This description has been derived from the manufacturer’s / distributor’s website.
NOW DHA-500 has twice the DHA (500 mg per softgel) as in our regular strength product (250 mg per softgel). The natural fish oil concentrate used in this softgel is manufactured under strict quality control standards. It is tested to be free of potentially harmful levels of contaminants (i.e. mercury, heavy metals, PCB’s, dioxins, and other contaminants). Those who experience nausea or reflux from other fish oils should find this enteric-coated, odor-controlled softgel easier to tolerate.
DHA-500/EPA-250, Double Strength, 180 Softgels (Now Foods) – Ingredients
- Fish Oil
Fish oil is recommended for the management of hypertriglyceridemia and to prevent secondary cardiovascular disorders. Fish oil is a major source of ω-3-polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Clinical studies suggest that fish oil not only prevents the incidence of detrimental cardiovascular events, but also lowers the cardiovascular mortality rate.
Fish Oil: Fish Oil,
The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISC99190,
References:
Cardiovascular Support: BALAKUMAR, Pitchai; TANEJA, Gaurav Fish Oil and Vascular Endothelial Protection: Bench to Bedside. Free Radical Biology and Medicine, 2012, 53.2: 271-279. PMID:22584102,
Brain / Mental Clarity: BOESPFLUG, E. L.; et al. Fish Oil Supplementation Increases Event-Related Posterior Cingulate Activation in Older Adults With Subjective Memory Impairment. The journal of nutrition, health & aging, 2016, 20.2: 161-169. PMID:26812512, FORTES CAVALCANTI DE MACêDO, Patrícia; et al. Fish Oil and Treadmill Exercise Have Age-Dependent Effects on Episodic Memory and Oxidative State of the Hippocampus. Applied Physiology, Nutrition, and Metabolism, 2017, 42.5: 503-510. PMID:28177723.
- Omega-3 Acids
The omega-3 fatty acids are essential dietary nutrients and one of their important roles is providing the fatty acid with 22 carbons and 6 double bonds known as docosahexaenoic acid (DHA) for nervous tissue growth and function. Inadequate intakes of omega-3 fatty acids decrease DHA and increase omega-6 fatty acids in the brain. Human studies suggest that an adequate dietary intake of ω-3 PUFA can slow the age-related cognitive decline and may also protect against the risk of senile dementia. Omega-3 Fatty acids benefit multiple risk factors including blood pressure, blood vessel function, heart function and blood lipids, and they have antithrombotic, anti-inflammatory and anti-oxidative actions. Supplementation with Omega-3 (ω3) fatty acids is recommended in individuals with elevated blood triglyceride levels and patients with coronary heart disease.
Omega-3 Acids: Omega-3 Acids, The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS317040, References: Brain / Mental Clarity: INNIS, Sheila M. Dietary Omega 3 Fatty Acids and the Developing Brain. Brain research, 2008, 1237: 35-43. PMID:18789910, LAYé, Sophie; et al. Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology. Pharmacological Reviews, 2018, 70.1: 12-38. PMID:29217656, Cardiovascular Support: MORI, Trevor A. Marine OMEGA-3 Fatty Acids in the Prevention of Cardiovascular Disease. Fitoterapia, 2017, 123: 51-58. PMID:28964873, JAIN, A. P.; AGGARWAL, K. K.; ZHANG, P. Y. Omega-3 Fatty Acids and Cardiovascular Disease. Eur Rev Med Pharmacol Sci, 2015, 19.3: 441-5. PMID:25720716.
- Docosahexaenoic Acid (C22H32O2)
Docosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in phospholipids in the brain and retina, is known to play multi-functional roles in brain health and diseases. The inclusion of plentiful DHA in the diet improves learning ability, whereas deficiencies of DHA are associated with deficits in learning. DHA is taken up by the brain in preference to other fatty acids. DHA inhibits the development of inflammation in endothelial cells, alters the function and regulation of vascular biomarkers, and reduces cardiovascular risk. Docosahexaenoic Acid: Docosahexaenoic Acid, DHA, Doconexent, Cervonic acid,
PubChem CID: 445580,
Chemical Abstracts Service: CAS: 6217-54-5,
ChemIDplus: 6217-54-5,
FDA Substance Registration System – Unique Ingredient Identifier: UNII: ZAD9OKH9JC,
The Best Supplements – Unique Ingredient Identifier: TBSI ID: IS3567E0,
References:
Brain / Mental Clarity: SUN, Grace Y.; et al. Docosahexaenoic Acid (DHA): An Essential Nutrient and a Nutraceutical for Brain Health and Diseases. Prostaglandins, Leukotrienes and Essential Fatty Acids, 2018, 136: 3-13. PMID:28314621, HORROCKS, Lloyd A.; YEO, Young K. Health Benefits of Docosahexaenoic Acid (DHA). Pharmacological research, 1999, 40.3: 211-225. PMID:10479465,
Cardiovascular Support: YAMAGATA, Kazuo Docosahexaenoic Acid Regulates Vascular Endothelial Cell Function and Prevents Cardiovascular Disease. Lipids in health and disease, 2017, 16.1: 118. PMID:28619112.
