NooCube

NooCube – Ingredients

• Alpha Glycerylphosphorylcholine (C₈H₂₀NO₆P)
  Alpha Glycerylphosphorylcholine (Alpha GPC) is thought to increase levels of acetylcholine in the brain. Acetylcholine is a neurotransmitter – chemical messengers that communicate between brain cells. It is important for memory, learning and concentration, which is why it is known as the learning neurotransmitter. Alpha GPC has demonstrated such a strong ability to improve cognitive function, it is considered a possible treatment for Alzheimer’s disease.
  Alpha Glycerylphosphorylcholine: Choline Glycerophosphate, Alpha-Glycerylphosphorylcholine, Colina Glicerofosfato, Cholini Glycerophosphas, Cholini Alfosceras, Alpha-GPC,
  PubChem CID: 71920,
  Chemical Abstracts Service: CAS: 28319-77-9,
  ChemIDplus: 28319-77-9,
  WHO Anatomical Therapeutic Chemical Classification System: ATC code: N07AX02,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS360420,
  References:
  Brain / Mental Clarity: MORENO, Maria De Jesus Cognitive improvement in mild to moderate Alzheimer’s dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial. Clinical therapeutics, 2003, 25.1: 178-193. PMID:12637119, DI PERRI, R.; COPPOLA, G.; AMBROSIO, L. A.; GRASSO, A.; PUCA, F. M.; RIZZO, M. A multicentre trial to evaluate the efficacy and tolerability of α-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. Journal of international medical research, 1991, 19.4: 330-341. PMID:1916007.
  
• Toothed Clubmoss (0.5% Huperzine-A)
  • Toothed Clubmoss (Huperzia Serrata)Species: Huperzia Serrata,
    Family: Lycopodiaceae,
    Domain: Plantae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH3A22D0,
    References:
    Brain / Mental Clarity: HUANG, Ji; ZHAO, Ailing Analysis of dynamic change of huperzine A content in Huperzia serrata. China journal of Chinese materia medica, 2010, 35.19: 2511-2515. PMID:21174755.
    
    
  • Huperzine A (C₁₅H₁₈N₂O)
    An extract from the Chinese club moss plant, Huperzine-A is an acetylcholinesterase (AChE) inhibitor. AChE breaks down the learning neurotransmitter acetylcholine. By preventing acetylcholine levels from decreasing, Huperzine A creates a surplus of acetylcholine, which can lead to improved mental clarity, concentration and memory.
    Huperzine A: Selagine, HupA,
    PubChem CID: 854026,
    Chemical Abstracts Service: CAS: 102518-79-6,
    ChemIDplus: 102518-79-6,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS345670,
    References:
    Brain / Mental Clarity: SUN, Q. Q.; XU, S. S.; PAN, J. L.; GUO, H. M.; CAO, W. Q. Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Acta pharmacologica Sinica, 1999, 20.7: 601-603. PMID:10678121, XU, W. A.; GAO, Z. X.; WENG, Z.; DU, Z. M.; YANG, J. S.; ZHANG, M. L.; TONG, Z. H.; FANG, Y. S.; CHAI, X. S. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer’s disease. Acta pharmacologica Sinica, 1995, 16.5: 391-395. PMID:8701750.
    
• Cat’s Claw 4:1 Concentrated Extract
  • Cat’s Claw (Uncaria Tomentosa)
    Derived naturally from Uncaria tomentosa, a vine that grows in the Amazon rainforest, Cat’s Claw is believed to have neuroprotective benefits. It contains antioxidants that can help enhance the body’s natural ability to repair environmental-stress related DNA damage to cells. Cat’s Claw can help improve your brain health and cognitive performance. Species: Uncaria Tomentosa,
    Family: Rubiaceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH362B30,
    References:
    Brain / Mental Clarity: SNOW, Alan D.; et al. The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles Scientific reports, 2019, 9.1: 561. PMID:30728442.
    
    
• Bacopin® (Bacopa Monnieri 12:1 Extract)
  • Bacopa (Bacopa Monnieri)
    Helps to absorb knowledge, strengthens the ability to concentrate, improves brain function, improves cognitive functions. The indian herb Bacopa monnieri contains compounds called bacosides which are thought to help repair damaged neurons and promote new nerve growth. This improves neuron communication with the brain, helping improve your cognitive function and mental performance. Species: Bacopa Monnieri,
    Family: Plantaginaceae,
    Domain: Plantae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH358EF0,
    References:
    Brain / Mental Clarity: MCPHEE, G. M.; DOWNEY, L. A.; NOBLE, A.; STOUGH, C. Cognitive training and Bacopa monnieri: Evidence for a combined intervention to alleviate age associated cognitive decline. Medical hypotheses, 2016, 95: 71-76. PMID:27692172, MORGAN, A.; STEVENS, J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. The journal of alternative and complementary medicine, 2010, 16.7: 753-759. PMID:20590480.
    
    
• Oat Straw Extract 10:1
  • Oat Straw (Avena Sativa)
    Also known as Avena sativa, Oat Straw comes from wild green oats and has been used as a brain booster in folk medicine since the Middle Ages. Oat straw is believed to work by increasing alpha-2 waves in the brain – which are highly active during periods of wakefulness – as well as controlling inflammation within artery walls. This increases blood flow to the brain, helping you feel more awake and alert. Species: Avena Sativa,
    Family: Poaceae,
    European Medicines Agency: EMA: Avenae Fructus,
    European Medicines Agency: EMA: Avenae Herba,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH365240,
    References:
    Brain / Mental Clarity: KENNEDY, D. O.; JACKSON, P. A.; FORSTER, J.; KHAN, J.; GROTHE, T.; PERRINJAQUET-MOCCETTI, T.; HASKELL-RAMSAY, C. F. Acute effects of a wild green-oat (Avena sativa) extract on cognitive function in middle-aged adults: a double-blind, placebo-controlled, within-subjects trial. Nutritional neuroscience, 2017, 20.2: 135-151. PMID:26618715, BERRY, N. M.; ROBINSON, M. J.; BRYAN, J.; BUCKLEY, J. D.; MURPHY, K. J.; HOWE, P. R. Acute effects of an Avena sativa herb extract on responses to the stroop color–word test. The Journal of Alternative and Complementary Medicine, 2011, 17.7: 635-637. PMID:21711204.
    
    
• Theanine (C₇H₁₄N₂O₃)
  Found in green and black tea, L-theanine is an amino acid that can help relieve stress while stimulating neurotransmitters in the brain, creating a relaxed but alert feeling.
  Theanine: L-Theanine, Suntheanine, Theanin, N-Ethyl-L-Glutamine,
  PubChem CID: 439378,
  Chemical Abstracts Service: CAS: 3081-61-6,
  ChemIDplus: 3081-61-6,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS3519C0,
  References:
  Brain / Mental Clarity: PARK, H. K.; JUNG, I. C.; LEE, W. K.; LEE, Y. S.; GO, H. J.; KIM, K.; LIM, N. K.; HONG, J. T.; LY, S. Y.; RHO, S. S. A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. Journal of medicinal food, 2011, 14.4: 334-343. PMID:21303262, WHITE, D. J.; DE KLERK, S.; WOODS, W.; GONDALIA, S.; NOONAN, C.; SCHOLEY, A. B. Anti-stress, behavioural and magnetoencephalography effects of an l-theanine-based nutrient drink: a randomised, double-blind, placebo-controlled, crossover trial. Nutrients, 2016, 8.1: 53. PMID:26797633.
  
• L-Tyrosine (C₉H₁₁NO₃)
  L-tyrosine, another amino acid, is involved in the manufacture of dopamine and noradrenaline; neurotransmitters that play a key role in mental alertness and focus, particularly in stressful situations. As a result, L-tyrosine is thought to help improve cognitive performance by reducing the effects of stress and fatigue on performance and making it easier to remain focused.
  L-Tyrosine: Tyrosine, P-Tyrosine, 4-Hydroxyphenylalanine,
  PubChem CID: 6057,
  Chemical Abstracts Service: CAS: 60-18-4,
  ChemIDplus: 60-18-4,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS27AC40,
  References:
  Brain / Mental Clarity: STEENBERGEN, L.; SELLARO, R.; HOMMEL, B.; COLZATO, L. S. Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance. Neuropsychologia, 2015, 69: 50-55. PMID:25598314, HENSEL, C.; BECKER, M.; DüZEL, S.; DEMUTH, I.; NORMAN, K.; STEINHAGEN-THIESSEN, E.; GALLINAT, J.; LINDENBERGER, U.; KüHN, S. Influence of nutritional tyrosine on cognition and functional connectivity in healthy old humans. NeuroImage, 2019. PMID:30853567.
  
• Resveratrol (C₁₄H₁₂O₃)
  Resveratrol: Resveratrol, Trans-Resveratrol, Resvida,
  PubChem CID: 445154,
  Chemical Abstracts Service: CAS: 501-36-0,
  ChemIDplus: 501-36-0,
  FDA Substance Registration System – Unique Ingredient Identifier: UNII: Q369O8926L,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS37B1D0,
  References:
  Brain / Mental Clarity: CAO, Wenyan; DOU, Ying; LI, Aiping Resveratrol boosts cognitive function by targeting SIRT1. Neurochemical research, 2018, 43.9: 1705-1713. PMID:29943083, MARX, Wolfgang; KELLY, J. T.; MARSHALL, S.; CUTAJAR, J.; ANNOIS, B.; PIPINGAS, A.; TIERNEY, A.; ITSIOPOULOS, C. Effect of resveratrol supplementation on cognitive performance and mood in adults: a systematic literature review and meta-analysis of randomized controlled trials. Nutrition reviews, 2018, 76.6: 432-443. PMID:29596658.
  
• Pterostilbene (C₁₆H₁₆O₃)
  Pterostilbene: Pterostilbene, Trans-Pterostilbene, Pterostilben,
  PubChem CID: 5281727,
  Chemical Abstracts Service: CAS: 537-42-8,
  ChemIDplus: 537-42-8,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS3A49E0,
  References:
  Brain / Mental Clarity: ESTRELA, Jose M.; ORTEGA, A.; MENA, S.; RODRIGUEZ, M. L.; ASENSI, M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences, 2013, 50.3: 65-78. PMID:23808710, JOSEPH, James A.; FISHER, D. R.; CHENG, V.; RIMANDO, A. M.; SHUKITT-HALE, B. Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging. Journal of agricultural and food chemistry, 2008, 56.22: 10544-10551. PMID:18954071.
  
• Magnesium (Magnesium Stearate) (C₃₆H₇₀MgO₄ or Mg(C₁₈H₃₅O₂)₂)
  Magnesium (Magnesium Stearate): Magnesium Stearate, Magnesium Octadecanoate, Magnesium Distearate, Synpro 90, Stearic acid, magnesium salt, Magnesium Dioctadecanoate,
  PubChem CID: 11177,
  Chemical Abstracts Service: CAS: 557-04-0,
  ChemIDplus: 557-04-0,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS371590-2,
  References:
  Brain / Mental Clarity: BOURRE, Jean-Marie Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients. Journal of Nutrition Health and Aging, 2006, 10.5: 377. PMID:17066209, HUSKISSON, E.; MAGGINI, S.; RUF, M. The influence of micronutrients on cognitive function and performance. Journal of international medical research, 2007, 35.1: 1-19. PMID:17408051.