Brain Actives

Brain Actives – Ingredients

• Performance & Energy Booster
  
• Theacrine – TeaCrine® (125 Mg)
  • TeaCrine® (C₉H₁₂N₄O₃)
    TeaCrine® unleashes your maximum potential. It is an extremely effective in combination with caffeine. Does not cause irritation or the caffeine crash. Regardless of whether you expect support in mental effort or during training in the gym, TeaCrine® supports you just as effectively.
    TeaCrine®: Theacrine, Tetramethyluric Acid, Temurin, Temorine, 1,3,7,9-Tetramethyluric Acid, Tetramethyl Uric Acid, PubChem CID: 75324, Chemical Abstracts Service: CAS: 2309-49-1, ChemIDplus: 2309-49-1, FDA Substance Registration System – Unique Ingredient Identifier: UNII: EJ939L81MY, The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISAA22B0, References: Brain / Mental Clarity: ZIEGENFUSS, Tim N.; et al. A Two-Part Approach to Examine the Effects of Theacrine (TeaCrine®) Supplementation on Oxygen Consumption, Hemodynamic Responses, and Subjective Measures of Cognitive and Psychometric Parameters. Journal of dietary supplements, 2017, 14.1: 9-24. PMID:27164220, TAYLOR, Lem; et al. Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use. Journal of the International Society of Sports Nutrition, 2016, 13.1: 2. PMID:26766930.
    
• Natural Caffeine Anhydrous (150 Mg)
  • Caffeine (C₈H₁₀N₄O₂)
    Caffeine: accelerates response time, reduces fatigue, increases physical endurance, helps to increase alertness.
    Caffeine: Caffeine, 1,3,7-Trimethylxanthine, Thein,
    PubChem CID: 2519,
    Chemical Abstracts Service: CAS: 58-08-2,
    ChemIDplus: 58-08-2,
    WHO Anatomical Therapeutic Chemical Classification System: ATC code: N06BC01,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS2C8E40,
    References:
    Brain / Mental Clarity: BELLO, Marissa L.; et al. The effects of TeaCrine® and caffeine on endurance and cognitive performance during a simulated match in high-level soccer players. Journal of the International Society of Sports Nutrition, 2019, 16.1: 20. PMID:30999897, DIETZ, Christina; DEKKER, Matthijs Effect of Green Tea Phytochemicals on Mood and Cognition. Current pharmaceutical design, 2017, 23.19: 2876-2905. PMID:28056735.
    
• Cognitive & Nootropic Complex
  
• Ashwagandha Root Extract [5% Withanolides] – KSM-66® (300 Mg)
  • Ashwagandha (Withania Somnifera)
    Ashwagandha: improves memory, increases learning ability, supports cognitive ability, increase focus, helps reduce stress, build energy, improve muscle function. Species: Withania Somnifera,
    Family: Solanaceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH9BA3C0,
    References:
    Brain / Mental Clarity: ANDRADE, Chittaranjan; et al. A double-blind, placebo-controlled evaluation of the anxiolytic efficacy ff an ethanolic extract of withania somnifera. Indian journal of psychiatry, 2000, 42.3: 295. PMID:21407960, YENISETTI, Sarat; et al. Neuropharmacological Properties of Withania somnifera – Indian Ginseng: An Overview on Experimental Evidence with Emphasis on Clinical Trials and Patents. Recent patents on CNS drug discovery, 2015, 10.2: 204-215. PMID:27316579,
    Stress / Relaxation: CHANDRASEKHAR, K.; KAPOOR, Jyoti; ANISHETTY, Sridhar A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine, 2012, 34.3: 255. PMID:23439798, SALVE, Jaysing; et al. Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus, 2019, 11.12: e6466. PMID:32021735.
    
    
  • KSM-66®
    KSM-66®: KSM-66®, The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISAA49C0, References: Sports Nutrition: CHOUDHARY, Bakhtiar; SHETTY, A.; LANGADE, Deepak G. Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults. Ayu, 2015, 36.1: 63. PMID:26730141.
    
