Yue Jirong, Dong B. R., Lin X., Yang M., Wu T.
Cochrane Database of Systematic Reviews, 2012
Abstract
Background
Mild cognitive impairment (MCI) has been proposed as a condition of intermediate symptomatology between the cognitive changes of ageing and fully developed symptoms of dementia. Treatment in the stages of MCI may delay the deterioration of cognitive impairment and delay the progression to dementia. Currently, the treatments for Alzheimer's disease have been focused on increasing acetylcholine levels in the brain. However, these drugs have not been proven to be effective for MCI and have numerous side effects. Huperzine A may have some beneficial effects in MCI.
Objectives
To assess the clinical efficacy and safety of huperzine A for the treatment of patients with MCI.
Search Methods
We searched ALOIS: the Cochrane Dementia and Cognitive Improvement Group's Specialized Register on 23 May 2011 using the terms: huperzine, ayapin, scoparon. ALOIS contains records of clinical trials identified from monthly searches of a number of major healthcare databases, numerous trial registries and grey literature sources. Additional searches were also performed separately in MEDLINE, EMBASE, PsycINFO, LILACS, clinicalTrials.gov, the ICTRP (WHO portal), CENTRAL (The Cochrane Library) and Web of Science with Conference Proceedings.The following Chinese databases were searched: The Chinese Biomedical Database, VIP Chinese Science and Technique Journals Database, China National Knowledge Infrastructure and The Chinese Clinical Trials Register. In addition, we handsearched 20 Chinese traditional medicine journals from between 1970 and 1989.
Selection Criteria
Randomised, parallel-group, placebo-controlled trials comparing huperzine A with placebo in patients with MCI were eligible for inclusion.
Data Collection And Analysis
Two review authors independently assessed studies for their eligibility for inclusion.
Main Results
No eligible trials were identified. In the absence of any suitable randomised placebo-controlled trials in this area, we were unable to perform a meta-analysis.
Authors' Conclusions
The currently available evidence is insufficient to assess the potential for huperzine A in the treatment of MCI. Randomised double-blind placebo-controlled trials are needed.
| PMID: | 23235666 |
|---|---|
| Category: | Brain / Mental Clarity |
The best supplements with Selagine in Brain / Mental Clarity category:
- NooCube - NooCube is a synergistic blend of nootropics which helps support and enhance your focus, mental speed and memory. It contains among others: Selagine.
- Brain Pill - „An amazing new product that supports your brain health and has the potential to change your life returning laser-sharp mental clarity” - Dr Dave David, a surgeon and physician for more than 37 years. It contains among others: Selagine.
- Pure Nootropics Huperzine A Capsules - Huperzine A is an alkaloid chemical compound extracted from the Chinese herb Huperzia serrata. It contains among others: Selagine.
Articles similar to "An update on huperzine A as a treatment for Alzheimer's disease."
- The significance of Selagine for Brain / Mental Clarity: Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. (AIM: To study the efficacy of huperzine-A capsules (Hup) on memory and learning performance of adolescent students... The Hup capsules enhance the memory and learning performance of adolescent students.)
- The role of Selagine in Brain / Mental Clarity: Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. (AIM: To evaluate the efficacy and safety of tablet huperzine-A (Hup) in patients with Alzheimer's disease... Hup is a promising drug for symptomatic treatment of Alzheimer's disease.)
- The impact of Selagine on Brain / Mental Clarity: Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine 1. (Huperzine A (HupA), a novel alkaloid isolated from the Chinese herb Huperzia serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase(AChE)... Hup is a promising drug for symptomatic treatment of Alzheimer's disease.)
- The significance of Selagine for Brain / Mental Clarity: Enantiomer effects of huperzine A on the aryl acylamidase activity of human cholinesterases. (1... Hup is a promising drug for symptomatic treatment of Alzheimer's disease.)
- The role of Selagine in Brain / Mental Clarity: Huperzine A, a potential therapeutic agent for treatment of Alzheimer's disease. (HupA is a potent, reversible and selective inhibitor of AChE with a rapid absorption and penetration into the brain in animal tests... Hup is a promising drug for symptomatic treatment of Alzheimer's disease.)
- The impact of Selagine on Brain / Mental Clarity: An update on huperzine A as a treatment for Alzheimer's disease. (Huperzine A is a natural cholinesterase inhibitor derived from the Chinese herb Huperzia serrata... Hup is a promising drug for symptomatic treatment of Alzheimer's disease.)
Previous article
An update on huperzine A as a treatment for Alzheimer's disease.
Next article
Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue.