Solfrizzi Vincenzo, Panza Francesco
Journal of Alzheimer's Disease, 2015
Abstract
Among nutraceuticals and nutritional bioactive compounds, the standardized Ginkgo biloba extract EGb 761 is the most extensively clinically tested herbal-based substance for cognitive impairment, dementia, and Alzheimer's disease (AD). In the last three years, notwithstanding negative meta-analytic findings and the discouraging results of preventive trials against AD, some randomized controlled trials focusing particularly on dementia, AD, and mild cognitive impairment (MCI) subgroups with neuropsychiatric symptoms (NPS) and some recent meta-analyses have suggested a renowned role for EGb 761 for cognitive impairment and dementia. Meta-analytic findings suggested overall benefits of EGb 761 for stabilizing or slowing decline in cognition of subjects with cognitive impairment and dementia. The safety and tolerability of EGb 761 appeared to be excellent at different doses. Subgroup analyses showed that these clinical benefits of EGb 761 were mainly associated with the 240 mg/day dose, and also confirmed in the AD subgroup. More importantly, one of these meta-analyses showed clinical benefits in cognition, behavior, functional status, and global clinical change of EGb 761 at a dose of 240 mg/day in the treatment of patients with dementia, AD, and MCI with NPS. The inclusion of the recent randomized controlled trials focusing on dementia, AD, and MCI subgroups with NPS may partly explain the conflicting results of these recent meta-analyses and previous pooled findings.
| PMID: | 25352453 |
|---|---|
| Category: | Brain / Mental Clarity |
The best supplements with Ginkgo Biloba in Brain / Mental Clarity category:
- Brain Pill - „An amazing new product that supports your brain health and has the potential to change your life returning laser-sharp mental clarity” - Dr Dave David, a surgeon and physician for more than 37 years. It contains among others: Ginkgo Biloba.
- Pure Nootropics Ginkgo Biloba Capsules - Ginkgo Biloba leaves contain two phytochemical compounds that are believed to provide benefits: flavonoids (plant-based antioxidants) and terpenoids. It contains among others: Ginkgo Biloba.
- Vitabase - Ginkgo (120 mg) - Vitabase - Ginkgo (120 mg) Standardized Extract is a very powerful antioxidant, especially for the cardiovascular and nervous systems. It contains among others: Ginkgo Biloba.
- Vitabase - Brain Support - Vitabase - Brain Support is a combination of six different herbs and ingredients designed to help support brain function. It contains among others: Ginkgo Biloba.
Articles similar to "Plant-based nutraceutical interventions against cognitive impairment and dementia: meta-analytic evidence of efficacy of a standardized Gingko biloba extract."
- The significance of Ginkgo Biloba for Brain / Mental Clarity: A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group. (CONTEXT: EGb 761 is a particular extract of Ginkgo biloba used in Europe to alleviate symptoms associated with numerous cognitive disorders... EGb was safe and appears capable of stabilizing and, in a substantial number of cases, improving the cognitive performance and the social functioning of demented patients for 6 months to 1 year. Although modest, the changes induced by EGb were objectively measured by the ADAS-Cog and were of sufficient magnitude to be recognized by the caregivers in the GERRI.)
- The role of Ginkgo Biloba in Brain / Mental Clarity: Central additive effect of Ginkgo biloba and Rhodiola rosea on psychomotor vigilance task and short-term working memory accuracy. (AIM: The present study investigates the effect of combined treatment with Ginkgo biloba and/or Rhodiola rosea on psychomotor vigilance task (PVT) and short-term working memory accuracy... The combined effect of R. rosea and G. biloba leading to a more significant effect on cognitive function than either G. biloba or R. rosea when they used alone.)
- The impact of Ginkgo Biloba on Brain / Mental Clarity: Ginkobiloba extract improves working memory performance in middle-aged women: role of asymmetry of prefrontal cortex activity during a working memory task. (In order to clarify the mechanism through which extract of Ginkgo biloba leaves (EGb) improves cognitive function, we examined the effects of EGb on cerebral blood oxygenation in the prefrontal cortex (PFC) and on performance during a working memory task, using near-infrared spectrometry (NIRS)... The combined effect of R. rosea and G. biloba leading to a more significant effect on cognitive function than either G. biloba or R. rosea when they used alone.)
- The role of Ginkgo Biloba in Brain / Mental Clarity: Effects of Ginkgo biloba on mental functioning in healthy volunteers. ( There has been a lack of investigations examining the effects of Ginkgo biloba extract EGb 761 on mental functions and quality of life in healthy subjects with no cognitive impairment... Both questions treated in this study, efficacy and safety, are important from a medical perspective because many persons take the agent studied in an effort to enhance their mental functioning and general well-being. The findings of this study support the adequacy of intake of EGb 761 to improve the functions indicated previously.)
- The impact of Ginkgo Biloba on Brain / Mental Clarity: Specific memory effects of Ginkgo biloba extract EGb 761 in middle-aged healthy volunteers. (INTRODUCTION: Recent reviews showed that Ginkgo biloba extract EGb 761(1) is effective to enhance performance in patients with cognitive impairment (e... Both questions treated in this study, efficacy and safety, are important from a medical perspective because many persons take the agent studied in an effort to enhance their mental functioning and general well-being. The findings of this study support the adequacy of intake of EGb 761 to improve the functions indicated previously.)
- The significance of Ginkgo Biloba for Brain / Mental Clarity: Safety and effectiveness of a traditional ginkgo fresh plant extract–results from a clinical trial. ( In Chinese medicine, Ginkgo biloba is used for a variety of indications... This newly developed, holistic fresh leaf extract of Ginkgo biloba is a safe, effective, and, at least, adjuvant treatment option for patients with mild cognitive impairments.)
- The role of Ginkgo Biloba in Brain / Mental Clarity: The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers. (RATIONALE: Chronic administration of extracts from the leaves of the tree Ginkgo biloba is known to improve aspects of cognitive performance... We conclude that acute administration of Ginkgo biloba is capable of producing a sustained improvement in attention in healthy young volunteers.)
- The impact of Ginkgo Biloba on Brain / Mental Clarity: Effects of Ginkgo biloba on mental functioning in healthy volunteers. ( There has been a lack of investigations examining the effects of Ginkgo biloba extract EGb 761 on mental functions and quality of life in healthy subjects with no cognitive impairment... Both questions treated in this study, efficacy and safety, are important from a medical perspective because many persons take the agent studied in an effort to enhance their mental functioning and general well-being. The findings of this study support the adequacy of intake of EGb 761 to improve the functions indicated previously.)
- The significance of Ginkgo Biloba for Brain / Mental Clarity: Cardioprotective action of ginkgo biloba extract against sustained β-adrenergic stimulation occurs via activation of M2/NO pathway. (Ginkgo biloba is the most popular phytotherapic agent used worldwide for treatment of several human disorders... Both questions treated in this study, efficacy and safety, are important from a medical perspective because many persons take the agent studied in an effort to enhance their mental functioning and general well-being. The findings of this study support the adequacy of intake of EGb 761 to improve the functions indicated previously.)