Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine 1.

Wang Rui, Yan Han, Tang Xi-Can
Acta Pharmacologica Sinica, 2006

Abstract

Huperzine A (HupA), a novel alkaloid isolated from the Chinese herb Huperzia serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase(AChE). Compared with tacrine, donepezil, and rivastigmine, HupA has better penetration through the blood-brain barrier, higher oral bioavailability, and longer duration of AChE inhibitory action. HupA has been found to improve cognitive deficits in a broad range of animal models. HupA possesses the ability to protect cells against hydrogen peroxide, beta-amyloid protein (or peptide), glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. These protective effects are related to its ability to attenuate oxidative stress, regulate the expression of apoptotic proteins Bcl-2, Bax, P53, and caspase-3, protect mitochondria, upregulate nerve growth factor and its receptors, and interfere with amyloid precursor protein metabolism. Antagonizing effects of HupA on N-methyl-D-aspartate receptors and potassium currents may also contribute to its neuroprotection as well. Pharmacokinetic studies in rodents, canines, and healthy human volunteers indicated that HupA was absorbed rapidly, distributed widely in the body, and eliminated at a moderate rate with the property of slow and prolonged release after oral administration. Animal and clinical safety tests showed that HupA had no unexpected toxicity, particularly the dose-limiting hepatotoxicity induced by tacrine. The phase IV clinical trials in China have demonstrated that HupA significantly improved memory deficits in elderly people with benign senescent forgetfulness, and patients with Alzheimer disease and vascular dementia, with minimal peripheral cholinergic side effects and no unexpected toxicity. HupA can also be used as a protective agent against organophosphate intoxication.

PMID:16364207
Category:Brain / Mental Clarity

The best supplements with Selagine in Brain / Mental Clarity category:

  • NooCube - NooCube is a synergistic blend of nootropics which helps support and enhance your focus, mental speed and memory. It contains among others: Selagine.
  • Brain Pill - „An amazing new product that supports your brain health and has the potential to change your life returning laser-sharp mental clarity” - Dr Dave David, a surgeon and physician for more than 37 years. It contains among others: Selagine.
  • Pure Nootropics Huperzine A Capsules - Huperzine A is an alkaloid chemical compound extracted from the Chinese herb Huperzia serrata. It contains among others: Selagine.

Articles similar to "Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine 1."

Previous article

Citicoline: pharmacological and clinical review, 2010 update.

Next article

Effects of Ginkgo biloba on mental functioning in healthy volunteers.