Balakumar Pitchai, Taneja Gaurav
Free Radical Biology and Medicine, 2012
Abstract
Fish oil is recommended for the management of hypertriglyceridemia and to prevent secondary cardiovascular disorders. Fish oil is a major source of ω-3-polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Clinical studies suggest that fish oil not only prevents the incidence of detrimental cardiovascular events, but also lowers the cardiovascular mortality rate. In addition to a classic lipid-lowering action, ω-3-PUFAs in fish oil could regulate blood pressure and enhance vascular integrity and compliance. Additionally, ω-3-PUFAs have the ability to protect vascular endothelial cells by decreasing oxidative stress, halting atherosclerotic events, and preventing vascular inflammatory and adhesion cascades. Intriguingly, recent studies have demonstrated that ω-3-PUFAs improve the function of vascular endothelium by enhancing the generation and bioavailability of endothelium-derived relaxing factor (nitric oxide) through upregulation and activation of endothelial nitric oxide synthase (eNOS). This certainly opens up a new area of research identifying potential mechanisms influencing fish oil-mediated functional regulatory action on vascular endothelium. We address in this review the potential of fish oil to prevent vascular endothelial dysfunction and associated cardiovascular disorders. Moreover, the mechanisms pertaining to fish oil-mediated eNOS activation and nitric oxide generation in improving endothelial function are delineated. We finally suggest the importance of further studies to determine the dose adjustment of fish oil with an optimal ratio of EPA and DHA for achieving consistent cardiovascular protection.
Copyright © 2012 Elsevier Inc. All rights reserved.
| PMID: | 22584102 |
|---|---|
| DOI: | 10.1016/j.freeradbiomed.2012.05.005 |
| Category: | Cardiovascular Support |
The best supplements with Fish Oil in Cardiovascular Support category:
- Organic Flax Seed Oil, 1,000 mg, 90 Softgels (Zahler) - Cold Pressed Flaxseed OilZehaler Flaxseed Oil is high in alpha-linolenic acid (ALA), which is partially converted by the body into other important nutrients like DHA and EPA, Cold pressed from organic flax seeds, Zahler's Flaxseed Oil is 100% pure and natural, unmodified by chemical refinements. It contains among others: Fish Oil.
- Liquid Omega-3, Deep Sea Fish Oil EPA/DHA, Natural Orange Flavor, 16 fl oz (480 ml) (Nature's Answer) -
Omega-3 Fish Oil provides, molecularly distilled, nitrogen flushed fish body oil, harvested in the cold, clean waters of the North Atlantic. It contains among others: Fish Oil.
- Liquid Norwegian Cod Liver Oil, Natural Lemon-Lime Flavor, 16 fl oz (480 ml) (Nature's Answer) - Nature’s Answer Liquid Cod Liver Oil is harvested from the deep, clean, cold waters of the North Atlantic. It contains among others: Fish Oil.
- Marine Algae Derived Vegan Omega-3, 120 Softgels (Zenwise Health) - M It contains among others: Fish Oil.
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- Omega-3, EPA & DHA, Triple Strength, 950 mg, 50 Softgels (Solgar) - Omega 3 950 mg is Solgar's highest concentration of the natural Omega 3 polyunsaturates EPA and DHA from cold-water fish. It contains among others: Fish Oil.
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- Tri-3D Omega, 330 EPA/220 DHA, 90 Softgels (Now Foods) - The natural fish oil concentrate used in this softgel is manufactured under strict quality control standards. It contains among others: Fish Oil.
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- Omega 3-6-9, 1000 mg, 250 Softgels (Now Foods) - Omega 3-6-9 is a blend of Flax-Seed (Linum Usitatissimum), Evening Primrose (Oenothera Biennis), Canola (Brassica Napus) / Omega-9 / Erucic Acid , Black Currant Seed Oils (Ribes Nigrum) - which contains: EPA, DHA, ALA, GLA and Linoleic Acid; and Pumpkin Seed Oils (Cucurbita Pepo). It contains among others: Fish Oil.
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- Ultra Omega 3-D, 600 EPA/300 DHA, 180 Softgels (Now Foods) - Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease. It contains among others: Fish Oil.
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