Khanna Dinesh, et al.
Current opinion in pharmacology, 2007
Abstract
Arthritis, an inflammation of the joints, is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines (e.g. tumour necrosis factor and interleukin-1beta) and pro-inflammatory enzymes that mediate the production of prostaglandins (e.g. cyclooxygenase-2) and leukotrienes (e.g. lipooxygenase), together with the expression of adhesion molecules and matrix metalloproteinases, and hyperproliferation of synovial fibroblasts. All of these factors are regulated by the activation of the transcription factor nuclear factor-kappaB. Thus, agents that suppress the expression of tumour necrosis factor-alpha, interleukin-1beta, cyclooxygenase-2, lipooxygenase, matrix metalloproteinases or adhesion molecules, or suppress the activation of NF-kappaB, all have potential for the treatment of arthritis. Numerous agents derived from plants can suppress these cell signaling intermediates, including curcumin (from turmeric), resveratrol (red grapes, cranberries and peanuts), tea polyphenols, genistein (soy), quercetin (onions), silymarin (artichoke), guggulsterone (guggul), boswellic acid (salai guggul) and withanolides (ashwagandha). Indeed, several preclinical and clinical studies suggest that these agents have potential for arthritis treatment. Although gold compounds are no longer employed for the treatment of arthritis, the large number of inexpensive natural products that can modulate inflammatory responses, but lack side effects, constitute 'goldmines' for the treatment of arthritis.
| PMID: | 17475558 |
|---|---|
| DOI: | 10.1016/j.coph.2007.03.002 |
| Category: | Arthritis / Joint Pain |
The best supplements with Boswellic Acid in Arthritis / Joint Pain category:
- Boswellia Extract, 500 mg, 90 Softgels (Now Foods) - NOW Boswellia Extract is a standardized extract of Boswellia serrata, also known as Frankincense, a resinous botanical that has been used for centuries by traditional Ayurvedic herbalists. It contains among others: Boswellic Acid.
- Boswellia Extract, 250 mg, 120 Veg Capsules (Now Foods) - NOW Boswellia Extract is a standardized extract of Boswellia serrata, also known as Frankincense, a resinous botanical that has been traditionally used by Ayurvedic herbalists for centuries. It contains among others: Boswellic Acid.
Articles similar to "Natural Products as a Gold Mine for Arthritis Treatment."
- The significance of Boswellic Acid for Arthritis / Joint Pain: Efficacy and Safety of Curcumin and Its Combination With Boswellic Acid in Osteoarthritis: A Comparative, Randomized, Double-Blind, Placebo-Controlled Study. ( The aim of this clinical trial was to assess the efficacy and safety of curcuminoid complex extract from turmeric rhizome with turmeric volatile oil (CuraMed®) and its combination with boswellic acid extract from Indian frankincense root (Curamin®) vs placebo for the treatment of 40- to 70-year-old patients with osteoarthritis (OA)... Twelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with OA. Curcumin in combination with boswellic acid is more effective. Combining Curcuma longa and Boswellia serrata extracts in Curamin® increases the efficacy of OA treatment presumably due to synergistic effects of curcumin and boswellic acid. Trial registration: This trial is registered at the database www.clinicaltrials.gov. Study registration number: NCT02390349. )
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