Varicorin

This description has been derived from the manufacturer’s / distributor’s website.

Varicorin is the ideal solution for people suffering from varicose veins, spider veins or swollen legs. The formula developed on the basis of the most effective ingredients available on the market allows the supplement to effectively support venous problems.

The secret to Varicorin’s effectiveness is its advanced composition, which thanks to the synergy effect affects many aspects of blood vessels health. The ingredients have been selected to to fight the most common ailments affecting persons with impaired circulation or those suffering from heavy legs and swelling.

Effectively fights varicose veins.
Reduces the feeling of heavy legs.
Reduces swelling and supports circulation.
Increases the excretion of excess water.
Supports the health of blood vessel walls.

Clinical studies clearly indicate that the ingredients contained in the Varicorin food supplement support the appearance of the legs and the health of blood vessels and act as an auxiliary in the treatment of: varicose veins, leg swelling, spider veins, hemorrhoids, feelings of heavy legs.

Varicorin – Ingredients

Venocin® (Horse Chestnut Seed Extract / 20% Aescin)
- Horse Chestnut (Aesculus Hippocastanum)Species: Aesculus Hippocastanum,
  Family: Sapindaceae,
  European Medicines Agency: EMA: Hippocastani Semen,
  European Medicines Agency: EMA: Hippocastani Cortex,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH393870,
  References:
  Varicose Veins: MACKAY, Douglas Hemorrhoids and varicose veins: a review of treatment options. Alternative medicine review, 2001, 6.2: 126-126. PMID:11302778, LANDER, E. Aesculus and Hamamelis in therapy of venous circulatory disorders. Medizinische Klinik, 1953, 48.2: 48. PMID:13119242.
- Aescin (C₅₅H₈₆O₂₄)
  Aescin: Aescin, Escin, Escin Ib, EscinI B, Escine Ib, beta-Escin,
  PubChem CID: 6476031,
  Chemical Abstracts Service: CAS: 26339-90-2,
  ChemIDplus: 26339-90-2,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS38EA50,
  References:
  Varicose Veins: SCHRADER, E.; et al. Vergleichende Untersuchung zur Bioverfügbarkeit von β-Aescin nach oraler Einmalverabreichung zweier Rosskastaniensamenextrakt enthaltender, galenisch unterschiedlicher Darreichungsformen. Pharmazie, 1995, 50.9: 623-627., ANNONI, F.; MAURI, A.; MARINCOLA, F.; RESELE, L. F. Venotonic activity of escin on the human saphenous vein. Arzneimittel-Forschung, 1979, 29.4: 672-675. PMID:582766.
Centellin® (Asiatic Pennywort (Gotu Kola) Leaf Extract / 8% Triterpenes)
- Gotu Kola (Centella Asiatica)Species: Centella Asiatica,
  Family: Apiaceae Mackinlayaceae,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH4FA6A0,
  References:
  Varicose Veins: ARPAIA, M. R.; FERRONE, R.; AMITRANO, M.; NAPPO, C.; LEONARDO, G.; DEL GUERCIO, R. Effects of Centella asiatica extract on mucopolysaccharide metabolism in subjects with varicose veins. International journal of clinical pharmacology research, 1990, 10.4: 229-233. PMID:2150405, INCANDELA, L.; BELCARO, G.; NICOLAIDES, A. N.; CESARONE, M. R.; DE SANCTIS, M. T.; CORSI, M.; BAVERA, P.; IPPOLITO, E.; GRIFFIN, M.; GEROULAKOS, G.; SABETAI, M.; RAMASWAMI, G.; VELLER, M. Modification of the Echogenicity of Femoral Plaques after Treatment with Total Triterpenic Fraction of Centella asiatica: A Prospective, Randomized, Placebo-Controlled Trial. Angiology, 2001, 52.2_suppl: S69-S73. PMID:11666127,
