Xu W. A., Gao Z. X., Weng Z., Du Z. M., Yang J. S., Zhang M. L., Tong Z. H., Fang Y. S., Chai X. S.
Acta pharmacologica Sinica, 1995
Abstract
Aim
To evaluate the efficacy and safety of tablet huperzine-A (Hup) in patients with Alzheimer's disease.
Methods
Using multicenter, prospective, double-blind, parallel, placebo controlled and randomized method, 50 patients were administered orally 0.2 mg (4 tablets) Hup and 53 patients were given po 4 tablets of placebo bid for 8 wk. All patients were evaluated with Hamilton's rating scale of depression, narration subtest of Wechsler memory scale, Hasegawa dementia scale, mini-mental state examination scale, activity of daily living scale, treatment emergency symptom scale, and measured with BP, HR, ECG, EEG, ALT, AKP, BUN, Cr, Hb, WBC, and urine routine.
Results
About 58% (29/50) of patients treated with Hup showed improvements in their memory (P < 0.01), cognitive (P < 0.01), and behavioral (P < 0.01 functions. The efficacy of Hup was better than placebo (36%, 19/53) (P < 0.05). No severe side effect was found.
Conclusion
Hup is a promising drug for symptomatic treatment of Alzheimer's disease.
| PMID: | 8701750 |
|---|---|
| Category: | Brain / Mental Clarity |
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