Bazinet Richard P., et al.
Brain, behavior, and immunity, 2019
Abstract
The results of several meta-analyses suggest that eicosapentaenoic acid (EPA) supplementation is therapeutic in managing the symptoms of major depression. It was previously assumed that because EPA is extremely low in the brain it did not cross the blood-brain barrier and any therapeutic effects it exerted would be via the periphery. However, more recent studies have established that EPA does enter the brain, but is rapidly metabolised following entry. While EPA does not accumulate within the brain, it is present in microglia and homeostatic mechanisms may regulate its esterification to phospholipids that serve important roles in cell signaling. Furthermore, a variety of signaling molecules from EPA have been described in the periphery and they have the potential to exert effects within the brain. If EPA is confirmed to be therapeutic in major depression as a result of adequately powered randomized clinical trials, future research on brain EPA metabolism could lead to the discovery of novel targets for treating or preventing major depression.
Copyright © 2019. Published by Elsevier Inc.
| PMID: | 31278982 |
|---|---|
| DOI: | 10.1016/j.bbi.2019.07.001 |
| Category: | Brain / Mental Clarity |
The best supplements with Eicosapentaenoic Acid in Brain / Mental Clarity category:
- Liquid Omega-3, Deep Sea Fish Oil EPA/DHA, Natural Orange Flavor, 16 fl oz (480 ml) (Nature's Answer) -
Omega-3 Fish Oil provides, molecularly distilled, nitrogen flushed fish body oil, harvested in the cold, clean waters of the North Atlantic. It contains among others: Eicosapentaenoic Acid.
- Marine Algae Derived Vegan Omega-3, 120 Softgels (Zenwise Health) - M It contains among others: Eicosapentaenoic Acid.
- Omega-3 Fish Oil, Ultra-Pure Cold-Water Fish Oil, 180 Softgels (ALLMAX Nutrition) - Athletes have long known the power of Deep Cold-Water fish oil to attain peak physical performance. It contains among others: Eicosapentaenoic Acid.
- Fish Oil, 1,000 mg, 300 Softgels (21st Century) - EPA and DHA are important Omega-3 fatty acids that supports cardiovascular health as well as being important components of the cells in the body. It contains among others: Eicosapentaenoic Acid.
- Omega-3, EPA & DHA, Triple Strength, 950 mg, 50 Softgels (Solgar) - Omega 3 950 mg is Solgar's highest concentration of the natural Omega 3 polyunsaturates EPA and DHA from cold-water fish. It contains among others: Eicosapentaenoic Acid.
- Omega-3, EPA & DHA, Triple Strength, 950 mg, 100 Softgels (Solgar) - Omega 3 950 mg is Solgar’s highest concentration of the natural Omega 3 polyunsaturates EPA and DHA from cold-water fish. It contains among others: Eicosapentaenoic Acid.
- Tri-3D Omega, 330 EPA/220 DHA, 90 Softgels (Now Foods) - The natural fish oil concentrate used in this softgel is manufactured under strict quality control standards. It contains among others: Eicosapentaenoic Acid.
- Omega-3, 180 Softgels (Now Foods) - The natural fish oil concentrate is manufactured under strict quality control standards. It contains among others: Eicosapentaenoic Acid.
- Neptune Krill Oil, 500 mg, 120 Softgels (Now Foods) - NKO (Neptune Krill Oil) (Euphausia Superba) is known for its unique fatty acid (FA) profile, which includes EPA and DHA, plus phospholipids. It contains among others: Eicosapentaenoic Acid.
- High Lignan Flax Oil, 1,000 mg, 120 Softgels (Now Foods) - Flax Oil (Linum Usitatissimum) is a natural reservoir for the omega-3 fatty acid, Alpha-Linolenic Acid (ALA). It contains among others: Eicosapentaenoic Acid.
- Omega-3, Molecularly Distilled, 30 Softgels (Now Foods) - This natural fish oil concentrate is manufactured under strict quality control standards. It contains among others: Eicosapentaenoic Acid.
- Omega-3 Mini Gels, 180 Softgels (Now Foods) - The Natural Fish Oil concentrate used in this softgel is manufactured under strict quality control standards. It contains among others: Eicosapentaenoic Acid.
- Super Omega EPA, Molecularly Distilled, 240 Softgels (Now Foods) - NOW Super Omega EPA has twice the EPA (360 mg per softgel) as in our regular strength product (180 mg per softgel). It contains among others: Eicosapentaenoic Acid.
- DHA-500/EPA-250, Double Strength, 180 Softgels (Now Foods) - NOW DHA-500 has twice the DHA (500 mg per softgel) as in our regular strength product (250 mg per softgel). It contains among others: Eicosapentaenoic Acid.
- Ultra Omega-3, 500 EPA/250 DHA, 90 Softgels (Now Foods) - Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease. It contains among others: Eicosapentaenoic Acid.
- Ultra Omega-3, 500 EPA/250 DHA, 180 Softgels (Now Foods) - The Natural Fish Oil Concentrate used in this softgel is manufactured under strict quality control standards. It contains among others: Eicosapentaenoic Acid.
- Kid's Chewable DHA, Fruit Flavor, 60 Softgels (Now Foods) - K It contains among others: Eicosapentaenoic Acid.
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