Joint / Bone Health (Arthritis / Joint Pain)

Arthritis / Joint Pain - References & External links

The references to scientific articles about Arthritis / Joint Pain are not meant to imply that any products treat, cure, or diagnose any disease or human condition. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• The properties of Humulus Lupulus preventing Arthritis / Joint Pain:
  • LUKACZER, Daniel; et al. A Pilot Trial Evaluating Meta050, a Proprietary Combination of Reduced Iso-Alpha Acids, Rosemary Extract and Oleanolic Acid in Patients With Arthritis and Fibromyalgia. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 2005, 19.10: 864-869. PMID:16261517
• The properties of Urtica Dioica preventing Arthritis / Joint Pain:
  • RIEHEMANN, Kristina; BEHNKE, Bert; SCHULZE-OSTHOFF, Klaus. Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF‐κB. FEBS letters, 1999, 442.1: 89-94. PMID:9923611
  • CHRUBASIK, S.; et al. Evidence for Antirheumatic Effectiveness of Herba Urticae Dioicae in Acute Arthritis: A Pilot Study. Phytomedicine, 1997, 4.2: 105-108. PMID:23195396
  • SHAKIBAEI, Mehdi; et al. Botanical Extracts From Rosehip (Rosa Canina), Willow Bark (Salix Alba), and Nettle Leaf (Urtica Dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes. Evidence-Based Complementary and Alternative Medicine, 2012, 2012: 509383. PMID:22474508
• The properties of Salix Alba preventing Arthritis / Joint Pain:
  • SHAKIBAEI, Mehdi; et al. Botanical Extracts From Rosehip (Rosa Canina), Willow Bark (Salix Alba), and Nettle Leaf (Urtica Dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes. Evidence-Based Complementary and Alternative Medicine, 2012, 2012: 509383. PMID:22474508
• The properties of Borago Officinalis preventing Arthritis / Joint Pain:
  • SOEKEN, K. L.; MILLER, S. A.; ERNST, E. Herbal Medicines for the Treatment of Rheumatoid Arthritis: A Systematic Review. Rheumatology, 2003, 42.5: 652-659. PMID:12709541
    Conclusions: Given the number of herbal medicines promoted for RA, further research is needed to examine their efficacy, safety and potential drug interactions.
• The properties of Rosa Canina preventing Arthritis / Joint Pain:
  • WILLICH, S. N.; et al. Rose Hip Herbal Remedy in Patients With Rheumatoid Arthritis - A Randomised Controlled Trial. Phytomedicine, 2010, 17.2: 87-93. PMID:19818588
    Conclusion: The results indicate that patients with RA may benefit from additional treatment with rose hip powder.
  • KIRKESKOV, Bente; et al. The Effects of Rose Hip (Rosa Canina) on Plasma Antioxidative Activity and C-reactive Protein in Patients With Rheumatoid Arthritis and Normal Controls: A Prospective Cohort Study. Phytomedicine, 2011, 18.11: 953-958. PMID:21420288
    Conclusions: 10.5 g Litozin® in 28 days had neither effect on clinical symptoms or laboratory measurements in patients with RA or healthy controls. This is in contrast to previous intervention studies with rose hip powder that found a reduction in the concentration of CRP. The results of the present study indicate that a daily amount of approximately 10 g rose hip powder for one month has no anti-inflammatory and/or antioxidant effect.
  • SHAKIBAEI, Mehdi; et al. Botanical Extracts From Rosehip (Rosa Canina), Willow Bark (Salix Alba), and Nettle Leaf (Urtica Dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes. Evidence-Based Complementary and Alternative Medicine, 2012, 2012: 509383. PMID:22474508
• The properties of Rosmarinus Officinalis preventing Arthritis / Joint Pain:
  • LUKACZER, Daniel; et al. A Pilot Trial Evaluating Meta050, a Proprietary Combination of Reduced Iso-Alpha Acids, Rosemary Extract and Oleanolic Acid in Patients With Arthritis and Fibromyalgia. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 2005, 19.10: 864-869. PMID:16261517
  • SAHU, Arvind; RAWAL, Nenoo; PANGBURN, Michael K. Inhibition of Complement by Covalent Attachment of Rosmarinic Acid to Activated C3b. Biochemical pharmacology, 1999, 57.12: 1439-1446. PMID:10353266
  • AMARAL, Guilherme Pires; et al. Protective Action of Ethanolic Extract of Rosmarinus Officinalis L. In Gastric Ulcer Prevention Induced by Ethanol in Rats. Food and Chemical Toxicology, 2013, 55: 48-55. PMID:23279841
• The properties of Boswellia Serrata preventing Arthritis / Joint Pain:
  • UMAR, Sadiq; et al. Boswellia Serrata Extract Attenuates Inflammatory Mediators and Oxidative Stress in Collagen Induced Arthritis. Phytomedicine, 2014, 21.6: 847-856. PMID:24667331
  • SOEKEN, K. L.; MILLER, S. A.; ERNST, E. Herbal Medicines for the Treatment of Rheumatoid Arthritis: A Systematic Review. Rheumatology, 2003, 42.5: 652-659. PMID:12709541
    Conclusions: Given the number of herbal medicines promoted for RA, further research is needed to examine their efficacy, safety and potential drug interactions.