• Bacopa Monnieri Herb Extract [50% Bacosides] – Bacopin® (150 Mg)
  • Bacopa Monnieri (Bacopa Monnieri)
    Helps to absorb knowledge, strengthens the ability to concentrate, improves brain function, improves cognitive functions. The indian herb Bacopa monnieri contains compounds called bacosides which are thought to help repair damaged neurons and promote new nerve growth. This improves neuron communication with the brain, helping improve your cognitive function and mental performance. Species: Bacopa Monnieri,
    Family: Plantaginaceae,
    Domain: Plantae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH358EF0,
    References:
    Brain / Mental Clarity: MCPHEE, G. M.; DOWNEY, L. A.; NOBLE, A.; STOUGH, C. Cognitive training and Bacopa monnieri: Evidence for a combined intervention to alleviate age associated cognitive decline. Medical hypotheses, 2016, 95: 71-76. PMID:27692172, MORGAN, A.; STEVENS, J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. The journal of alternative and complementary medicine, 2010, 16.7: 753-759. PMID:20590480.
    
    
  • Bacopin®
    Bacopin®: Bacopin®, The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISAA70D0.
    
• Gotu Kola Leaf Extract [8% Triterpenes] – Centellin® (50 Mg)
  • Gotu Kola (Centella Asiatica)
    Gotu Kola: known nootropic, revitalizes brain and nervous system, increases attention span, improves long term memory. Species: Centella Asiatica,
    Family: Apiaceae Mackinlayaceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH4FA6A0,
    References:
    Brain / Mental Clarity: PUTTARAK, Panupong; et al. Effects of Centella asiatica (L.) Urb. on cognitive function and mood related outcomes: A Systematic Review and Meta-analysis. Scientific reports, 2017, 7.1: 10646. PMID:28878245, SHINOMOL, G. K.; et al. Exploring the Role of “Brahmi” (Bacopa monnieri and Centella asiatica) in Brain Function and Therapy. Recent patents on endocrine, metabolic & immune drug discovery, 2011, 5.1: 33-49. PMID:22074576,
    Cardiovascular Support: RAZALI, Nur Nadia Mohd; NG, Chin Theng; FONG, Lai Yen Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review. Planta medica, 2019, 85.16: 1203-1215. PMID:31539918.
    
    
  • Centellin®
    Centellin®: Centellin®, The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS2D2A80.
    
  • Triterpenes (C₃₀H₄₈)
    Triterpenes: Triterpenes, Triterpene, The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS391160.
    
    • Madecassol (C₄₈H₇₈O₁₉)
      Madecassol: Madecassol, Asiaticoside, Centelase, Blastostimulina,
      PubChem CID: 11954171,
      Chemical Abstracts Service: CAS: 16830-15-2,
      ChemIDplus: 16830-15-2,
      FDA Substance Registration System – Unique Ingredient Identifier: UNII: PKO39VY215,
      The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISEDBB60.
      
    • Brahmoside
      Brahmoside: Brahmoside, Brahminoside, PubChem CID: 395762, The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISED9450.
      
    • Asiatic Acid (C₃₀H₄₈O₅)
      Asiatic Acid: Asiatic Acid, Asiantic Acid, Dammarolic Acid,
      PubChem CID: 119034,
      Chemical Abstracts Service: CAS: 464-92-6,
      ChemIDplus: 464-92-6,
      FDA Substance Registration System – Unique Ingredient Identifier: UNII: 9PA5A687X5,
      The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISED6D40.
      
    • Madecassic Acid (C₃₀H₄₈O₆)
      Madecassic Acid: Madecassic Acid, Brahmic Acid, 6Beta-Hydroxyasiatic Acid,
      PubChem CID: 73412,
      Chemical Abstracts Service: CAS: 18449-41-7,
      ChemIDplus: 18449-41-7,
      FDA Substance Registration System – Unique Ingredient Identifier: UNII: M7O1N24J82,
      The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISED4630.
      
