Haroyan Armine, et al.
BMC complementary and alternative medicine, 2018
Abstract
Background
The aim of this clinical trial was to assess the efficacy and safety of curcuminoid complex extract from turmeric rhizome with turmeric volatile oil (CuraMed®) and its combination with boswellic acid extract from Indian frankincense root (Curamin®) vs placebo for the treatment of 40- to 70-year-old patients with osteoarthritis (OA).
Methods
The effects of CuraMed® 500-mg capsules (333 mg curcuminoids) and Curamin® 500-mg capsules (350 mg curcuminoids and 150 mg boswellic acid) taken orally three times a day for 12 weeks in 201 patients was investigated in a three-arm, parallel-group, randomized, double-blinded, placebo-controlled trial. Primary outcome efficacy measures included OA physical function performance-based tests, the WOMAC recommended index of joint pain, morning stiffness, limitations of physical function, and the patients' global assessment of disease severity.
Results
Favorable effects of both preparations compared to placebo were observed after only 3 months of continuous treatment. A significant effect of Curamin® compared to placebo was observed both in physical performance tests and the WOMAC joint pain index, while superior efficacy of CuraMed vs placebo was observed only in physical performance tests. The effect size compared to placebo was comparable for both treatment groups but was superior in the Curamin® group. The treatments were well tolerated.
Conclusions
Twelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with OA. Curcumin in combination with boswellic acid is more effective. Combining Curcuma longa and Boswellia serrata extracts in Curamin® increases the efficacy of OA treatment presumably due to synergistic effects of curcumin and boswellic acid.
Trial registration
This trial is registered at the database www.clinicaltrials.gov. Study registration number: NCT02390349.
Conflict of interest statement
Ethics approval and consent to participateEthical approval was obtained from the local Ethics Committee (Health Research Ethics Board at the Yerevan Medical State University of Armenia; 96/13; 22.04.2013), which approved all procedures and written informed consent was obtained from all participants. The study was conducted in accordance with the Declaration of Helsinki and local laws and regulations. All participants gave written informed consent. Approved all procedures and written informed consent was obtained from all participants.
Consent for publication
Not applicable.
Competing interests
The authors declare that they have no competing interests. Verum and placebo capsules used in the study were donated by the manufacturer Europharma USA Inc. Europharma USA Inc. had no other involvement in the study. Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
| PMID: | 29316908 |
|---|---|
| DOI: | 10.1186/s12906-017-2062-z |
| PMCID (Free PMC Article): | PMC5761198 |
| Category: | Arthritis / Joint Pain |
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- Boswellia Extract, 250 mg, 120 Veg Capsules (Now Foods) - NOW Boswellia Extract is a standardized extract of Boswellia serrata, also known as Frankincense, a resinous botanical that has been traditionally used by Ayurvedic herbalists for centuries. It contains among others: Boswellic Acid.
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