  Cardiovascular Support: RAZALI, Nur Nadia Mohd; NG, Chin Theng; FONG, Lai Yen Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review. Planta medica, 2019, 85.16: 1203-1215. PMID:31539918.
- Triterpenes (C₃₀H₄₈)
  Triterpenes: Triterpenes, Triterpene, The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS391160.
  - Madecassol (C₄₈H₇₈O₁₉)
    Madecassol: Madecassol, Asiaticoside, Centelase, Blastostimulina,
    PubChem CID: 11954171,
    Chemical Abstracts Service: CAS: 16830-15-2,
    ChemIDplus: 16830-15-2,
    FDA Substance Registration System – Unique Ingredient Identifier: UNII: PKO39VY215,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISEDBB60.
  - Brahmoside
    Brahmoside: Brahmoside, Brahminoside, PubChem CID: 395762, The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISED9450.
  - Asiatic Acid (C₃₀H₄₈O₅)
    Asiatic Acid: Asiatic Acid, Asiantic Acid, Dammarolic Acid,
    PubChem CID: 119034,
    Chemical Abstracts Service: CAS: 464-92-6,
    ChemIDplus: 464-92-6,
    FDA Substance Registration System – Unique Ingredient Identifier: UNII: 9PA5A687X5,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISED6D40.
  - Madecassic Acid (C₃₀H₄₈O₆)
    Madecassic Acid: Madecassic Acid, Brahmic Acid, 6Beta-Hydroxyasiatic Acid,
    PubChem CID: 73412,
    Chemical Abstracts Service: CAS: 18449-41-7,
    ChemIDplus: 18449-41-7,
    FDA Substance Registration System – Unique Ingredient Identifier: UNII: M7O1N24J82,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISED4630.
Bitter Orange Peel Extract (90% Hesperidin)
- Bitter Orange (Citrus Aurantium)Species: Citrus Aurantium,
  Family: Rutaceae,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2932E0,
  References:
  Varicose Veins: ION, Rodica-Mariana; et al. FLAVONOIDS, POLIFENOLS CONTENT AND ANTIOXIDANT ACTIVITY OF CITRUS FRUITS EXTRACTS. Researchgate, 2015..
- Hesperidin (C₂₈H₃₄O₁₅)
  Hesperidin: Hesperidin, Hesperidine, Cirantin, Hesperidoside, Hesper Bitabs, Hesperetin-Rutinosid,
  PubChem CID: 10621,
  Chemical Abstracts Service: CAS: 520-26-3,
  ChemIDplus: 520-26-3,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS2D78A0,
  References:
  Varicose Veins: JAWIEN, Arkadiusz.; BOUSKELA, E.; ALLAERT, F. A.; NICOLAïDES, A. N. The place of Ruscus extract, hesperidin methyl chalcone, and vitamin C in the management of chronic venous disease. International angiology: a journal of the International Union of Angiology, 2017, 36.1: 31-41. PMID:28124877, ALLAERT, Francois-Andre Combination of Ruscus aculeatus extract, hesperidin methyl chalcone and ascorbic acid: a comprehensive review of their pharmacological and clinical effects and of the pathophysiology of chronic venous disease. International angiology: a journal of the International Union of Angiology, 2016, 35.2: 111-116. PMID:26928296.
Butcher’s Broom Root Extract (Ruscus Aculeatus)Species: Ruscus Aculeatus,
Family: Asparagaceae,
European Medicines Agency: EMA: Rusci Aculeati Rhizoma,
The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH3763B0,
References:
Varicose Veins: CAPPELLI, R.; NICORA, M.; DI PERRI, T. Use of extract of Ruscus aculeatus in venous disease in the lower limbs. Drugs under experimental and clinical research, 1988, 14.4: 277-283. PMID:3048951, JAWIEN, Arkadiusz.; BOUSKELA, E.; ALLAERT, F. A.; NICOLAïDES, A. N. The place of Ruscus extract, hesperidin methyl chalcone, and vitamin C in the management of chronic venous disease. International angiology: a journal of the International Union of Angiology, 2017, 36.1: 31-41. PMID:28124877.
