properties of Hydrolyzed Collagen for Joint / Bone Health:
- DANEAULT, Audrey; et al. Biological effect of hydrolyzed collagen on bone metabolism. Critical reviews in food science and nutrition, 2017, 57.9: 1922-1937. PMID:25976422
- MOSKOWITZ, Roland W. Role of collagen hydrolysate in bone and joint disease. In: Seminars in arthritis and rheumatism. WB Saunders, 2000, 2000: 87-99. PMID:11071580
CONCLUSIONS: Collagen hydrolysate is of interest as a therapeutic agent of potential utility in the treatment of osteoarthritis and osteoporosis. Its high level of safety makes it attractive as an agent for long-term use in these chronic disorders.
- The properties of Histidine for Joint / Bone Health:
- GERBER, Donald A.; et al. Low Free Serum Histidine Concentration in Rheumatoid Arthritis. A Measure of Disease Activity. The Journal of clinical investigation, 1975, 55.6: 1164-1173. PMID:1079527
- The properties of Boswellia Serrata for Joint / Bone Health:
- KAPIL, Aruna; MOZA, Nalini. Anticomplementary Activity of Boswellic Acids--An Inhibitor of C3-convertase of the Classical Complement Pathway. International journal of immunopharmacology, 1992, 14.7: 1139-1143. PMID:1452399
- SINGH, S.; et al. Boswellic Acids: A Leukotriene Inhibitor Also Effective Through Topical Application in Inflammatory Disorders. Phytomedicine, 2008, 15.6-7: 400-407. PMID:18222672
- The properties of Boswellic Acid for Joint / Bone Health:
- SINGH, S.; et al. Boswellic Acids: A Leukotriene Inhibitor Also Effective Through Topical Application in Inflammatory Disorders. Phytomedicine, 2008, 15.6-7: 400-407. PMID:18222672
- The properties of Aloe Vera for Joint / Bone Health:
- BOONYAGUL, Sani; et al. Effect of Acemannan, an Extracted Polysaccharide From Aloe Vera, on BMSCs Proliferation, Differentiation, Extracellular Matrix Synthesis, Mineralization, and Bone Formation in a Tooth Extraction Model. Odontology, 2014, 102.2: 310-317. PMID:23315202
- GODOY, Dyna Jeanne D.; et al. Acemannan Increased Bone Surface, Bone Volume, and Bone Density in a Calvarial Defect Model in Skeletally-Mature Rats. Journal of Dental Sciences, 2018, 13.4: 334-341. PMID:30895142
Conclusion: Acemannan is an effective bioactive agent for bone regeneration, enhancing bone growth as assayed in two- and three-dimensions.
- The properties of Acemannan for Joint / Bone Health:
- BOONYAGUL, Sani; et al. Effect of Acemannan, an Extracted Polysaccharide From Aloe Vera, on BMSCs Proliferation, Differentiation, Extracellular Matrix Synthesis, Mineralization, and Bone Formation in a Tooth Extraction Model. Odontology, 2014, 102.2: 310-317. PMID:23315202
- SONGSIRIPRADUBBOON, Siriporn; et al. Stimulation of Dentin Regeneration by Using Acemannan in Teeth With Lipopolysaccharide-induced Pulp Inflammation. Journal of endodontics, 2017, 43.7: 1097-1103. PMID:28477996
Conclusions: Acemannan is biocompatible with the dental pulp. Furthermore, acemannan stimulated dentin regeneration in teeth with reversible pulpitis. - GODOY, Dyna Jeanne D.; et al. Acemannan Increased Bone Surface, Bone Volume, and Bone Density in a Calvarial Defect Model in Skeletally-Mature Rats. Journal of Dental Sciences, 2018, 13.4: 334-341. PMID:30895142
Conclusion: Acemannan is an effective bioactive agent for bone regeneration, enhancing bone growth as assayed in two- and three-dimensions.
- The properties of Lonicera Japonica for Joint / Bone Health:
- KANG, Moonkyu; et al. The Analgesic and Anti-Inflammatory Effect of WIN-34B, a New Herbal Formula for Osteoarthritis Composed of Lonicera Japonica Thunb and Anemarrhena Asphodeloides BUNGE in Vivo. Journal of ethnopharmacology, 2010, 131.2: 485-496. PMID:20643199
Conclusion: When compared to celecoxib, WIN-34B exhibited similar or better anti-nociceptive and anti-inflammatory activities in osteoarthritic animal models, which may become a potential novel treatment for osteoarthritis.
- KANG, Moonkyu; et al. The Analgesic and Anti-Inflammatory Effect of WIN-34B, a New Herbal Formula for Osteoarthritis Composed of Lonicera Japonica Thunb and Anemarrhena Asphodeloides BUNGE in Vivo. Journal of ethnopharmacology, 2010, 131.2: 485-496. PMID:20643199
- The properties of Anemarrhena for Joint / Bone Health:
- KANG, Moonkyu; et al. The Analgesic and Anti-Inflammatory Effect of WIN-34B, a New Herbal Formula for Osteoarthritis Composed of Lonicera Japonica Thunb and Anemarrhena Asphodeloides BUNGE in Vivo. Journal of ethnopharmacology, 2010, 131.2: 485-496. PMID:20643199
Conclusion: When compared to celecoxib, WIN-34B exhibited similar or better anti-nociceptive and anti-inflammatory activities in osteoarthritic animal models, which may become a potential novel treatment for osteoarthritis.
- KANG, Moonkyu; et al. The Analgesic and Anti-Inflammatory Effect of WIN-34B, a New Herbal Formula for Osteoarthritis Composed of Lonicera Japonica Thunb and Anemarrhena Asphodeloides BUNGE in Vivo. Journal of ethnopharmacology, 2010, 131.2: 485-496. PMID:20643199
- The properties of Curcuma Longa for Joint / Bone Health:
- DEODHAR, S. D.; SETHI, R.; SRIMAL, R. C. Preliminary Study on Antirheumatic Activity of Curcumin (Diferuloyl Methane). Indian journal of medical research, 2013, 138.1: . PMID:7390600
- The properties of Curcumin for Joint / Bone Health:
- DEODHAR, S. D.; SETHI, R.; SRIMAL, R. C. Preliminary Study on Antirheumatic Activity of Curcumin (Diferuloyl Methane). Indian journal of medical research, 2013, 138.1: . PMID:7390600