Li Shao-Hua, Zhao P., Tian H. B., Chen L. H., Cui L. Q.
PLoS One, 2015
Abstract
Background
The effect of grape polyphenols on blood pressure remains unclear, which we aimed to address via a meta-analysis study.
Methods
We conducted study trial searches in PubMed, Embase, and the Cochrane Library databases. Summary estimates of weighted mean differences and 95% confidence intervals were obtained by using fixed-effects models. Subgroup analyses were performed to identify the source of heterogeneity. The protocol details of our meta-analysis have been submitted to the international database of prospectively registered systematic reviews (registration number CRD42015019196).
Results
Ten studies were included in the present meta-analysis. Our results showed daily grape polyphenol intake could significantly reduce systolic blood pressure by 1.48 mmHg when compared to control subjects (12 comparisons; -1.48 [-2.79 to -0.16] mmHg; P = 0.03). Subgroup analyses indicated larger reduction was identified in the intake of low-dose of grape polyphenols (< 733 mg/day, median level of the included studies) or patients with metabolic syndrome. Contrarily, diastolic blood pressure was not significantly decreased in the grape polyphenols group as compared to controls. No significant heterogeneity or publication bias was detected in the meta-analysis of either systolic or diastolic blood pressure.
Conclusions
Daily grape polyphenol intake can significantly reduce the systolic blood pressure in humans, although the reduction is modest when compared with anti-hypertensive medications. Larger, better designed trials, that specifically include hypertensive subjects, are required to verify our results in the future.
| PMID: | 26375022 |
|---|---|
| Category: | Varicose Veins |
The best supplements with Vitis Vinifera in Varicose Veins category:
- Varicorin - Varicorin is the ideal solution for people suffering from varicose veins, spider veins or swollen legs. It contains among others: Vitis Vinifera.
Articles similar to "Effect of grape polyphenols on blood pressure: a meta-analysis of randomized controlled trials."
- The significance of Vitis Vinifera for Varicose Veins: Consumption of a polyphenol-rich grape-wine extract lowers ambulatory blood pressure in mildly hypertensive subjects. (Polyphenols in grape and wine have been suggested to contribute to the cardiovascular health benefits of the Mediterranean lifestyle...)