What are the properties of Vitamin D3 in supplements?

The Supplements with Vitamin D3The Supplements with Vitamin D3

The properties of Vitamin D3

Cholecalciferol, also known as vitamin D3 and colecalciferol, is a type of vitamin D which is made by the skin when exposed to sunlight; it is also found in some foods and can be taken as a dietary supplement. It is used to treat and prevent vitamin D deficiency and associated diseases, including rickets. It is also used for familial hypophosphatemia, hypoparathyroidism that is causing low blood calcium, and Fanconi syndrome. It is usually taken by mouth.

Vitamin D is a fat soluble vitamin important in the regulation of calcium metabolism and bone health and deficiency of which cause rickets, a disease marked by lack of mineralization of bone. Conventional doses of vitamin D are well tolerated without appreciable adverse effects. High doses of vitamin D can be toxic, leading to a constellation of signs and symptoms but not liver injury or jaundice.

In humans, evidence exists on associations between vitamin D deficiency and impaired immune function, leading to autoimmunity in genetically predisposed people and increased risk for infections(889).

Vitamin D regulates both adaptive and innate immunity as well as inflammatory cascade on the cellular level(891).

Vitamin D is important for both cellular metabolism and immunity, as it controls calcium homeostasis and modulates the response of the innate and adaptive immune system. At sufficient UV-B exposure, humans can synthesize vitamin D₃ endogenously in their skin, but today's lifestyle often makes the molecule a true vitamin and micronutrient that needs to be taken up by diet or supplementation with pills.

The individual's molecular response to vitamin D requires personalized supplementation with vitamin D₃, in order to obtain optimized clinical benefits in the prevention of osteoporosis, sarcopenia, autoimmune diseases, and possibly different types of cancer(893).

Vitamin D and human skin. Vitamin D3 is synthesized endogenously in UV-B exposed human skin
Vitamin D and human skin. Vitamin D3 is synthesized endogenously in UV-B exposed human skin (A). During the past 10–30,000 years this essential need to synthesize vitamin D3 was an evolutionary driver for skin lightening of modern humans migrating from Africa towards Europe and Asia (B).

Cholecalciferol - Description from DrugBank

 

Cholecalciferol - Description from NCI Thesaurus

 

Cholecalciferol - Description from HMDB

 


The supplements containing Vitamin D3


Chewable Vitamin D-3, Natural Fruit Flavor, 1,000 IU, 180 Chewables (Now Foods)Chewable Vitamin D-3, Natural Fruit Flavor, 1,000 IU, 180 Chewables (Now Foods)

English version


Chewable Vitamin D-3, Natural Fruit Flavor, 1,000 IU, 180 Chewables (Now Foods) contains amoung others Vitamin D3.

Chewable Vitamin D-3, Natural Fruit Flavor, 1,000 IU, 180 Chewables (Now Foods) is available in many countries around the world.

If you are not in The United Kingdom (GB)
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Now Chewable Vitamin D-3 supplies this key vitamin in a tasty chewable form. Vitamin D is normally obtained from the diet or produced by the skin from the ultraviolet energy of the sun. However, it is not abundant in food. As more people avoid sun exposure, Vitamin D supplementation becomes even...
Vitamin D-3 High Potency, 1,000 IU, 360 Softgels (Now Foods)Vitamin D-3 High Potency, 1,000 IU, 360 Softgels (Now Foods)

English version


Vitamin D-3 High Potency, 1,000 IU, 360 Softgels (Now Foods) contains amoung others Vitamin D3.

Vitamin D-3 High Potency, 1,000 IU, 360 Softgels (Now Foods) is available in many countries around the world.

If you are not in The United Kingdom (GB)
>> Select Your Country <<


 
NOW Vitamin D-3 softgels supply this key vitamin in a highly-absorbable liquid softgel form. Vitamin D is normally obtained from the diet. or produced by the skin from the ultraviolet energy of the sun. However, it is not abundant in food. As more people avoid sun exposure, Vitamin D...
Calcium & Magnesium, with Vitamin D-3 and Zinc, 240 Softgels (Now Foods)Calcium & Magnesium, with Vitamin D-3 and Zinc, 240 Softgels (Now Foods)

English version


Calcium & Magnesium, with Vitamin D-3 and Zinc, 240 Softgels (Now Foods) contains amoung others Vitamin D3.

Calcium & Magnesium, with Vitamin D-3 and Zinc, 240 Softgels (Now Foods) is available in many countries around the world.

