Gayathri B., et al.
International immunopharmacology, 2007
Abstract
The aim of the present study is to probe the anti-inflammatory potential of the plant Boswellia serrata by studying the effect of the crude extract and the pure compound isolated from it on key inflammatory mediators like TNFalpha, IL-1beta, and NO thus enabling the understanding of the key signaling events involved. The crude methanolic extract and the pure compound were analysed for their inhibitory effect on TNFalpha, IL-1beta and IL-6. The results demonstrated that all three cytokines are down regulated when PBMCs are cultured in the presence of crude extract or the pure compound at various time points. Observations on Th1/Th2 cytokines revealed marked down regulation of Th1 cytokines IFNgamma and IL-12 while the Th2 cytokines IL-4 and IL-10 were up regulated upon treatment with crude extract and pure compound. The extract and the pure compound isolated also showed considerable inhibition of NO production in activated RAW 264.7 cells, possibly via suppression of inducible NO synthase mRNA expression. Further to elucidate the underlying mechanism of action the effect of 12-ursene 2-diketone on LPS-induced activation of MAPK has also been examined. Our results demonstrated that 12-ursene 2-diketone inhibits the expression of pro-inflammatory cytokines and mediators via inhibition of phosphorylation of the MAP kinases JNK and p38 while no inhibition was seen in ERK phosphorylation in LPS-stimulated PBMCs. The above study therefore indicates that the crude methanolic extract and the isolated pure compound are capable of carrying out a natural anti-inflammatory activity at sites where chronic inflammation is present by switching off the pro-inflammatory cytokines and mediators, which initiate the process.
| PMID: | 17321470 |
|---|---|
| DOI: | 10.1016/j.intimp.2006.12.003 |
| Category: | Allergy / Immune |
The best supplements with Boswellia Serrata in Allergy / Immune category:
- Boswellia Extract, 500 mg, 90 Softgels (Now Foods) - NOW Boswellia Extract is a standardized extract of Boswellia serrata, also known as Frankincense, a resinous botanical that has been used for centuries by traditional Ayurvedic herbalists. It contains among others: Boswellia Serrata.
- Boswellia Extract, 250 mg, 120 Veg Capsules (Now Foods) - NOW Boswellia Extract is a standardized extract of Boswellia serrata, also known as Frankincense, a resinous botanical that has been traditionally used by Ayurvedic herbalists for centuries. It contains among others: Boswellia Serrata.
Articles similar to "Pure Compound From Boswellia Serrata Extract Exhibits Anti-Inflammatory Property in Human PBMCs and Mouse Macrophages Through Inhibition of TNFalpha, IL-1beta, NO and MAP Kinases."
- The significance of Boswellia Serrata for Allergy / Immune: Natural Anti-Inflammatory Products and Leukotriene Inhibitors as Complementary Therapy for Bronchial Asthma. (Objective: To assess the efficacy of a combination of Boswellia serrata, licorice root (Glycyrrhiza glabra) and Tumeric root (Curcuma longa) as natural leukotriene inhibitor, antiinflammatory and antioxidant products respectively in controlling bronchial asthma... The used extract contained Boswellia serrata, Curcuma longa and Glycyrrhiza has a pronounced effect in the management of bronchial asthma. )
- The impact of Boswellia Serrata on Allergy / Immune: Review of Anti-Inflammatory Herbal Medicines. (Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as a complementary medicine... The used extract contained Boswellia serrata, Curcuma longa and Glycyrrhiza has a pronounced effect in the management of bronchial asthma. )