Buckwheat Seed Extract (70% Vitamin C)
- Buckwheat (Fagopyrum Esculentum)Species: Fagopyrum Esculentum,
  Family: Polygonaceae,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH378AC0,
  References:
  Varicose Veins: IHME, N.; KIESEWETTER, H.; JUNG, F.; HOFFMANN, K. H.; BIRK, A.; MüLLER, A.; GRüTZNER, K. I. Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled clinical trial. European Journal of Clinical Pharmacology, 1996, 50.6: 443-447. PMID:8858269.
- Vitamin C (Ascorbic Acid) (C₆H₈O₆)
  Vitamin C deficiency is associated with a higher risk of mortality from CVD and that vitamin C may slightly improve endothelial function and lipid profiles in some groups, especially those with low plasma vitamin C levels.
  Vitamin C (Ascorbic Acid): Ascorbic Acid, L-Ascorbic Acid, L(+)-Ascorbic Acid, Vitamin C,
  PubChem CID: 54670067,
  Chemical Abstracts Service: CAS: 50-81-7,
  ChemIDplus: 50-81-7,
  WHO Anatomical Therapeutic Chemical Classification System: ATC code: A11GA01,
  FDA Substance Registration System – Unique Ingredient Identifier: UNII: PQ6CK8PD0R,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS2D5190,
  References:
  Cardiovascular Support: ELLULU, Mohammed S. Obesity, Cardiovascular Disease, and Role of Vitamin C on Inflammation: A Review of Facts and Underlying Mechanisms. Inflammopharmacology, 2017, 25.3: 313-328. PMID:28168552, MOSER, Melissa A.; CHUN, Ock K. Vitamin C and Heart Health: A Review Based on Findings From Epidemiologic Studies. International journal of molecular sciences, 2016, 17.8: 1328. PMID:27529239,
  Varicose Veins: ALLAERT, Francois-Andre Combination of Ruscus aculeatus extract, hesperidin methyl chalcone and ascorbic acid: a comprehensive review of their pharmacological and clinical effects and of the pathophysiology of chronic venous disease. International angiology: a journal of the International Union of Angiology, 2016, 35.2: 111-116. PMID:26928296.
Common Grape Vine Fruit Extract (2% Resveratrol)
- Common Grape Vine (Vitis Vinifera)Species: Vitis Vinifera,
  Family: Vitaceae,
  European Medicines Agency: EMA: Vitis Viniferae Folium,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2D9FB0,
  References:
  Varicose Veins: DRAIJER, Richard; DE GRAAF, Y.; SLETTENAAR, M.; DE GROOT, E.; WRIGHT, C. I. Consumption of a polyphenol-rich grape-wine extract lowers ambulatory blood pressure in mildly hypertensive subjects. Nutrients, 2015, 7.5: 3138-3153. PMID:25942487, LI, Shao-Hua; ZHAO, P.; TIAN, H. B.; CHEN, L. H.; CUI, L. Q. Effect of grape polyphenols on blood pressure: a meta-analysis of randomized controlled trials. PLoS One, 2015, 10.9: e0137665. PMID:26375022,
  Cardiovascular Support: KIM, Jong-Kyung; et al. Grape Seed Extract Supplementation Attenuates the Blood Pressure Response to Exercise in Prehypertensive Men. Journal of medicinal food, 2018, 21.5: 445-453. PMID:29683391, FERINGA, Harm H. H.; et al. The Effect of Grape Seed Extract on Cardiovascular Risk Markers: A Meta-Analysis of Randomized Controlled Trials. Journal of the American Dietetic Association, 2011, 111.8: 1173-1181. PMID:21802563.
- Resveratrol (C₁₄H₁₂O₃)
  Recent experimental studies have found that resveratrol offers a variety of benefits that include both anticarcinogenic and anti-inflammatory effects in addition to the ability to reverse obesity, attenuate hyperglycemia and hyperinsulinemia, protect heart and endothelial function, and increase the life span.