• Black Pepper Fruit Extract [95% Piperine] – BioPerine® (5 Mg)
  • Black Pepper (Piper Nigrum)Species: Piper Nigrum,
    Family: Piperaceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2CB550,
    References:
    Brain / Mental Clarity: JOSHI, Hanumanthachar; PARLE, Milind Effects of piperine on memory and behavior mediated via monoamine neurotransmiters. Journal of Traditional Medicines, 2005, 22.2+ 3: 39-43., NEWERLI-GUZ, Joanna; ŚMIECHOWSKA, Maria Assessment of the contents of piperine in black pepper berries Piper nigrum L. Bromatologia i Chemia Toksykologiczna, 2009, XLII: 827–830..
    
    
  • BioPerine®
    BioPerine® is an innovative form of piperine devoid of chemicals used for growing plants such as: fertilizers, concentrates, nutrients, pesticides or other plant protection products. The safety of its use has been confirmed by the European Food Safety Authority (EFSA). Thanks to better absorption, in comparison to the conventional form, and the use of this form, a significant increase in bioavailability of other valuable components of this supplement is observed. This even leads to a 30-fold increase in its effects. In addition, BioPerine® contains more piperine than black pepper extract, which further intensifies the effectiveness of the product.
    BioPerine®: BioPerine®,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS28E4C0.
    
  • Piperine (C₁₇H₁₉NO₃)
    Piperine: Piperine, Bioperine, Piperin, 1-Piperoylpiperidine, Piperoylpiperidine, 1-Piperylpiperidine,
    PubChem CID: 638024,
    Chemical Abstracts Service: CAS: 94-62-2,
    ChemIDplus: 94-62-2,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS395F80,
    References:
    Brain / Mental Clarity: JOSHI, Hanumanthachar; PARLE, Milind Effects of piperine on memory and behavior mediated via monoamine neurotransmiters. Journal of Traditional Medicines, 2005, 22.2+ 3: 39-43..
    
• Neuro Vita-Min Blend
  
• Vitamin B6 (14 Mg)
  • Vitamin B6 (Pyridoxine) (C₈H₁₁NO₃)
    Required for the biosynthesis of several neurotransmitters including dopamine, serotonin, and GABA. CILTEP features the metabolically active form of vitamin B-6 (Pyridoxal-5-Phosphate) to ensure optimal cognitive function. Low dietary intake or reduced blood concentrations of vitamin B6 is associated with an increased risk of cardiovascular disease.
    Vitamin B6 (Pyridoxine): Pyridoxine, Gravidox, Pyridoxol, Vitamin B6,
    PubChem CID: 1054,
    Chemical Abstracts Service: CAS: 65-23-6,
    ChemIDplus: 65-23-6,
    WHO Anatomical Therapeutic Chemical Classification System: ATC code: A11HA02,
    FDA Substance Registration System – Unique Ingredient Identifier: UNII: KV2JZ1BI6Z,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS264CB0,
    References:
    Cardiovascular Support: FRISO, Simonetta; et al. Vitamin B6 and Cardiovascular Disease. In: Water Soluble Vitamins. Springer, Dordrecht, 2012, 56: 265-290. PMID:22116704, JEON, Jimin; PARK, Kyong Dietary Vitamin B 6 Intake Associated With a Decreased Risk of Cardiovascular Disease: A Prospective Cohort Study. Nutrients, 2019, 11.7: 1484. PMID:31261898,
    Brain / Mental Clarity: BOURRE, Jean-Marie Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients. Journal of Nutrition Health and Aging, 2006, 10.5: 377. PMID:17066209, RAMOS, Rúben J.; et al. Vitamin B6 Is Essential for Serine De Novo Biosynthesis. Journal of inherited metabolic disease, 2017, 40.6: 883-891. PMID:28801717,
    Stress / Relaxation: POUTEAU, Etienne; et al. Superiority of Magnesium and Vitamin B6 Over Magnesium Alone on Severe Stress in Healthy Adults With Low Magnesemia: A Randomized, Single-Blind Clinical Trial. PloS one, 2018, 13.12: e0208454. PMID:30562392, KELLY, Gregory S. Nutritional and Botanical Interventions to Assist With the Adaptation to Stress. Alternative medicine review: a journal of clinical therapeutic, 1999, 4.4: 249-265. PMID:10468649,
    Sports Nutrition: MANORE, Melinda M. Vitamin B6 and Exercise. International Journal of Sport Nutrition and Exercise Metabolism, 1994, 4.2: 89-103. PMID:8054964.
    
