What are the properties of Caffeine in supplements?

Caffeine - References & External links

Caffeine

TBS Ingredient ID (TBSI ID):	IS2C8E40
Name
Caffeine Synonyms: 1,3,7-Trimethylxanthine, Thein
Chemical Formula:
C8H10N4O2
Molecular Formula:
Classification Type	Identifier
PubChem CID: U.S. National Library of Medicine (PubChem)	2519
InChI Key: International Chemical Identifier hash (InChIKey) computed from chemical structure using the International Union of Pure and Applied Chemistry (IUPAC) standard	RYYVLZVUVIJVGH-UHFFFAOYSA-N
CAS: A proprietary registry number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society (ACS)	58-08-2
NIST: The National Institute of Standards and Technology (NIST)	58-08-2
ChemIDplus: United States National Library of Medicine - TOXNET (Toxicology Data Network).	58-08-2
EC Number: A seven-digit regulatory identifier currently assigned by the European Chemicals Agency (ECHA) known as a European Community (EC) number	200-362-1
ATC code: WHO ATC Classification System. The Anatomical Therapeutic Chemical (ATC) Classification System is used for the classification of drugs. This pharmaceutical coding system divides drugs into different groups according to the organ or system on which they act and/or their therapeutic and chemical characteristics	N06BC01

The references to scientific articles about Caffeine are not meant to imply that any products treat, cure, or diagnose any disease or human condition. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• The properties of Caffeine for Weight Loss:
  Caffeine isn’t just a great ingredient to reduce fatigue and increase alertness and focus (as would your favorite cup of coffee). It also stimulates thermogenesis, slimming you down by turning up your body’s internal temperature. It can even reduce your appetite, helping you stay on track with your healthy eating choices. Caffeine instantly energizes, increases concentration and improves endurance. It allows you to practice longer and achieve better results.
  • TABRIZI, R.; SANEEI, P.; LANKARANI, K. B.; AKBARI, M.; KOLAHDOOZ, F.; ESMAILLZADEH, A.; NADI-RAVANDI, S.; MAZOOCHI, M.; ASEMI, Z. The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials. Critical reviews in food science and nutrition, 2018, 2018: 1-9. PMID:30335479
  • SMITH, Andrew. Effects of caffeine on human behavior. Food and chemical toxicology, 2002, 40.9: 1243-1255. PMID:12204388
  • GRAHAM, Terry E. Caffeine and exercise: metabolism, endurance and performance. Sports medicine, 2001, 31.11: 785-807. PMID:11583104
  • CAMPBELL, Bill I.; ZITO, G.; COLQUHOUN, R.; MARTINEZ, N.; KENDALL, K.; BUCHANAN, N.; LEHN, M.; JOHNSON, M.; ST LOUIS, C.; SMITH, Y.; CLOER, B.; PINGEL, A. The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females-a randomized, double-blind, placebo-controlled, cross-over trial. Journal of the International Society of Sports Nutrition, 2016, 13.1: 13. PMID:27034624
    CONCLUSIONS:The thermogenic dietary supplement treatment experienced greater elevations in RMR as compared to baseline. Due to the slight elevations in blood pressure, caution should be taken for those with increased risk for hypertension or pre-hypertension. Taken on a daily basis, thermogenic dietary supplementation may increase overall energy expenditure, potentially leading to reductions in fat mass over time.
  • LOPEZ, Hector L.; et al. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. Journal of the International Society of Sports Nutrition, 2013, 10.1: 1-14. PMID:23601452
    Conclusions: METABO administration is a safe and effective adjunct to an eight-week diet and exercise weight loss program by augmenting improvements in body composition, waist and hip girth. Adherence to the eight-week weight loss program also led to beneficial changes in body fat in placebo. Ongoing studies to confirm these results and clarify the mechanisms (i.e., biochemical and neuroendocrine mediators) by which METABO exerts the observed salutary effects are being conducted.
• The properties of Caffeine boosting Brain / Mental Clarity:
  Caffeine: accelerates response time, reduces fatigue, increases physical endurance, helps to increase alertness.
  • BELLO, Marissa L.; et al. The effects of TeaCrine® and caffeine on endurance and cognitive performance during a simulated match in high-level soccer players. Journal of the International Society of Sports Nutrition, 2019, 16.1: 20. PMID:30999897
    CONCLUSIONS: The 27-38% improvements in TTE reflect increased performance capacity that may have important implications for overtime scenarios. These findings suggest TeaCrine® favorably impacts endurance and the combination with caffeine provides greater benefits on cognitive function than either supplement independently.
  • DIETZ, Christina; DEKKER, Matthijs. Effect of Green Tea Phytochemicals on Mood and Cognition. Current pharmaceutical design, 2017, 23.19: 2876-2905. PMID:28056735
    Conclusion: Caffeine was found to mainly improve performance on demanding long-duration cognitive tasks and self-reported alertness, arousal, and vigor. Significant effects already occurred at low doses of 40 mg. L-theanine alone improved self-reported relaxation, tension, and calmness starting at 200 mg. L-theanine and caffeine combined were found to particularly improve performance in attention-switching tasks and alertness, but to a lesser extent than caffeine alone. No conclusive evidence relating to effects induced by EGCG could be given since the amount of intervention studies was limited. These studies provided reliable evidence showing that L-theanine and caffeine have clear beneficial effects on sustained attention, memory, and suppression of distraction. Moreover, L-theanine was found to lead to relaxation by reducing caffeine induced arousal.