Cannabidiol as a Potential Treatment for Anxiety Disorders.

Blessing Esther M., et al.
Neurotherapeutics, 2015

Abstract

Cannabidiol (CBD), a Cannabis sativa constituent, is a pharmacologically broad-spectrum drug that in recent years has drawn increasing interest as a treatment for a range of neuropsychiatric disorders. The purpose of the current review is to determine CBD's potential as a treatment for anxiety-related disorders, by assessing evidence from preclinical, human experimental, clinical, and epidemiological studies. We found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder when administered acutely; however, few studies have investigated chronic CBD dosing. Likewise, evidence from human studies supports an anxiolytic role of CBD, but is currently limited to acute dosing, also with few studies in clinical populations. Overall, current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders, with need for further study of chronic and therapeutic effects in relevant clinical populations.

Keywords

Anxiety; Cannabidiol; Endocannabinoids; Generalized anxiety disorder; Post-traumatic stress disorder.

PMID:26341731
DOI:10.1007/s13311-015-0387-1
PMCID (Free PMC Article):PMC4604171
Category:Brain / Mental Clarity

The best supplements with Cannabidiol in Brain / Mental Clarity category:

Articles similar to "Cannabidiol as a Potential Treatment for Anxiety Disorders."

  • The significance of Cannabidiol for Brain / Mental Clarity: Antidepressant-like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa. (Anxiety and depression are pathologies that affect human beings in many aspects of life, including social life, productivity and health...)
  • The role of Cannabidiol in Brain / Mental Clarity: A Systematic Review of the Effect of Cannabidiol on Cognitive Function: Relevance to Schizophrenia. (Background and objectives: Cognitive impairment is a core symptom domain of schizophrenia, neurological disorders and substance abuse... The efficacy of CBD to improve cognition in schizophrenia cannot be elucidated due to lack of clinical evidence; however, given the ability of CBD to restore cognition in multiple studies of impairment, further investigation into its efficacy in schizophrenia is warranted. Potential mechanisms underlying the efficacy of CBD to improve cognition are discussed. )
  • The impact of Cannabidiol on Brain / Mental Clarity: Evidences for the Anti-panic Actions of Cannabidiol. ( Panic disorder (PD) is a disabling psychiatry condition that affects approximately 5% of the worldwide population...)
  • The role of Cannabidiol in Brain / Mental Clarity: Cannabidiol, a Cannabis Sativa Constituent, as an Anxiolytic Drug. (Objectives: To review and describe studies of the non-psychotomimetic constituent of Cannabis sativa, cannabidiol (CBD), as an anxiolytic drug and discuss its possible mechanisms of action... Future clinical trials involving patients with different anxiety disorders are warranted, especially of panic disorder, obsessive-compulsive disorder, social anxiety disorder, and post-traumatic stress disorders. The adequate therapeutic window of CBD and the precise mechanisms involved in its anxiolytic action remain to be determined.)
  • The impact of Cannabidiol on Brain / Mental Clarity: Cannabidiol, a Cannabis Sativa Constituent, as an Antipsychotic Drug. (A high dose of delta9-tetrahydrocannabinol, the main Cannabis sativa (cannabis) component, induces anxiety and psychotic-like symptoms in healthy volunteers... Future clinical trials involving patients with different anxiety disorders are warranted, especially of panic disorder, obsessive-compulsive disorder, social anxiety disorder, and post-traumatic stress disorders. The adequate therapeutic window of CBD and the precise mechanisms involved in its anxiolytic action remain to be determined.)
  • The significance of Cannabidiol for Brain / Mental Clarity: Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors. (The broad presence of CB1 receptors in the basal ganglia, mainly in GABA- or glutamate-containing neurons, as well as the presence of TRPV1 receptors in dopaminergic neurons and the identification of CB2 receptors in some neuronal subpopulations within the basal ganglia, explain the powerful motor effects exerted by those cannabinoids that can activate/block these receptors... Collectively, these results suggest that CBD may influence motor activity, in particular vertical activity, and that this effect seems to be dependent on its ability to target the 5-HT1A receptor, a mechanism of action that has been proposed to account for its anti-emetic, anxiolytic and antidepressant effects. )
  • The role of Cannabidiol in Brain / Mental Clarity: Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability. (Epilepsy is the most common neurological disorder, with over 50 million people worldwide affected... Collectively, these results suggest that CBD may influence motor activity, in particular vertical activity, and that this effect seems to be dependent on its ability to target the 5-HT1A receptor, a mechanism of action that has been proposed to account for its anti-emetic, anxiolytic and antidepressant effects. )

Previous article

Cannabidiol, a Cannabis Sativa Constituent, as an Antipsychotic Drug.

Next article

Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects.