Varicorin

Varicorin – Ingrediënten

• Venocin® (Horse Chestnut Seed Extract / 20% Aescin)
  • Horse Chestnut (Aesculus Hippocastanum)Species: Aesculus Hippocastanum,
    Family: Sapindaceae,
    European Medicines Agency: EMA: Hippocastani Semen,
    European Medicines Agency: EMA: Hippocastani Cortex,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH393870,
    References:
    Varicose Veins: MACKAY, Douglas Hemorrhoids and varicose veins: a review of treatment options. Alternative medicine review, 2001, 6.2: 126-126. PMID:11302778, LANDER, E. Aesculus and Hamamelis in therapy of venous circulatory disorders. Medizinische Klinik, 1953, 48.2: 48. PMID:13119242.
    
    
  • Aescin (C₅₅H₈₆O₂₄)
    Aescin: Aescin, Escin, Escin Ib, EscinI B, Escine Ib, beta-Escin,
    PubChem CID: 6476031,
    Chemical Abstracts Service: CAS: 26339-90-2,
    ChemIDplus: 26339-90-2,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS38EA50,
    References:
    Varicose Veins: SCHRADER, E.; et al. Vergleichende Untersuchung zur Bioverfügbarkeit von β-Aescin nach oraler Einmalverabreichung zweier Rosskastaniensamenextrakt enthaltender, galenisch unterschiedlicher Darreichungsformen. Pharmazie, 1995, 50.9: 623-627., ANNONI, F.; MAURI, A.; MARINCOLA, F.; RESELE, L. F. Venotonic activity of escin on the human saphenous vein. Arzneimittel-Forschung, 1979, 29.4: 672-675. PMID:582766.
    
• Centellin® (Asiatic Pennywort (Gotu Kola) Leaf Extract / 8% Triterpenes)
  • Gotu Kola (Centella Asiatica)Species: Centella Asiatica,
    Family: Apiaceae Mackinlayaceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH4FA6A0,
    References:
    Varicose Veins: ARPAIA, M. R.; FERRONE, R.; AMITRANO, M.; NAPPO, C.; LEONARDO, G.; DEL GUERCIO, R. Effects of Centella asiatica extract on mucopolysaccharide metabolism in subjects with varicose veins. International journal of clinical pharmacology research, 1990, 10.4: 229-233. PMID:2150405, INCANDELA, L.; BELCARO, G.; NICOLAIDES, A. N.; CESARONE, M. R.; DE SANCTIS, M. T.; CORSI, M.; BAVERA, P.; IPPOLITO, E.; GRIFFIN, M.; GEROULAKOS, G.; SABETAI, M.; RAMASWAMI, G.; VELLER, M. Modification of the Echogenicity of Femoral Plaques after Treatment with Total Triterpenic Fraction of Centella asiatica: A Prospective, Randomized, Placebo-Controlled Trial. Angiology, 2001, 52.2_suppl: S69-S73. PMID:11666127,
    Cardiovascular Support: RAZALI, Nur Nadia Mohd; NG, Chin Theng; FONG, Lai Yen Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review. Planta medica, 2019, 85.16: 1203-1215. PMID:31539918.
    
    
  • Triterpenes (C₃₀H₄₈)
    Triterpenes: Triterpenes, Triterpene, The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS391160.
    
    • Madecassol (C₄₈H₇₈O₁₉)
      Madecassol: Madecassol, Asiaticoside, Centelase, Blastostimulina,
      PubChem CID: 11954171,
      Chemical Abstracts Service: CAS: 16830-15-2,
      ChemIDplus: 16830-15-2,
      FDA Substance Registration System – Unique Ingredient Identifier: UNII: PKO39VY215,
      The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISEDBB60.
      
    • Brahmoside
      Brahmoside: Brahmoside, Brahminoside, PubChem CID: 395762, The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISED9450.
      
    • Asiatic Acid (C₃₀H₄₈O₅)
      Asiatic Acid: Asiatic Acid, Asiantic Acid, Dammarolic Acid,
      PubChem CID: 119034,
      Chemical Abstracts Service: CAS: 464-92-6,
      ChemIDplus: 464-92-6,
      FDA Substance Registration System – Unique Ingredient Identifier: UNII: 9PA5A687X5,
      The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISED6D40.
      
    • Madecassic Acid (C₃₀H₄₈O₆)
      Madecassic Acid: Madecassic Acid, Brahmic Acid, 6Beta-Hydroxyasiatic Acid,
      PubChem CID: 73412,
      Chemical Abstracts Service: CAS: 18449-41-7,
      ChemIDplus: 18449-41-7,
      FDA Substance Registration System – Unique Ingredient Identifier: UNII: M7O1N24J82,
      The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISED4630.
      
