Aghajanian Patrick, et al.
Journal of Bone and Mineral Research, 2015
Abstract
Vitamin C is an important antioxidant and cofactor that is involved in the regulation of development, function, and maintenance of several cell types in the body. Deficiencies in vitamin C can lead to conditions such as scurvy, which, among other ailments, causes gingivia, bone pain, and impaired wound healing. This review examines the functional importance of vitamin C as it relates to the development and maintenance of bone tissues. Analysis of several epidemiological studies and genetic mouse models regarding the effect of vitamin C shows a positive effect on bone health. Overall, vitamin C exerts a positive effect on trabecular bone formation by influencing expression of bone matrix genes in osteoblasts. Recent studies on the molecular pathway for vitamin C actions that include direct effects of vitamin C on transcriptional regulation of target genes by influencing the activity of transcription factors and by epigenetic modification of key genes involved in skeletal development and maintenance are discussed. With an understanding of mechanisms involved in the uptake and metabolism of vitamin C and knowledge of precise molecular pathways for vitamin C actions in bone cells, it is possible that novel therapeutic strategies can be developed or existing therapies can be modified for the treatment of osteoporotic fractures.
Keywords
BONE FRACTURE; ENDOCHONDRAL BONE FORMATION; EPIGENETICS; HYPOXIA-INDUCIBLE FACTORS; OSTEOBLASTS; OSTEOPOROSIS; PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2.
© 2015 American Society for Bone and Mineral Research.
Conflict of interest statement
DisclosureAll authors state that they have no conflicts of interest.
| PMID: | 26358868 |
|---|---|
| PMCID (Free PMC Article): | PMC4833003 |
| DOI: | 10.1002/jbmr.2709 |
| Category: | Joint / Bone Health |
The best supplements with Ascorbic Acid in Joint / Bone Health category:
- Fortuflex - Fortuflex2 is a remedy that helps to restore cartilage and bone tissue, release muscle and joint pain, and eliminate oedema and inflammation. It contains among others: Ascorbic Acid.
- Liposomal Vitamin C with Quali-C, 1,000 mg, 180 Vegetarian Capsules (Zenwise Health) - Zenwise Health® Liposomal Vitamin C is an antioxidant supplement that utilizes liposomal technology to ensure bioavailability of Vitamin C (Ascorbic Acid), an essential compound for the body. It contains among others: Ascorbic Acid.
- Collagen Active, Black Berry Cherry, 13.8 oz (378 g) (Zhou Nutrition) - You deserve supplements that work as hard as you do, which is why Zhou created a synergistic Collagen Active formula that’s designed for people who are on the move. It contains among others: Ascorbic Acid.
- Collagen Extreme with BioCell Collagen, 120 Capsules (Paradise Herbs) - Collagen is a vital protein of our body. It contains among others: Ascorbic Acid.
- AllFlex, All-In-One Joint Formula, 60 Capsules (ALLMAX Nutrition) - Athletes' Joints Take A Pounding. It contains among others: Ascorbic Acid.
- Bone Strength, 240 Capsules (Now Foods) - Microcrystalline Hydroxyapatite (MCHA) is a compound that normally makes up the crystalline matrix of bone and teeth and is the substance that gives them their rigidity. It contains among others: Ascorbic Acid.
- Vitamin D-3 & K-2, 1,000 IU / 45 mcg, 120 Veg Capsules (Now Foods) - NOW combines two nutrients extensively researched for their contribution to the health of bones, teeth and the cardiovascular system. It contains among others: Ascorbic Acid.
- Calcium & Magnesium, 250 Tablets (Now Foods) - NOW Calcium & Magnesium combines two essential minerals that work together to maintain several critical physiological processes. It contains among others: Ascorbic Acid.
Articles similar to "The Roles and Mechanisms of Actions of Vitamin C in Bone: New Developments."
- The role of Ascorbic Acid in Joint / Bone Health: The Role of Vitamin C in Orthopedic Trauma and Bone Health. (Vitamin C is an essential micronutrient with an adult daily recommended intake of 75 mg for women and 90 mg for men...)
- The impact of Ascorbic Acid on Joint / Bone Health: Vitamin C and Bone Health: Evidence From Cell, Animal and Human Studies. ( Vitamin C, traditionally associated with scurvy, is an important nutrient for maintaining bone health... Vitamin C may exert beneficial effects on bone, but more rigorous studies and clinical trials should be performed to validate this claim. )