NooCube

NooCube – Składniki

• Alpha Glycerylphosphorylcholine (C₈H₂₀NO₆P)
  Alpha Glycerylphosphorylcholine (Alpha GPC) is thought to increase levels of acetylcholine in the brain. Acetylcholine is a neurotransmitter – chemical messengers that communicate between brain cells. It is important for memory, learning and concentration, which is why it is known as the learning neurotransmitter. Alpha GPC has demonstrated such a strong ability to improve cognitive function, it is considered a possible treatment for Alzheimer’s disease.
  Alpha Glycerylphosphorylcholine: Choline Glycerophosphate, Alpha-Glycerylphosphorylcholine, Colina Glicerofosfato, Cholini Glycerophosphas, Cholini Alfosceras, Alpha-GPC,
  PubChem CID: 71920,
  Chemical Abstracts Service: CAS: 28319-77-9,
  ChemIDplus: 28319-77-9,
  WHO Anatomical Therapeutic Chemical Classification System: ATC code: N07AX02,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS360420,
  References:
  Brain / Mental Clarity: MORENO, Maria De Jesus Cognitive improvement in mild to moderate Alzheimer’s dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial. Clinical therapeutics, 2003, 25.1: 178-193. PMID:12637119, DI PERRI, R.; COPPOLA, G.; AMBROSIO, L. A.; GRASSO, A.; PUCA, F. M.; RIZZO, M. A multicentre trial to evaluate the efficacy and tolerability of α-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. Journal of international medical research, 1991, 19.4: 330-341. PMID:1916007.
  
• Toothed Clubmoss (0.5% Huperzine-A)
  • Toothed Clubmoss (Huperzia Serrata)Species: Huperzia Serrata,
    Family: Lycopodiaceae,
    Domain: Plantae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH3A22D0,
    References:
    Brain / Mental Clarity: HUANG, Ji; ZHAO, Ailing Analysis of dynamic change of huperzine A content in Huperzia serrata. China journal of Chinese materia medica, 2010, 35.19: 2511-2515. PMID:21174755.
    
    
  • Huperzine A (C₁₅H₁₈N₂O)
    An extract from the Chinese club moss plant, Huperzine-A is an acetylcholinesterase (AChE) inhibitor. AChE breaks down the learning neurotransmitter acetylcholine. By preventing acetylcholine levels from decreasing, Huperzine A creates a surplus of acetylcholine, which can lead to improved mental clarity, concentration and memory.
    Huperzine A: Selagine, HupA,
    PubChem CID: 854026,
    Chemical Abstracts Service: CAS: 102518-79-6,
    ChemIDplus: 102518-79-6,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS345670,
    References:
    Brain / Mental Clarity: SUN, Q. Q.; XU, S. S.; PAN, J. L.; GUO, H. M.; CAO, W. Q. Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Acta pharmacologica Sinica, 1999, 20.7: 601-603. PMID:10678121, XU, W. A.; GAO, Z. X.; WENG, Z.; DU, Z. M.; YANG, J. S.; ZHANG, M. L.; TONG, Z. H.; FANG, Y. S.; CHAI, X. S. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer’s disease. Acta pharmacologica Sinica, 1995, 16.5: 391-395. PMID:8701750.
    
• Cat’s Claw 4:1 Concentrated Extract
  • Vilcacora, Koci pazur (Uncaria Tomentosa)
    Derived naturally from Uncaria tomentosa, a vine that grows in the Amazon rainforest, Cat’s Claw is believed to have neuroprotective benefits. It contains antioxidants that can help enhance the body’s natural ability to repair environmental-stress related DNA damage to cells. Cat’s Claw can help improve your brain health and cognitive performance. Species: Uncaria Tomentosa,
    Family: Rubiaceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH362B30,
    References:
    Brain / Mental Clarity: SNOW, Alan D.; et al. The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles Scientific reports, 2019, 9.1: 561. PMID:30728442.
    