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NOW Calcium & Magnesium Softgels include Vitamin D-3 and Zinc, offering a truly balanced blend of essential minerals. This formula supports strong bones and teeth, as well as healthy enzymatic activity. Delivered via softgel, this formula is more easily absorbed and assimilated than capsules or...
D3, 25 mcg (1,000 IU), 110 Tablets (21st Century)D3, 25 mcg (1,000 IU), 110 Tablets (21st Century)

English version


D3, 25 mcg (1,000 IU), 110 Tablets (21st Century) contains amoung others Vitamin D3.

D3, 25 mcg (1,000 IU), 110 Tablets (21st Century) is available in many countries around the world.

If you are not in The United Kingdom (GB)
>> Select Your Country <<


 
Vitamin D3 is essential for absorption of calcium and support bone, teeth, and immune system health.
Vitamin D-3, High Potency, 5,000 IU, 120 Softgels (Now Foods)Vitamin D-3, High Potency, 5,000 IU, 120 Softgels (Now Foods)

English version


Vitamin D-3, High Potency, 5,000 IU, 120 Softgels (Now Foods) contains amoung others Vitamin D3.

Vitamin D-3, High Potency, 5,000 IU, 120 Softgels (Now Foods) is available in many countries around the world.

If you are not in The United Kingdom (GB)
>> Select Your Country <<


 
NOW Vitamin D-3 softgels supply this key vitamin in a highly-absorbable liquid softgel form. Vitamin D is normally obtained from the diet or produced by the skin from the ultraviolet energy of the sun. However, is it not abundant in food. As more people avoid sun exposure, Vitamin D supplementation...
Vitamin D-3, High Potency, 2,000 IU, 30 Softgels (Now Foods)Vitamin D-3, High Potency, 2,000 IU, 30 Softgels (Now Foods)

English version


Vitamin D-3, High Potency, 2,000 IU, 30 Softgels (Now Foods) contains amoung others Vitamin D3.

Vitamin D-3, High Potency, 2,000 IU, 30 Softgels (Now Foods) is available in many countries around the world.

If you are not in The United Kingdom (GB)
>> Select Your Country <<


 
NOW Vitamin D-3 softgels supply this key vitamin in a highly absorbable liquid softgel form. Vitamin D is normally obtained from the diet or produced by the skin from the ultraviolet energy of the sun. However, it is not abundant in food. As more people avoid sun exposure, vitamin D supplementation...
Bone Strength, 240 Capsules (Now Foods)Bone Strength, 240 Capsules (Now Foods)

English version


Bone Strength, 240 Capsules (Now Foods) contains amoung others Vitamin D3.

Bone Strength, 240 Capsules (Now Foods) is available in many countries around the world.

If you are not in The United Kingdom (GB)
>> Select Your Country <<


 
Microcrystalline Hydroxyapatite (MCHA) is a compound that normally makes up the crystalline matrix of bone and teeth and is the substance that gives them their rigidity. MCHA contains highly absorbable Calcium and Phosphorus, which are the major mineral components of bone. Now Bone Strength is a...
Vitamin D-3 High Potency, 10,000 IU, 120 Softgels (Now Foods)Vitamin D-3 High Potency, 10,000 IU, 120 Softgels (Now Foods)

English version


Vitamin D-3 High Potency, 10,000 IU, 120 Softgels (Now Foods) contains amoung others Vitamin D3.

Vitamin D-3 High Potency, 10,000 IU, 120 Softgels (Now Foods) is available in many countries around the world.

If you are not in The United Kingdom (GB)
>> Select Your Country <<


 
NOW Vitamin D-3 softgels supply this key vitamin in a highly-absorbable liquid softgel form. Vitamin D is normally obtained from the diet or produced by the skin from the ultraviolet energy of the sun. However, it is not abundant in food. As more people avoid sun exposure, Vitamin D supplementation...
Vitamin D-3, High Potency, 5,000 IU, 240 Softgels (Now Foods)Vitamin D-3, High Potency, 5,000 IU, 240 Softgels (Now Foods)

English version


Vitamin D-3, High Potency, 5,000 IU, 240 Softgels (Now Foods) contains amoung others Vitamin D3.

Vitamin D-3, High Potency, 5,000 IU, 240 Softgels (Now Foods) is available in many countries around the world.

If you are not in The United Kingdom (GB)
>> Select Your Country <<


 
NOW Vitamin D-3 softgels supply this key vitamin in a highly-absorbable liquid softgel form. Vitamin D is normally obtained from the diet or produced by the skin from the ultraviolet energy of the sun. However, it is not abundant in food. As more people avoid sun exposure, Vitamin D supplementation...
Clinical Strength Prostate Health, 180 Softgels (Now Foods)Clinical Strength Prostate Health, 180 Softgels (Now Foods)

English version


Clinical Strength Prostate Health, 180 Softgels (Now Foods) contains amoung others Vitamin D3.