  • KIMMATKAR, N.; et al. Efficacy and Tolerability of Boswellia Serrata Extract in Treatment of Osteoarthritis of Knee--A Randomized Double Blind Placebo Controlled Trial. Phytomedicine, 2003, 10.1: 3-7. PMID:12622457
  • ETZEL, R. Special Extract of BOSWELLIA Serrata (H 15) in the Treatment of Rheumatoid Arthritis. Phytomedicine, 1996, 3.1: 91-94. PMID:23194870
  • UMAR, Sadiq; et al. Boswellia Serrata Extract Attenuates Inflammatory Mediators and Oxidative Stress in Collagen Induced Arthritis. Phytomedicine, 2014, 21.6: 847-856. PMID:24667331
• The properties of Boswellic Acid preventing Arthritis / Joint Pain:
  • HAROYAN, Armine; et al. Efficacy and Safety of Curcumin and Its Combination With Boswellic Acid in Osteoarthritis: A Comparative, Randomized, Double-Blind, Placebo-Controlled Study. BMC complementary and alternative medicine, 2018, 18.1: 7. PMID:29316908
    Conclusions: Twelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with OA. Curcumin in combination with boswellic acid is more effective. Combining Curcuma longa and Boswellia serrata extracts in Curamin® increases the efficacy of OA treatment presumably due to synergistic effects of curcumin and boswellic acid. Trial registration: This trial is registered at the database www.clinicaltrials.gov. Study registration number: NCT02390349.
  • KHANNA, Dinesh; et al. Natural Products as a Gold Mine for Arthritis Treatment. Current opinion in pharmacology, 2007, 7.3: 344-351. PMID:17475558
• The properties of Oenothera Biennis preventing Arthritis / Joint Pain:
  • BELCH, J. J.; et al. Effects of Altering Dietary Essential Fatty Acids on Requirements for Non-Steroidal Anti-Inflammatory Drugs in Patients With Rheumatoid Arthritis: A Double Blind Placebo Controlled Study. Annals of the rheumatic diseases, 1988, 47.2: 96-104. PMID:2833184
  • BRZESKI, M.; MADHOK, R.; CAPELL, H. A. Evening Primrose Oil in Patients With Rheumatoid Arthritis and Side-Effects of Non-Steroidal Anti-Inflammatory Drugs. Rheumatology, 1991, 30.5: 370-372. PMID:1913008
• The properties of D-Glucosamine preventing Arthritis / Joint Pain:
  Glucosamine stimulates the formation of hyaluronic acid, which retains water in the connective tissue, providing elasticity; releases joint pain, improves its functioning, and has no side effects.
  • VASILIADIS, Haris S.; TSIKOPOULOS, Konstantinos. Glucosamine and chondroitin for the treatment of osteoarthritis. World journal of orthopedics, 2017, 8.1: 1. PMID:28144573
  • MCALINDON, Timothy E.; et al. Glucosamine and Chondroitin for Treatment of OsteoarthritisA Systematic Quality Assessment and Meta-analysis. Jama, 2000, 283.11: 1469-1475.
    Conclusions:Trials of glucosamine and chondroitin preparations for OA symptoms demonstrate moderate to large effects, but quality issues and likely publication bias suggest that these effects are exaggerated. Nevertheless, some degree of efficacy appears probable for these preparations.
  • ZHU, Xiaoyue; et al. Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials. Journal of orthopaedic surgery and research, 2018, 13.1: 1-9. PMID:29980200
    Conclusions: Given the effectiveness of these symptomatic slow-acting drugs, oral chondroitin is more effective than placebo on relieving pain and improving physical function. Glucosamine showed effect on stiffness outcome. Regarding on the limited number of combination therapy, further studies need to investigate the accurate effectiveness. This information accompanied with the tolerability and economic costs of included treatments would be conducive to making decisions for clinicians.
• The properties of Chondroitin preventing Arthritis / Joint Pain:
  Chondroitin stimulates metabolic processes in the joints, slows down and stops cartilage destruction, and starts its restoration.
  • SINGH, Jasvinder A.; et al. Chondroitin for osteoarthritis. Cochrane Database of Systematic Reviews, 2015, 2015: 1. PMID:25629804
    conclusions: A review of randomized trials of mostly low quality reveals that chondroitin (alone or in combination with glucosamine) was better than placebo in improving pain in participants with osteoarthritis in short-term studies. The benefit was small to moderate with an 8 point greater improvement in pain (range 0 to 100) and a 2 point greater improvement in Lequesne's index (range 0 to 24), both seeming clinically meaningful. These differences persisted in some sensitivity analyses and not others. Chondroitin had a lower risk of serious adverse events compared with control. More high-quality studies are needed to explore the role of chondroitin in the treatment of osteoarthritis. The combination of some efficacy and low risk associated with chondroitin may explain its popularity among patients as an over-the-counter supplement.
  • ZHU, Xiaoyue; et al. Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials. Journal of orthopaedic surgery and research, 2018, 13.1: 1-9. PMID:29980200
    Conclusions: Given the effectiveness of these symptomatic slow-acting drugs, oral chondroitin is more effective than placebo on relieving pain and improving physical function. Glucosamine showed effect on stiffness outcome. Regarding on the limited number of combination therapy, further studies need to investigate the accurate effectiveness. This information accompanied with the tolerability and economic costs of included treatments would be conducive to making decisions for clinicians.
  • VASILIADIS, Haris S.; TSIKOPOULOS, Konstantinos. Glucosamine and chondroitin for the treatment of osteoarthritis. World journal of orthopedics, 2017, 8.1: 1. PMID:28144573
  • MCALINDON, Timothy E.; et al. Glucosamine and Chondroitin for Treatment of OsteoarthritisA Systematic Quality Assessment and Meta-analysis. Jama, 2000, 283.11: 1469-1475.
    Conclusions:Trials of glucosamine and chondroitin preparations for OA symptoms demonstrate moderate to large effects, but quality issues and likely publication bias suggest that these effects are exaggerated. Nevertheless, some degree of efficacy appears probable for these preparations.