Women's Health (Menopause)

Menopause - References & External links

The references to scientific articles about Menopause are not meant to imply that any products treat, cure, or diagnose any disease or human condition. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• The properties of Ascorbic Acid against Menopause syndrome:
  • MCCABE, Delia; et al. The Impact of Essential Fatty Acid, B Vitamins, Vitamin C, Magnesium and Zinc Supplementation on Stress Levels in Women: A Systematic Review. JBI database of systematic reviews and implementation reports, 2017, 15.2: 402-453. PMID:28178022
    Conclusion: The current review suggests that EFAs may be effective in reducing prenatal stress and salivary cortisol and may reduce anxiety during premenstrual syndrome and during menopause in the absence of depression. Magnesium and vitamin B6 may be effective in combination in reducing premenstrual stress, and vitamin B6 alone may reduce anxiety effectively in older women. High-dose sustained-release vitamin C may reduce anxiety and mitigate increased blood pressure in response to stress.
• The properties of Pyridoxine against Menopause syndrome:
  • MCCABE, Delia; et al. The Impact of Essential Fatty Acid, B Vitamins, Vitamin C, Magnesium and Zinc Supplementation on Stress Levels in Women: A Systematic Review. JBI database of systematic reviews and implementation reports, 2017, 15.2: 402-453. PMID:28178022
    Conclusion: The current review suggests that EFAs may be effective in reducing prenatal stress and salivary cortisol and may reduce anxiety during premenstrual syndrome and during menopause in the absence of depression. Magnesium and vitamin B6 may be effective in combination in reducing premenstrual stress, and vitamin B6 alone may reduce anxiety effectively in older women. High-dose sustained-release vitamin C may reduce anxiety and mitigate increased blood pressure in response to stress.
• The properties of Vitis Vinifera against Menopause syndrome:
  Grape seed proanthocyanidin extract is effective in improving the physical and psychological symptoms of menopause while increasing muscle mass and reducing blood pressure in middle-aged women.
  • TERAUCHI, Masakazu; et al. Effects of Grape Seed Proanthocyanidin Extract on Menopausal Symptoms, Body Composition, and Cardiovascular Parameters in Middle-Aged Women: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Menopause, 2014, 21.9: 990-996. PMID:24518152
    Conclusions: Grape seed proanthocyanidin extract is effective in improving the physical and psychological symptoms of menopause while increasing muscle mass and reducing blood pressure in middle-aged women.
  • WAHNER-ROEDLER, Dietlind L.; et al. The Effect of Grape Seed Extract on Estrogen Levels of Postmenopausal Women: A Pilot Study. Journal of dietary supplements, 2014, 11.2: 184-197. PMID:24670122
• The properties of Magnesium against Menopause syndrome:
  • MCCABE, Delia; et al. The Impact of Essential Fatty Acid, B Vitamins, Vitamin C, Magnesium and Zinc Supplementation on Stress Levels in Women: A Systematic Review. JBI database of systematic reviews and implementation reports, 2017, 15.2: 402-453. PMID:28178022
    Conclusion: The current review suggests that EFAs may be effective in reducing prenatal stress and salivary cortisol and may reduce anxiety during premenstrual syndrome and during menopause in the absence of depression. Magnesium and vitamin B6 may be effective in combination in reducing premenstrual stress, and vitamin B6 alone may reduce anxiety effectively in older women. High-dose sustained-release vitamin C may reduce anxiety and mitigate increased blood pressure in response to stress.
• The properties of Foeniculum Vulgare against Menopause syndrome:
  • MAHBOUBI, Mohaddese. Foeniculum vulgare as Valuable Plant in Management of Women's Health. Journal of menopausal medicine, 2019, 25.1: 1-14. PMID:31080784
• The properties of Trifolium Pratense against Menopause syndrome:
  RCE (Red Clover Extract) supplementation exerts a subject improvement of scalp hair and skin status as well as libido, mood, sleep, and tiredness in postmenopausal women.
  • MYERS, Stephen P.; VIGAR, Vanessa. Effects of a standardised extract of Trifolium pratense (Promensil) at a dosage of 80mg in the treatment of menopausal hot flushes: A systematic review and meta-analysis. Phytomedicine, 2017, 24: 141-147. PMID:28160855
    CONCLUSION: There is evidence for a statistical and clinically significant benefit for using a specific standardised extract of red clover isoflavones (Promensil) at 80mg/day for treating hot flushes in menopausal women across the 3 studies included in the meta-analysis. The preparation was safe over the short-term duration of the studies (3 months).
  • BUDRYN, Grażyna; et al. Evaluation of estrogenic activity of red clover (Trifolium pratense L.) sprouts cultivated under different conditions by content of isoflavones, calorimetric study and molecular modelling. Food chemistry, 2018, 245: 324-336. PMID:29287378
  • LAMBERT, Max Norman Tandrup; et al. Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms. PloS one, 2017, 12.6: e0176590. PMID:28591133
    CONCLUSION: Results suggest that moderate doses of RCE were more effective and superior to placebo in reducing physiological and self-reported VMS. Findings support that objective physiological symptom assessment methods should be used together with self-report measures in future studies on menopausal VMS. TRIAL REGISTRATION: ClinicalTrials.gov NCT02028702.
  • LUíS, Â; DOMINGUES, F.; PEREIRA, L. Effects of red clover on perimenopausal and postmenopausal women's blood lipid profile: A meta-analysis. Climacteric, 2018, 21.5: 446-453. PMID:30269660
  • SHAKERI, F.; et al. Effectiveness of red clover in alleviating menopausal symptoms: a 12-week randomized, controlled trial. Climacteric, 2015, 18.4: 568-573. PMID:25581426
    CONCLUSION: These results indicated that, compared to placebo, dried leaves of red clover were more effective in reducing the severity of menopausal symptoms in postmenopausal women.
  • LIPOVAC, Markus; et al. Red clover isoflavone metabolite bioavailability is decreased after fructooligosaccharide supplementation. Fitoterapia, 2015, 105: 93-101. PMID:26073948
    CONCLUSION: This study is the first to provide detailed data on RCI bioavailability in humans and determine no influence of FOS yet a trend toward increased equol production. More research is warranted involving a greater sample size.
  • CHEN, M. N.; LIN, C. C.; LIU, C. F. Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review. Climacteric, 2015, 18.2: 260-269. PMID:25263312
    CONCLUSION: Phytoestrogens appear to reduce the frequency of hot flushes in menopausal women, without serious side-effects.
  • GHAZANFARPOUR, Masumeh; et al. Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis. Avicenna journal of phytomedicine, 2015, 5.6: 498. PMID:26693407
    CONCLUSION: Red clover had a positive effect of alleviating hot flash in menopausal women. Our data, however, suggested very slight changes in FSH, LH, testosterone, and SHBG and significant effect in estrogen status by red clover consumption. However, the interpretation of results of the current study is limited due to methodological flaws of the included studies, menopause status, and large heterogeneity among them. Further trials are still needed to confirm the current finding.
• The properties of Lepidium Meyenii against Menopause syndrome:
  • BROOKS, Nicole A. Beneficial Effects of Lepidium Meyenii (Maca) on Psychological Symptoms and Measures of Sexual Dysfunction in Postmenopausal Women Are Not Related to Estrogen or Androgen Content. Menopause, 2008, 15.6: 1157-1162. PMID:18784609
    Conclusions: Preliminary findings show that Lepidium meyenii (Maca) (3.5 g/d) reduces psychological symptoms, including anxiety and depression, and lowers measures of sexual dysfunction in postmenopausal women independent of estrogenic and androgenic activity.
  • MEISSNER, H. O.; et al. Use of Gelatinized Maca (Lepidium Peruvianum) in Early Postmenopausal Women. International journal of biomedical science: IJBS, 2005, 1.1: 33. PMID:23674952
    Conclusions: It is reasonable to suggest that Maca-GO when used in EPMW, depending on the length of use, was acting as a toner of hormonal processes as reflected by decrease in FSH and increased LH secretion, which stimulated production of both ovarian hormones, E2 and PG and resulted in a substantial reduction of menopausal discomfort felt by women participating in the study, with a distinctive placebo effect, thus, fully justifying further, more complex study on effectiveness of Maca-GO as a reliable alternative to HRT program.
  • MEISSNER, H. O.; et al. Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium Peruvianum Chacon): (III) Clinical Responses of Early-Postmenopausal Women to Maca in Double Blind, Randomized, Placebo-controlled, Crossover Configuration, Outpatient Study. International journal of biomedical science: IJBS, 2006, 2.4: 375. PMID:23675006
• The properties of Hypericum Perforatum against Menopause syndrome:
  • EATEMADNIA, Alieh; et al. The Effect of Hypericum Perforatum on Postmenopausal Symptoms and Depression: A Randomized Controlled Trial. Complementary therapies in medicine, 2019, 45: 109-113. PMID:31331546
    Conclusion: Treatment with Hypericum perforatum is an efficient way of reducing hot flashes, menopausal symptoms, and depression in postmenopausal women.
• The properties of Tribulus Terrestris against Menopause syndrome:
  • VALE, Fabiene Bernardes Castro; et al. Efficacy of Tribulus Terrestris for the Treatment of Premenopausal Women With Hypoactive Sexual Desire Disorder: A Randomized Double-Blinded, Placebo-Controlled Trial. Gynecological Endocrinology, 2018, 34.5: 442-445. PMID:29172782
  • DE SOUZA, Karla Zanolla Dias; VALE, Fabiene Bernardes Castro; GEBER, Selmo. Efficacy of Tribulus Terrestris for the Treatment of Hypoactive Sexual Desire Disorder in Postmenopausal Women: A Randomized, Double-Blinded, Placebo-Controlled Trial. Menopause, 2016, 23.11: 1252-1256. PMID:27760089
    Conclusions: Tribulus terrestris might be a safe alternative for the treatment of hypoactive sexual desire disorder in postmenopausal women, because it was effective in reducing symptoms with few side effects. Its probable mechanism of action involves an increase in the serum levels of free and bioavailable testosterone.
  • POSTIGO, Sóstenes; et al. Assessment of the Effects of Tribulus Terrestris on Sexual Function of Menopausal Women. Revista Brasileira de Ginecologia e Obstetrícia/RBGO Gynecology and Obstetrics, 2016, 38.03: 140-146. PMID:26902700
    Conclusions: After 90 days of treatment, at the doses used, we found Tribulus terrestris to be effective in treating sexual problems among menopausal women.