Hensel C., Becker M., Düzel S., Demuth I., Norman K., Steinhagen-Thiessen E., Gallinat J., Lindenberger U., Kühn S.
NeuroImage, 2019
Abstract
Tyrosine is precursor for monoamine neurotransmitters such as dopamine (DA), which is one of the key neurotransmitters in the frontostriatal network and of crucial relevance for mental disorders. Recent research reported that high dose tyrosine application resulted in increased brain DA synthesis, which is consistent with the observation of positive associations between daily tyrosine intake and cognitive test performance. In the present study, we investigated the associations between working memory (WM) dependent tasks and self-reported nutritional tyrosine intake within a large group of healthy elderly humans (286 subjects) by additionally including brain functional data. We observed a negative correlation between tyrosine intake and resting-state functional connectivity (rsFC) between the striatum (putamen) and the prefrontal cortex. That is to say, we found higher rsFC in individuals consuming less tyrosine per day. At the same time, this increased rsFC or hyperconnectivity was associated with lower WM performance. These findings suggest that lower or insufficient supply of tyrosine might result in dysfunctional connectivity between striatal and frontal regions leading to lower WM capacity in healthy elderly humans.
| PMID: | 30853567 |
|---|---|
| Category: | Brain / Mental Clarity |
The best supplements with Tyrosine in Brain / Mental Clarity category:
- L-Tyrosine, Extra Strength, 750 mg, 90 Veg Capsules (Now Foods) - L-Tyrosine is a conditionally indispensable amino acid required for the production of the neurotransmitters dopamine, adrenaline, and noradrenaline, as well as for the skin pigment, melanin. It contains among others: Tyrosine.
- L-Tyrosine, 500 mg, 120 Capsules (Now Foods) - L-Tyrosine is a conditionally indispensable amino acid required for the production of the neurotransmitters dopamine, adrenaline, and noradrenaline, as well as for the skin pigment, melanin. It contains among others: Tyrosine.
- NooCube - NooCube is a synergistic blend of nootropics which helps support and enhance your focus, mental speed and memory. It contains among others: Tyrosine.
- Brain Pill - „An amazing new product that supports your brain health and has the potential to change your life returning laser-sharp mental clarity” - Dr Dave David, a surgeon and physician for more than 37 years. It contains among others: Tyrosine.
Articles similar to "Influence of nutritional tyrosine on cognition and functional connectivity in healthy old humans."
- The significance of Tyrosine for Brain / Mental Clarity: Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance. (Tyrosine (TYR), an amino acid found in various foods, has been shown to increase dopamine (DA) levels in the brain...)
- The impact of Tyrosine on Brain / Mental Clarity: Working memory reloaded: tyrosine repletes updating in the N-back task. (In this study we tested the idea that the food supplement l-Tyrosine (TYR) repletes resources required for cognitive-control operations...)
- The significance of Tyrosine for Brain / Mental Clarity: Effects of tyrosine, phentermine, caffeine D-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation. (Cognitive and motor performance are critical in many circumstances and are impaired by sleep deprivation...)
- The role of Tyrosine in Brain / Mental Clarity: Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. (Acutely stressful situations can disrupt behavior and deplete brain norepinephrine and dopamine, catecholaminergic neurotransmitters...)