    
• Bacopin® (Bacopa Monnieri 12:1 Extract)
  • Bacopa (Bacopa Monnieri)
    Pomaga przyswajać wiedzę, wzmacnia zdolność koncentracji, usprawnia pracę mózgu, polepsza funkcje poznawcze. Species: Bacopa Monnieri,
    Family: Plantaginaceae,
    Domain: Plantae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH358EF0,
    References:
    Brain / Mental Clarity: MCPHEE, G. M.; DOWNEY, L. A.; NOBLE, A.; STOUGH, C. Cognitive training and Bacopa monnieri: Evidence for a combined intervention to alleviate age associated cognitive decline. Medical hypotheses, 2016, 95: 71-76. PMID:27692172, MORGAN, A.; STEVENS, J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. The journal of alternative and complementary medicine, 2010, 16.7: 753-759. PMID:20590480.
    
    
• Oat Straw Extract 10:1
  • Owies zwyczajny (Avena Sativa)
    Also known as Avena sativa, Oat Straw comes from wild green oats and has been used as a brain booster in folk medicine since the Middle Ages. Oat straw is believed to work by increasing alpha-2 waves in the brain – which are highly active during periods of wakefulness – as well as controlling inflammation within artery walls. This increases blood flow to the brain, helping you feel more awake and alert. Species: Avena Sativa,
    Family: Poaceae,
    European Medicines Agency: EMA: Avenae Fructus,
    European Medicines Agency: EMA: Avenae Herba,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH365240,
    References:
    Brain / Mental Clarity: KENNEDY, D. O.; JACKSON, P. A.; FORSTER, J.; KHAN, J.; GROTHE, T.; PERRINJAQUET-MOCCETTI, T.; HASKELL-RAMSAY, C. F. Acute effects of a wild green-oat (Avena sativa) extract on cognitive function in middle-aged adults: a double-blind, placebo-controlled, within-subjects trial. Nutritional neuroscience, 2017, 20.2: 135-151. PMID:26618715, BERRY, N. M.; ROBINSON, M. J.; BRYAN, J.; BUCKLEY, J. D.; MURPHY, K. J.; HOWE, P. R. Acute effects of an Avena sativa herb extract on responses to the stroop color–word test. The Journal of Alternative and Complementary Medicine, 2011, 17.7: 635-637. PMID:21711204.
    
    
• Teanina (C₇H₁₄N₂O₃)
  L-teanina, znajdująca się w zielonej i czarnej herbacie, jest aminokwasem, który może pomóc złagodzić stres, jednocześnie stymulując neuroprzekaźniki w mózgu, tworząc uczucie relaksu, ale i wzmagając czujność.
  Teanina: L-Theanine, Theanine, Suntheanine, Theanin, N-Ethyl-L-Glutamine,
  PubChem CID: 439378,
  Chemical Abstracts Service: CAS: 3081-61-6,
  ChemIDplus: 3081-61-6,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS3519C0,
  References:
  Brain / Mental Clarity: PARK, H. K.; JUNG, I. C.; LEE, W. K.; LEE, Y. S.; GO, H. J.; KIM, K.; LIM, N. K.; HONG, J. T.; LY, S. Y.; RHO, S. S. A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. Journal of medicinal food, 2011, 14.4: 334-343. PMID:21303262, WHITE, D. J.; DE KLERK, S.; WOODS, W.; GONDALIA, S.; NOONAN, C.; SCHOLEY, A. B. Anti-stress, behavioural and magnetoencephalography effects of an l-theanine-based nutrient drink: a randomised, double-blind, placebo-controlled, crossover trial. Nutrients, 2016, 8.1: 53. PMID:26797633.
  
