Vasiliadis Haris S., Tsikopoulos Konstantinos
World journal of orthopedics, 2017
Abstract
The prevalence of primary or idiopathic osteoarthritis (OA) of knee and hip joints has substantially increased in general population during the last decades. Analgesics and non-steroidal anti-inflammatory drugs are currently extensively used as non-surgical treatment options. However, they act as symptomatic treatments, not offering a cure of OA and they are accused for an increased risk of adverse events. Glucosamine (GL) and chondroitin (CH) are nutritional supplements that have recently gained widespread use as treatment options for OA. They potentially or theoretically act as chondroprotectors or/and as "disease-modifying OA drugs" offering not only symptomatic relief but also alteration of the natural history of OA. However, although many studies have showed a significant treatment effect, accompanied with remarkable safety, there is still controversy regarding their relative effectiveness compared with placebo or other treatments. The scope of this review is to present and critically evaluate the current evidence-based information regarding the administration of GL and CH for the treatment of knee or hip OA. Our focus is to investigate the clinical efficacy and safety after the use of these supplements. An effect of GL and CH on both clinical and radiological findings has been shown. However, only a few high-quality level I trials exist in the literature, especially on the assessment of radiological progression of OA. The effect sizes are generally small and probably not clinically relevant. Even the validity of these results is limited by the high risk of bias introduced in the studies. Both GL and CH seem to be safe with no serious adverse events reported. There is currently no convincing information for the efficacy of GL and CH on OA.
Keywords
Cartilage; Chondroitin; Glucosamine; Knee; Osteoarthritis.
Conflict of interest statement
Conflict-of-interest statement: The authors declare no conflict of interest.| PMID: | 28144573 |
|---|---|
| PMCID (Free PMC Article): | PMC5241539 |
| DOI: | 10.5312/wjo.v8.i1.1 |
| Category: | Arthritis / Joint Pain |
The best supplements with D-Glucosamine or Chondroitin in Arthritis / Joint Pain category:
- Fortuflex - Fortuflex2 is a remedy that helps to restore cartilage and bone tissue, release muscle and joint pain, and eliminate oedema and inflammation. It contains among others: D-Glucosamine, Chondroitin.
- Glucosamine & Chondroitin with MSM, 180 Capsules (Now Foods) - NOW Glucosamine & Chondroitin known nutrients available for the support of healthy joints in one dietary supplement. It contains among others: D-Glucosamine, Chondroitin.
Articles similar to "Glucosamine and chondroitin for the treatment of osteoarthritis."
- The significance of Chondroitin for Arthritis / Joint Pain: Glucosamine and Chondroitin for Treatment of OsteoarthritisA Systematic Quality Assessment and Meta-analysis. (Context: Glucosamine and chondroitin preparations are widely touted in the lay press as remedies for osteoarthritis (OA), but uncertainty about their efficacy exists among the medical community...Trials of glucosamine and chondroitin preparations for OA symptoms demonstrate moderate to large effects, but quality issues and likely publication bias suggest that these effects are exaggerated. Nevertheless, some degree of efficacy appears probable for these preparations.)
- The role of Chondroitin in Arthritis / Joint Pain: Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials. (Objective: To assess the symptomatic effectiveness and safety of oral symptomatic slow-acting drugs (SYSADOAs) on the treatment of knee and/or hip osteoarthritis, such as chondroitin, glucosamine, and combination treatment with chondroitin plus glucosamine... Given the effectiveness of these symptomatic slow-acting drugs, oral chondroitin is more effective than placebo on relieving pain and improving physical function. Glucosamine showed effect on stiffness outcome. Regarding on the limited number of combination therapy, further studies need to investigate the accurate effectiveness. This information accompanied with the tolerability and economic costs of included treatments would be conducive to making decisions for clinicians. )
- The significance of Chondroitin for Arthritis / Joint Pain: Chondroitin for osteoarthritis. ( Osteoarthritis, a common joint disorder, is one of the leading causes of disability... A review of randomized trials of mostly low quality reveals that chondroitin (alone or in combination with glucosamine) was better than placebo in improving pain in participants with osteoarthritis in short-term studies. The benefit was small to moderate with an 8 point greater improvement in pain (range 0 to 100) and a 2 point greater improvement in Lequesne's index (range 0 to 24), both seeming clinically meaningful. These differences persisted in some sensitivity analyses and not others. Chondroitin had a lower risk of serious adverse events compared with control. More high-quality studies are needed to explore the role of chondroitin in the treatment of osteoarthritis. The combination of some efficacy and low risk associated with chondroitin may explain its popularity among patients as an over-the-counter supplement. )
Previous article
A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.).