  Resveratrol: Resveratrol, Trans-Resveratrol, Resvida,
  PubChem CID: 445154,
  Chemical Abstracts Service: CAS: 501-36-0,
  ChemIDplus: 501-36-0,
  FDA Substance Registration System – Unique Ingredient Identifier: UNII: Q369O8926L,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS37B1D0,
  References:
  Varicose Veins: LI, Huige; XIA, N.; HASSELWANDER, S.; DAIBER, A. Resveratrol and Vascular Function. International journal of molecular sciences, 2019, 20.9: 2155. PMID:31052341,
  Cardiovascular Support: CHO, Sanghyun; et al. Cardiovascular Protective Effects and Clinical Applications of Resveratrol. Journal of medicinal food, 2017, 20.4: 323-334. PMID:28346848, WICIńSKI, Michał Beneficial Effects of Resveratrol Administration-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions. Nutrients, 2018, 10.11: 1813. PMID:30469326.
American Witch Hazel Root Extract (Hamamelis Virginiana)Species: Hamamelis Virginiana,
Family: Hamamelidaceae,
European Medicines Agency: EMA: Hamamelidis Folium,
European Medicines Agency: EMA: Hamamelidis Folium Et Cortex Aut Ramunculus Destillatum,
European Medicines Agency: EMA: Hamamelidis Cortex,
The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2DC6C0,
References:
Varicose Veins: LANDER, E. Aesculus and Hamamelis in therapy of venous circulatory disorders. Medizinische Klinik, 1953, 48.2: 48. PMID:13119242.
Nettle Leaf Extract
- Nettle (Urtica Dioica)Species: Urtica Dioica,
  Family: Urticaceae,
  European Medicines Agency: EMA: Urticae Radix,
  European Medicines Agency: EMA: Urticae Folium,
  European Medicines Agency: EMA: Urticae Herba,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH27D350.
BioPerine® (Black Pepper Fruit Extract / 95% Piperine)
- Black Pepper (Piper Nigrum)Species: Piper Nigrum,
  Family: Piperaceae,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2CB550,
  References:
  Varicose Veins: NEWERLI-GUZ, Joanna; ŚMIECHOWSKA, Maria Assessment of the contents of piperine in black pepper berries Piper nigrum L. Bromatologia i Chemia Toksykologiczna, 2009, XLII: 827–830..
- Piperine (C₁₇H₁₉NO₃)
  Piperine: Piperine, Bioperine, Piperin, 1-Piperoylpiperidine, Piperoylpiperidine, 1-Piperylpiperidine,
  PubChem CID: 638024,
  Chemical Abstracts Service: CAS: 94-62-2,
  ChemIDplus: 94-62-2,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS395F80,
  References:
  Varicose Veins: TAQVI, Syed Intasar Husain; SHAH, Abdul Jabbar; GILANI, Anwarul Hassan Blood pressure lowering and vasomodulator effects of piperine. Journal of cardiovascular pharmacology, 2008, 52.5: 452-458. PMID:19033825.

Recommended intake of this supplement: 2 capsule, daily (adults).

Additional information

Manufacturer:	NuviaLab

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TestoGen

The Varicorin dietary supplement is available in Israel and many others countries around the world. In Israel this supplement contains: Aescin, Asiatic Acid, BioPerine®, Bitter Orange, Black Pepper, Brahmoside, Buckwheat, Butcher’s Broom, Centellin®, Common Grape Vine, Gotu Kola, Hesperidin, Horse Chestnut, Madecassic Acid, Madecassol, Nettle, Piperine, Resveratrol, Terpenes, Triterpenes, Venocin®, Vitamin C and Witch Hazel in its composition.

Detailed descriptions of the ingredients included in the Varicorin dietary supplement:

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