Clinical Strength Prostate Health, 180 Softgels (Now Foods) is available in many countries around the world.

If you are not in The United Kingdom (GB)
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NOW Clinical Strength Prostate Health is a combination of botanicals and nutrients that support a healthy prostate gland. Clinical Strength Prostate Health features the botanicals Saw Palmetto Extract, Lycopene and Beta-Sitosterol at potencies that are comparable to those that have been used in...
Vitamin D-3 High Potency , 2,000 IU, 120 Softgels (Now Foods)Vitamin D-3 High Potency , 2,000 IU, 120 Softgels (Now Foods)

English version


Vitamin D-3 High Potency , 2,000 IU, 120 Softgels (Now Foods) contains amoung others Vitamin D3.

Vitamin D-3 High Potency , 2,000 IU, 120 Softgels (Now Foods) is available in many countries around the world.

If you are not in The United Kingdom (GB)
>> Select Your Country <<


 
NOW Vitamin D-3 softgels supply this key vitamin in a highly-absorbable liquid softgel form. Vitamin D is normally obtained from the diet or produced by the skin from the ultraviolet energy of the sun. However, it is not abundant in food. As more people avoid sun exposure, Vitamin D supplementation...
Tri-3D Omega, 330 EPA/220 DHA, 90 Softgels (Now Foods)Tri-3D Omega, 330 EPA/220 DHA, 90 Softgels (Now Foods)

English version


Tri-3D Omega, 330 EPA/220 DHA, 90 Softgels (Now Foods) contains amoung others Vitamin D3.

Tri-3D Omega, 330 EPA/220 DHA, 90 Softgels (Now Foods) is available in many countries around the world.

If you are not in The United Kingdom (GB)
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The natural fish oil concentrate used in this softgel is manufactured under strict quality control standards. It is tested to be free of potentially harmful levels of contaminants (i.e. mercury, heavy metals, PCB's, dioxins, and other contaminants).
Vitamin D-3 High Potency, 2,000 IU, 240 Softgels (Now Foods)Vitamin D-3 High Potency, 2,000 IU, 240 Softgels (Now Foods)

English version


Vitamin D-3 High Potency, 2,000 IU, 240 Softgels (Now Foods) contains amoung others Vitamin D3.

Vitamin D-3 High Potency, 2,000 IU, 240 Softgels (Now Foods) is available in many countries around the world.

If you are not in The United Kingdom (GB)
>> Select Your Country <<


 
NOW Vitamin D-3 softgels supply this key vitamin in a highly-absorbable liquid softgel form. Vitamin D is normally obtained from the diet or produced by the skin from the ultraviolet energy of the sun. However, it is not abundant in food. As more people avoid sun exposure, Vitamin D supplementation...
Magnesium & Calcium, Reverse 2:1 Ratio with Zinc and Vitamin D-3, 100 Tablets (Now Foods)Magnesium & Calcium, Reverse 2:1 Ratio with Zinc and Vitamin D-3, 100 Tablets (Now Foods)

English version


Magnesium & Calcium, Reverse 2:1 Ratio with Zinc and Vitamin D-3, 100 Tablets (Now Foods) contains amoung others Vitamin D3.

Magnesium & Calcium, Reverse 2:1 Ratio with Zinc and Vitamin D-3, 100 Tablets (Now Foods) is available in many countries around the world.

If you are not in The United Kingdom (GB)
>> Select Your Country <<


 
This reverse ratio formula is formulated to provide higher levels of Magnesium for those who desire the never, muscle and bone supporting effects of this essential mineral. Zinc and Vitamin D-3 are included in this product for their roles in bone metabolism.
Vitamin D-3 & K-2, Liposomal Spray, D-3 1,000 IU / K-2 100 mcg, 2 fl oz (59 ml) (Now Foods)Vitamin D-3 & K-2, Liposomal Spray, D-3 1,000 IU / K-2 100 mcg, 2 fl oz (59 ml) (Now Foods)

English version


Vitamin D-3 & K-2, Liposomal Spray, D-3 1,000 IU / K-2 100 mcg, 2 fl oz (59 ml) (Now Foods) contains amoung others Vitamin D3.

Vitamin D-3 & K-2, Liposomal Spray, D-3 1,000 IU / K-2 100 mcg, 2 fl oz (59 ml) (Now Foods) is available in many countries around the world.