• Vitamin B12 (25 μg)
  • Vitamin B12 (cobalamin, cyanocobalamin) (C₆₃H₈₈CoN₁₄O₁₄P)
    Vitamin B12 (cobalamin, cyanocobalamin): Cyanocobalamin, Vitamin B12, Cobalamin, Crystamine, Anacobin,
    PubChem CID: 5311498,
    Chemical Abstracts Service: CAS: 68-19-9,
    ChemIDplus: 68-19-9,
    WHO Anatomical Therapeutic Chemical Classification System: ATC code: B03BA01,
    FDA Substance Registration System – Unique Ingredient Identifier: UNII: P6YC3EG204,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS30D400,
    References:
    Brain / Mental Clarity: SMITH, A. David; WARREN, Martin J.; REFSUM, Helga Vitamin B12. In: Advances in food and nutrition research. Academic Press, 2018, 2018: 215-279. PMID:29477223, TANGNEY, C. C.; AGGARWAL, N. T.; LI, H.; WILSON, R. S.; DECARLI, C.; EVANS, D. A.; MORRIS, M. C. Vitamin B12, cognition, and brain MRI measures: a cross-sectional examination. Neurology, 2011, 77.13: 1276-1282. PMID:21947532,
    Stress / Relaxation: KELLY, Gregory S. Nutritional and Botanical Interventions to Assist With the Adaptation to Stress. Alternative medicine review: a journal of clinical therapeutic, 1999, 4.4: 249-265. PMID:10468649.
    
• Pantothenic Acid (15 Mg)
  • Vitamin B5 (Pantothenic Acid) (C₉H₁₇NO₅)
    Vitamin B5 (Pantothenic Acid): D-Pantothenic Acid, Vitamin B5, Pantothenic Acid, Pantothenate,
    PubChem CID: 6613,
    Chemical Abstracts Service: CAS: 79-83-4,
    ChemIDplus: 79-83-4,
    WHO Anatomical Therapeutic Chemical Classification System: ATC code: A11HA31,
    FDA Substance Registration System – Unique Ingredient Identifier: UNII: 19F5HK2737,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS26C1E0,
    References:
    Brain / Mental Clarity: KENNEDY, David O. B Vitamins and the Brain: Mechanisms, Dose and Efficacy–A Review. Nutrients, 2016, 8.2: 68. PMID:26828517,
    Stress / Relaxation: KELLY, Gregory S. Nutritional and Botanical Interventions to Assist With the Adaptation to Stress. Alternative medicine review: a journal of clinical therapeutic, 1999, 4.4: 249-265. PMID:10468649.
    
• Magnesium – Aquamin™ Mg (75 Mg)
  • Magnesium (Mg)
    Magnesium: Magnesium, PubChem CID: 5462224, Chemical Abstracts Service: CAS: 7439-95-4, ChemIDplus: 7439-95-4, The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS371590, References: Brain / Mental Clarity: BOURRE, Jean-Marie Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients. Journal of Nutrition Health and Aging, 2006, 10.5: 377. PMID:17066209, HUSKISSON, E.; MAGGINI, S.; RUF, M. The influence of micronutrients on cognitive function and performance. Journal of international medical research, 2007, 35.1: 1-19. PMID:17408051, Stress / Relaxation: POUTEAU, Etienne; et al. Superiority of Magnesium and Vitamin B6 Over Magnesium Alone on Severe Stress in Healthy Adults With Low Magnesemia: A Randomized, Single-Blind Clinical Trial. PloS one, 2018, 13.12: e0208454. PMID:30562392, Sports Nutrition: CINAR, Vedat; et al. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion. Biological trace element research, 2011, 140.1: 18-23. PMID:20352370.