• Bitter Orange Peel Extract (90% Hesperidin)
  • Bitter sinaasappel extract (Citrus Aurantium)Species: Citrus Aurantium,
    Family: Rutaceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2932E0,
    References:
    Varicose Veins: ION, Rodica-Mariana; et al. FLAVONOIDS, POLIFENOLS CONTENT AND ANTIOXIDANT ACTIVITY OF CITRUS FRUITS EXTRACTS. Researchgate, 2015..
    
    
  • Hesperidine (C₂₈H₃₄O₁₅)
    Hesperidine: Hesperidin, Cirantin, Hesperidoside, Hesper Bitabs, Hesperetin-Rutinosid,
    PubChem CID: 10621,
    Chemical Abstracts Service: CAS: 520-26-3,
    ChemIDplus: 520-26-3,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS2D78A0,
    References:
    Varicose Veins: JAWIEN, Arkadiusz.; BOUSKELA, E.; ALLAERT, F. A.; NICOLAïDES, A. N. The place of Ruscus extract, hesperidin methyl chalcone, and vitamin C in the management of chronic venous disease. International angiology: a journal of the International Union of Angiology, 2017, 36.1: 31-41. PMID:28124877, ALLAERT, Francois-Andre Combination of Ruscus aculeatus extract, hesperidin methyl chalcone and ascorbic acid: a comprehensive review of their pharmacological and clinical effects and of the pathophysiology of chronic venous disease. International angiology: a journal of the International Union of Angiology, 2016, 35.2: 111-116. PMID:26928296.
    
• Butcher’s Broom Root Extract (Ruscus Aculeatus)Species: Ruscus Aculeatus,
  Family: Asparagaceae,
  European Medicines Agency: EMA: Rusci Aculeati Rhizoma,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH3763B0,
  References:
  Varicose Veins: CAPPELLI, R.; NICORA, M.; DI PERRI, T. Use of extract of Ruscus aculeatus in venous disease in the lower limbs. Drugs under experimental and clinical research, 1988, 14.4: 277-283. PMID:3048951, JAWIEN, Arkadiusz.; BOUSKELA, E.; ALLAERT, F. A.; NICOLAïDES, A. N. The place of Ruscus extract, hesperidin methyl chalcone, and vitamin C in the management of chronic venous disease. International angiology: a journal of the International Union of Angiology, 2017, 36.1: 31-41. PMID:28124877.
  
  
• Buckwheat Seed Extract (70% Vitamin C)
  • Buckwheat (Fagopyrum Esculentum)Species: Fagopyrum Esculentum,
    Family: Polygonaceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH378AC0,
    References:
    Varicose Veins: IHME, N.; KIESEWETTER, H.; JUNG, F.; HOFFMANN, K. H.; BIRK, A.; MüLLER, A.; GRüTZNER, K. I. Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled clinical trial. European Journal of Clinical Pharmacology, 1996, 50.6: 443-447. PMID:8858269.
    
    
  • Vitamine C (C₆H₈O₆)
    Vitamin C deficiency is associated with a higher risk of mortality from CVD and that vitamin C may slightly improve endothelial function and lipid profiles in some groups, especially those with low plasma vitamin C levels.
    Vitamine C: Ascorbic Acid, L-Ascorbic Acid, L(+)-Ascorbic Acid, Vitamin C,
    PubChem CID: 54670067,
    Chemical Abstracts Service: CAS: 50-81-7,
    ChemIDplus: 50-81-7,
    WHO Anatomical Therapeutic Chemical Classification System: ATC code: A11GA01,
    FDA Substance Registration System – Unique Ingredient Identifier: UNII: PQ6CK8PD0R,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS2D5190,
    References:
    Cardiovascular Support: ELLULU, Mohammed S. Obesity, Cardiovascular Disease, and Role of Vitamin C on Inflammation: A Review of Facts and Underlying Mechanisms. Inflammopharmacology, 2017, 25.3: 313-328. PMID:28168552, MOSER, Melissa A.; CHUN, Ock K. Vitamin C and Heart Health: A Review Based on Findings From Epidemiologic Studies. International journal of molecular sciences, 2016, 17.8: 1328. PMID:27529239,
    Varicose Veins: ALLAERT, Francois-Andre Combination of Ruscus aculeatus extract, hesperidin methyl chalcone and ascorbic acid: a comprehensive review of their pharmacological and clinical effects and of the pathophysiology of chronic venous disease. International angiology: a journal of the International Union of Angiology, 2016, 35.2: 111-116. PMID:26928296.
    