• L-tyrozyna (C₉H₁₁NO₃)
  L-tyrozyna, inny aminokwas, bierze udział w wytwarzaniu dopaminy i noradrenaliny; neuroprzekaźniki, które odgrywają kluczową rolę w czujności i skupieniu, szczególnie w sytuacjach stresowych. W rezultacie uważa się, że L-tyrozyna pomaga poprawić sprawność poznawczą, zmniejszając wpływ stresu i zmęczenia na wydajność i ułatwiając koncentrację.
  L-tyrozyna: Tyrosine, L-Tyrosine, P-Tyrosine, 4-Hydroxyphenylalanine,
  PubChem CID: 6057,
  Chemical Abstracts Service: CAS: 60-18-4,
  ChemIDplus: 60-18-4,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS27AC40,
  References:
  Brain / Mental Clarity: STEENBERGEN, L.; SELLARO, R.; HOMMEL, B.; COLZATO, L. S. Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance. Neuropsychologia, 2015, 69: 50-55. PMID:25598314, HENSEL, C.; BECKER, M.; DüZEL, S.; DEMUTH, I.; NORMAN, K.; STEINHAGEN-THIESSEN, E.; GALLINAT, J.; LINDENBERGER, U.; KüHN, S. Influence of nutritional tyrosine on cognition and functional connectivity in healthy old humans. NeuroImage, 2019. PMID:30853567.
  
• Resweratrol (C₁₄H₁₂O₃)
  Resweratrol: Resveratrol, Trans-Resveratrol, Resvida,
  PubChem CID: 445154,
  Chemical Abstracts Service: CAS: 501-36-0,
  ChemIDplus: 501-36-0,
  FDA Substance Registration System – Unique Ingredient Identifier: UNII: Q369O8926L,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS37B1D0,
  References:
  Brain / Mental Clarity: CAO, Wenyan; DOU, Ying; LI, Aiping Resveratrol boosts cognitive function by targeting SIRT1. Neurochemical research, 2018, 43.9: 1705-1713. PMID:29943083, MARX, Wolfgang; KELLY, J. T.; MARSHALL, S.; CUTAJAR, J.; ANNOIS, B.; PIPINGAS, A.; TIERNEY, A.; ITSIOPOULOS, C. Effect of resveratrol supplementation on cognitive performance and mood in adults: a systematic literature review and meta-analysis of randomized controlled trials. Nutrition reviews, 2018, 76.6: 432-443. PMID:29596658.
  
• Pterostilbene (C₁₆H₁₆O₃)
  Pterostilbene: Pterostilbene, Trans-Pterostilbene, Pterostilben,
  PubChem CID: 5281727,
  Chemical Abstracts Service: CAS: 537-42-8,
  ChemIDplus: 537-42-8,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS3A49E0,
  References:
  Brain / Mental Clarity: ESTRELA, Jose M.; ORTEGA, A.; MENA, S.; RODRIGUEZ, M. L.; ASENSI, M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences, 2013, 50.3: 65-78. PMID:23808710, JOSEPH, James A.; FISHER, D. R.; CHENG, V.; RIMANDO, A. M.; SHUKITT-HALE, B. Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging. Journal of agricultural and food chemistry, 2008, 56.22: 10544-10551. PMID:18954071.
  
• Magnez (Stearynian Magnezu) (C₃₆H₇₀MgO₄ or Mg(C₁₈H₃₅O₂)₂)
  Magnez (Stearynian Magnezu): Magnesium Stearate, Magnesium Octadecanoate, Magnesium Distearate, Synpro 90, Stearic acid, magnesium salt, Magnesium Dioctadecanoate,
  PubChem CID: 11177,
  Chemical Abstracts Service: CAS: 557-04-0,
  ChemIDplus: 557-04-0,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS371590-2,
  References:
  Brain / Mental Clarity: BOURRE, Jean-Marie Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients. Journal of Nutrition Health and Aging, 2006, 10.5: 377. PMID:17066209, HUSKISSON, E.; MAGGINI, S.; RUF, M. The influence of micronutrients on cognitive function and performance. Journal of international medical research, 2007, 35.1: 1-19. PMID:17408051.