If you are not in The United Kingdom (GB)
>> Select Your Country <<


 
Now Vitamin D-3 & K-2 Liposomal Spray combines two nutrients known for their benefits in bones, teeth and the cardiovascular system.
DuphaVit Pregna, kapsułki miękkie, 30 szt. / (Emergopharm)DuphaVit Pregna, kapsułki miękkie, 30 szt. / (Emergopharm)

Polish version


DuphaVit Pregna, kapsułki miękkie, 30 szt. / (Emergopharm) contains amoung others Vitamin D3.

DuphaVit Pregna, kapsułki miękkie, 30 szt. / (Emergopharm) is available exlusively in Poland.


 
DuphaVit Pregna - suplement diety zawierający w swoim składzie foliany, kwas DHA, żelazo, jod oraz witaminę D. Produkt przeznaczony dla kobiet w ciąży i karmiących piersią.
Femibion Planowanie ciąży, tabletki powlekane, 28 szt. / (Merck)Femibion Planowanie ciąży, tabletki powlekane, 28 szt. / (Merck)

Polish version


Femibion Planowanie ciąży, tabletki powlekane, 28 szt. / (Merck) contains amoung others Vitamin D3.

Femibion Planowanie ciąży, tabletki powlekane, 28 szt. / (Merck) is available exlusively in Poland.


 
Femibion Planowanie ciąży - suplement diety zawierający składniki odżywcze, które wspomagają przygotować organizm do ciąży. Produkt przeznaczony dla osób dorosłych.
Doppelherz aktiv Aktiv-Meno Forte, tabletki, 30 szt. / (Queisser)Doppelherz aktiv Aktiv-Meno Forte, tabletki, 30 szt. / (Queisser)

Polish version


Doppelherz aktiv Aktiv-Meno Forte, tabletki, 30 szt. / (Queisser) contains amoung others Vitamin D3.

Doppelherz aktiv Aktiv-Meno Forte, tabletki, 30 szt. / (Queisser) is available exlusively in Poland.


 
Doppelherz aktiv Aktiv-Meno Forte - suplement diety, zawierający unikalną kombinacje 13 aktywnych składników, z najwyższą łączną dawką izoflawonów sojowych i wyciągu z szyszek chmielu (Humulus Lupulus).
Protego Witamina D 1000 j.m, kapsułki elastyczne, 60 szt. / (Laboratories Salvum)Protego Witamina D 1000 j.m, kapsułki elastyczne, 60 szt. / (Laboratories Salvum)

Polish version


Protego Witamina D 1000 j.m, kapsułki elastyczne, 60 szt. / (Laboratories Salvum) contains amoung others Vitamin D3.

Protego Witamina D 1000 j.m, kapsułki elastyczne, 60 szt. / (Laboratories Salvum) is available exlusively in Poland.


 
Protego Witamina D 1000 - suplement diety przeznaczony dla dzieci i osób dorosłych.

If you know of any other quality supplement that has not been yet classified by us, please contact us and we will gladly consider adding it to our catalogue.


Vitamin D3 (cholecalciferol) - References & External links

Vitamin D3 (Cholecalciferol)

TBS Ingredient ID (TBSI ID):
Name
Vitamin D3
Synonyms:
Calciol, Colecalciferol
Chemical Formula:
C27H44O
Molecular Formula:
Cholecalciferol - Molecular Formula
Classification TypeIdentifier
PubChem CID:
U.S. National Library of Medicine (PubChem)
InChI Key:
International Chemical Identifier hash (InChIKey) computed from chemical structure using the International Union of Pure and Applied Chemistry (IUPAC) standard
QYSXJUFSXHHAJI-YRZJJWOYSA-N
CAS:
A proprietary registry number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society (ACS)
67-97-0
NIST:
The National Institute of Standards and Technology (NIST)
ChemIDplus:
United States National Library of Medicine - TOXNET (Toxicology Data Network).
EC Number:
A seven-digit regulatory identifier currently assigned by the European Chemicals Agency (ECHA) known as a European Community (EC) number
215-797-2
DrugBank:
The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug data with comprehensive drug target information.

Show: Cholecalciferol - description from DrugBank
ATC code:
WHO ATC Classification System. The Anatomical Therapeutic Chemical (ATC) Classification System is used for the classification of drugs. This pharmaceutical coding system divides drugs into different groups according to the organ or system on which they act and/or their therapeutic and chemical characteristics
ChEMBL:
An open data resource of binding, functional and ADMET bioactivity data (ChEMBL)
HMDB:
The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.

Show: Cholecalciferol - description from HMDB
NCI Thesaurus:
National Cancer Institute - NCI.

Show: Cholecalciferol - description from NCI Thesaurus
UNII:
FDA Substance Registration System - Unique Ingredient Identifier

The references to scientific articles about Vitamin D3 (cholecalciferol) are not meant to imply that any products treat, cure, or diagnose any disease or human condition. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.