- Eicosapentaenoic Acid (C20H30O2)
The omega-3 fatty acid eicosapentaenoic acid (EPA) has multiple actions potentially conferring cardiovascular benefit, including lowering serum triglyceride (TG) and non-high-density lipoprotein cholesterol (non-HDL-C) levels and potentially reducing key steps in atherogenesis. Eicosapentaenoic Acid: Eicosapentaenoic Acid, EPA, Timnodonic Acid, Icosapent,
PubChem CID: 446284,
Chemical Abstracts Service: CAS: 10417-94-4,
ChemIDplus: 10417-94-4,
FDA Substance Registration System – Unique Ingredient Identifier: UNII: AAN7QOV9EA,
The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISBF7F70,
References:
Cardiovascular Support: GOLZARI, Mohammad Hassan; et al. Effect of Eicosapentaenoic Acid (EPA) Supplementation on Cardiovascular Markers in Patients With Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2018, 12.3: 411-415. PMID:29588138, BRINTON, Eliot A.; MASON, R. Preston Prescription omega-3 Fatty Acid Products Containing Highly Purified Eicosapentaenoic Acid (EPA). Lipids in health and disease, 2017, 16.1: 23. PMID:28137294,
Brain / Mental Clarity: BAZINET, Richard P.; et al. Brain Eicosapentaenoic Acid Metabolism as a Lead for Novel Therapeutics in Major Depression. Brain, behavior, and immunity, 2019, Jul 3: . PMID:31278982, CEDERHOLM, Tommy; SALEM JR, Norman; PALMBLAD, Jan ω-3 Fatty Acids in the Prevention of Cognitive Decline in Humans. Advances in nutrition, 2013, 4.6: 672-676. PMID:24228198. - Eicosapentaenoic Acid (C20H30O2)
- Docosahexaenoic Acid (C22H32O2)
- Omega-3 Acids
| Supplement Facts | ||
|---|---|---|
| Name: | DHA-500/EPA-250, Double Strength, 180 Softgels | |
| Serving Size: | 1 Softgel | |
| Serving Per Container: | 90 | |
| Amount Per Serving | %Daily Value | |
| Calories | 10 | |
| Total Fat | 1 g | 1%×) |
| Polyunsaturated Fat | 1 g | † |
| Cholesterol | 0 mg | 0% |
| Natural Fish Oil Concentrate | 1 g (1,000 mg) | † |
| Omega-3 Fatty Acids: | ||
| Docosahexaenoic Acid (DHA) | 500 mg | † |
| Eicosapentaenoic Acid (EPA) | 250 mg | † |
| ×) Percent Daily Values are based on a 2,000 calorie diet. † Daily Value not established. |
||
| Manufacturer: | Now Foods |
|---|---|
| Manufacturer Code: | 01613 |
| UPC Code (gtin12): | 733739016133 |
| Package Quantity | |
| Count | 180 |
Other ingredients
Softgel capsule (bovine gelatin, glycerin, enteric coating, water) and vitamin E (as natural d-alpha tocopherol).
Contains fish (tuna). Vitamin E from soy.
DHA-500/EPA-250, Double Strength, 180 Softgels – Suggested Use
Take 1 softgel 1 to 2 times daily with food.
| Recommended Intake | |||
|---|---|---|---|
| Dose Unit | Dose Value | Frequency | Target Population |
| softgel | 1 | 1 to 2 times daily | adults |
Warnings
- Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease.
- Not manufactured with yeast, wheat, gluten, milk, egg or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
- Caution: For adults only. Consult physician if pregnant/nursing, taking medication, or have a medical condition. Keep out of reach of children.
- Natural color variation may occur in this product.
- Do Not Eat Freshness Packet. Keep in Bottle.
- Store in a cool, dry place after opening.
Dietary supplements similar to DHA-500/EPA-250, Double Strength, 180 Softgels (Now Foods)
The DHA-500/EPA-250, Double Strength, 180 Softgels (Now Foods) dietary supplement is available in Madagascar and many others countries around the world. In Madagascar this supplement contains: DHA, EPA, Fish Oil and Omega-3 Acids in its composition.
Detailed descriptions of the ingredients included in the DHA-500/EPA-250, Double Strength, 180 Softgels (Now Foods) dietary supplement:
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