Chin Kok-Yong, Ima-Nirwana Soelaiman
Current drug targets, 2018
Abstract
Background
Vitamin C, traditionally associated with scurvy, is an important nutrient for maintaining bone health. It is essential in the production of collagen in bone matrix. It also scavenges free radicals detrimental to bone health.
Objective
This review aims to assess the current evidence of the bone-sparing effects of vitamin C derived from cell, animal and human studies.
Results
Cell studies showed that vitamin C was able to induce osteoblast and osteoclast formation. However, high-dose vitamin C might increase oxidative stress and subsequently lead to cell death. Vitamin C-deficient animals showed impaired bone health due to increased osteoclast formation and decreased bone formation. Vitamin C supplementation was able to prevent bone loss in several animal models of bone loss. Human studies generally showed a positive relationship between vitamin C and bone health, indicated by bone mineral density, fracture probability and bone turnover markers. Some studies suggested that the relationship between vitamin C and bone health could be U-shaped, more prominent in certain subgroups and different between dietary and supplemental form. However, most of the studies were observational, thus could not confirm causality. One clinical trial was performed, but it was not a randomized controlled trial, thus confounding factors could not be excluded.
Conclusion
Vitamin C may exert beneficial effects on bone, but more rigorous studies and clinical trials should be performed to validate this claim.
Keywords
Ascorbic acid; bone; osteoblast; osteoclast; osteoporosis; vitamin C.
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
| PMID: | 26343111 |
|---|---|
| DOI: | 10.2174/1389450116666150907100838 |
| Category: | Joint / Bone Health |
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