Umar Sadiq, et al.
Phytomedicine, 2014
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease which leads to destruction of joints. Current treatment modalities for RA either produce symptomatic relief (NSAIDs) or modify the disease process (DMARDs). Though effective, their use is also limited by their side effects. As a result, the interest in alternative, well tolerated anti-inflammatory remedies has re-emerged. Our aim was to evaluate the antioxidant and antiarthritic activity of Boswellia serrata gum resin extract (BSE) in collagen induced arthritis. Arthritis was induced in male Wistar rats by collagen induced arthritis (CIA) method. BSE was administered at doses of 100 and 200mg/kg body weight once daily for 21 days. The effects of treatment in the rats were assessed by biochemical (articular elastase, MPO, LPO, GSH, catalase, SOD and NO), inflammatory mediators (IL-1β, IL-6, TNF-α, IL-10, IFN-γ and PGE2), and histological studies in joints. BSE was effective in bringing significant changes on all the parameters (articular elastase, MPO, LPO, GSH, catalase, SOD and NO) studied. Oral administration of BSE resulted in significantly reduced levels of inflammatory mediators (IL-1β, IL-6, TNF-α, IFN-γ and PGE2), and increased level of IL-10. The protective effects of BSE against RA were also evident from the decrease in arthritis scoring and bone histology. The abilities to inhibit proinflammatory cytokines and modulation of antioxidant status suggest that the protective effect of Boswellia serrata extract on arthritis in rats might be mediated via the modulation of immune system.
Keywords
Boswellia serrata; Collagen induced arthritis; Cytokines; PGE(2).
Copyright © 2014 Elsevier GmbH. All rights reserved.
| PMID: | 24667331 |
|---|---|
| DOI: | 10.1016/j.phymed.2014.02.001 |
| Category: | Arthritis / Joint Pain |
The best supplements with Boswellia Serrata in Arthritis / Joint Pain category:
- Boswellia Extract, 500 mg, 90 Softgels (Now Foods) - NOW Boswellia Extract is a standardized extract of Boswellia serrata, also known as Frankincense, a resinous botanical that has been used for centuries by traditional Ayurvedic herbalists. It contains among others: Boswellia Serrata.
- Boswellia Extract, 250 mg, 120 Veg Capsules (Now Foods) - NOW Boswellia Extract is a standardized extract of Boswellia serrata, also known as Frankincense, a resinous botanical that has been traditionally used by Ayurvedic herbalists for centuries. It contains among others: Boswellia Serrata.
Articles similar to "Boswellia Serrata Extract Attenuates Inflammatory Mediators and Oxidative Stress in Collagen Induced Arthritis."
- The significance of Boswellia Serrata for Arthritis / Joint Pain: Boswellia Serrata Extract Attenuates Inflammatory Mediators and Oxidative Stress in Collagen Induced Arthritis. (Rheumatoid arthritis (RA) is a chronic inflammatory disease which leads to destruction of joints...)
- The role of Boswellia Serrata in Arthritis / Joint Pain: Herbal Medicines for the Treatment of Rheumatoid Arthritis: A Systematic Review. (Objective: With the growing interest in herbal therapies among persons with rheumatoid arthritis, there exists a need for investigation into their safety and efficacy... Given the number of herbal medicines promoted for RA, further research is needed to examine their efficacy, safety and potential drug interactions.)
- The impact of Boswellia Serrata on Arthritis / Joint Pain: Efficacy and Tolerability of Boswellia Serrata Extract in Treatment of Osteoarthritis of Knee--A Randomized Double Blind Placebo Controlled Trial. (Osteoarthritis is a common, chronic, progressive, skeletal, degenerative disorder, which commonly affects the knee joint... Given the number of herbal medicines promoted for RA, further research is needed to examine their efficacy, safety and potential drug interactions.)
- The significance of Boswellia Serrata for Arthritis / Joint Pain: Special Extract of BOSWELLIA Serrata (H 15) in the Treatment of Rheumatoid Arthritis. (H15, a special extract of the gum resin of Boswellia serrata (BS) is effective in the treatment of rheumatoid arthritis (RA)... Given the number of herbal medicines promoted for RA, further research is needed to examine their efficacy, safety and potential drug interactions.)