Reddy G. Kesava, Dhar S. C.
The Italian journal of biochemistry, 1987
Abstract
The effect of new non-steroidal anti-inflammatory agents on lysosomal stability was studied by determining the activity of beta-glucuronidase, a typical lysosomal enzyme, in various sub-cellular fractions and its release from the lysosome-rich fraction. Adjuvant arthritic animals showed a significant increase in the beta-glucuronidase activity in sub-cellular fractions. The increased rate of the release of beta-glucuronidase from lysosome-rich fraction clearly suggested that arthritic syndrome caused decreased stability of the lysosomes. Administration of boswellic acids or salai-guggal to arthritic animals was found to increase the lysosomal stability by inhibiting the rate of release from lysosome-rich fraction and reducing beta-glucuronidase activity in various sub-cellular fractions. Of the two anti-inflammatory agents tested, salai-guggal was found to afford more therapeutic value than boswellic acids.
| PMID: | 3429205 |
|---|---|
| Category: | General properties of Boswellic Acid |
Articles similar to "Effect of a New Non-Steroidal Anti-Inflammatory Agent on Lysosomal Stability in Adjuvant Induced Arthritis."
- The properties of Boswellic Acid: Pharmacological Evidences for Cytotoxic and Antitumor Properties of Boswellic Acids From Boswellia Serrata. (Ethnopharmacological relevance: Increasing research on traditional herbal medicines and their phytoconstituents has recognized their usefulness in complementary as adjuvant to chemotherapy in various types of cancers... Boswellic acids appear to be promising candidates for anticancer drug development in future. However, further in vivo studies are needed. Studies in combination with clinically used anticancer drugs and QSAR studies on individual boswellic acid also need to be carried out. )