• Common Grape Vine Fruit Extract (2% Resveratrol)
  • Common Grape Vine (Vitis Vinifera)Species: Vitis Vinifera,
    Family: Vitaceae,
    European Medicines Agency: EMA: Vitis Viniferae Folium,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2D9FB0,
    References:
    Varicose Veins: DRAIJER, Richard; DE GRAAF, Y.; SLETTENAAR, M.; DE GROOT, E.; WRIGHT, C. I. Consumption of a polyphenol-rich grape-wine extract lowers ambulatory blood pressure in mildly hypertensive subjects. Nutrients, 2015, 7.5: 3138-3153. PMID:25942487, LI, Shao-Hua; ZHAO, P.; TIAN, H. B.; CHEN, L. H.; CUI, L. Q. Effect of grape polyphenols on blood pressure: a meta-analysis of randomized controlled trials. PLoS One, 2015, 10.9: e0137665. PMID:26375022,
    Cardiovascular Support: KIM, Jong-Kyung; et al. Grape Seed Extract Supplementation Attenuates the Blood Pressure Response to Exercise in Prehypertensive Men. Journal of medicinal food, 2018, 21.5: 445-453. PMID:29683391, FERINGA, Harm H. H.; et al. The Effect of Grape Seed Extract on Cardiovascular Risk Markers: A Meta-Analysis of Randomized Controlled Trials. Journal of the American Dietetic Association, 2011, 111.8: 1173-1181. PMID:21802563.
    
    
  • Resveratrol (C₁₄H₁₂O₃)
    Recent experimental studies have found that resveratrol offers a variety of benefits that include both anticarcinogenic and anti-inflammatory effects in addition to the ability to reverse obesity, attenuate hyperglycemia and hyperinsulinemia, protect heart and endothelial function, and increase the life span.
    Resveratrol: Resveratrol, Trans-Resveratrol, Resvida,
    PubChem CID: 445154,
    Chemical Abstracts Service: CAS: 501-36-0,
    ChemIDplus: 501-36-0,
    FDA Substance Registration System – Unique Ingredient Identifier: UNII: Q369O8926L,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS37B1D0,
    References:
    Varicose Veins: LI, Huige; XIA, N.; HASSELWANDER, S.; DAIBER, A. Resveratrol and Vascular Function. International journal of molecular sciences, 2019, 20.9: 2155. PMID:31052341,
    Cardiovascular Support: CHO, Sanghyun; et al. Cardiovascular Protective Effects and Clinical Applications of Resveratrol. Journal of medicinal food, 2017, 20.4: 323-334. PMID:28346848, WICIńSKI, Michał Beneficial Effects of Resveratrol Administration-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions. Nutrients, 2018, 10.11: 1813. PMID:30469326.
    
• American Witch Hazel Root Extract (Hamamelis Virginiana)Species: Hamamelis Virginiana,
  Family: Hamamelidaceae,
  European Medicines Agency: EMA: Hamamelidis Folium,
  European Medicines Agency: EMA: Hamamelidis Folium Et Cortex Aut Ramunculus Destillatum,
  European Medicines Agency: EMA: Hamamelidis Cortex,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2DC6C0,
  References:
  Varicose Veins: LANDER, E. Aesculus and Hamamelis in therapy of venous circulatory disorders. Medizinische Klinik, 1953, 48.2: 48. PMID:13119242.
  
  
• Nettle Leaf Extract
  • Brandnetel (Urtica Dioica)Species: Urtica Dioica,
    Family: Urticaceae,
    European Medicines Agency: EMA: Urticae Radix,
    European Medicines Agency: EMA: Urticae Folium,
    European Medicines Agency: EMA: Urticae Herba,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH27D350.
    
    
• BioPerine® (Black Pepper Fruit Extract / 95% Piperine)
  • Black Pepper (Piper Nigrum)Species: Piper Nigrum,
    Family: Piperaceae,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH2CB550,
    References:
    Varicose Veins: NEWERLI-GUZ, Joanna; ŚMIECHOWSKA, Maria Assessment of the contents of piperine in black pepper berries Piper nigrum L. Bromatologia i Chemia Toksykologiczna, 2009, XLII: 827–830..
    
    
  • Piperine (C₁₇H₁₉NO₃)
    Piperine: Piperine, Bioperine, Piperin, 1-Piperoylpiperidine, Piperoylpiperidine, 1-Piperylpiperidine,
    PubChem CID: 638024,
    Chemical Abstracts Service: CAS: 94-62-2,
    ChemIDplus: 94-62-2,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS395F80,
    References:
    Varicose Veins: TAQVI, Syed Intasar Husain; SHAH, Abdul Jabbar; GILANI, Anwarul Hassan Blood pressure lowering and vasomodulator effects of piperine. Journal of cardiovascular pharmacology, 2008, 52.5: 452-458. PMID:19033825.
    

  
  

Recommended intake of this supplement: 2 capsule, daily (adults).