Probiotic Bifidobacterium Animalis Subsp. Lactis Bi-07 Alleviates Bacterial Translocation and Ameliorates Microinflammation in Experimental Uraemia.

Wei Meng, et al.
Nephrology, 2014

Abstract

Aim

Uraemia is characterized by intestinal bacterial translocation, which contributes to the development of microinflammation. Probiotics enhance the intestinal barrier and overall health of the host. The present study investigated whether the probiotic Bifidobacterium animalis subsp. lactis Bi-07 alleviates bacterial translocation and ameliorates microinflammation in experimental uraemia.

Methods

Sixty Sprague-Dawley rats were divided into three groups of 20 rats each: the sham group, which underwent only laparotomy; the uraemia group, which underwent 5/6 nephrectomy; and the uraemia + probiotic group, which underwent 5/6 nephrectomy and daily intragastric administration of B. animalis subsp. lactis Bi-07 for 4 weeks. Bacterial translocation was evaluated by polymerase chain reaction amplification of the green fluorescent protein (GFP) gene from oral GFP-labelled Escherichia coli in the peripheral blood, mesenteric lymph nodes, liver, and spleen. Intestinal permeability, plasma inflammatory biomarker levels, and endotoxin levels were measured. Jejunum, ileum, and colon specimens were removed for histological examination.

Results

Uraemic rats exhibited a significantly higher incidence of bacterial translocation (70%) than did sham rats (10%). Probiotic treatment resulted in a decrease in bacterial translocation (20%). Intestinal permeability, inflammatory biomarker levels, and endotoxin levels in uraemic rats were significantly higher than those in the sham group. After treatment with the probiotic, inflammatory biomarker levels significantly decreased. Uraemic rats demonstrated superficial mucosal erosion and inflammatory cell infiltration in the small intestine, and administration of the probiotic alleviated these lesions.

Conclusion

The probiotic B. animalis subsp. lactis Bi-07 alleviate bacterial translocation and ameliorate microinflammation through the recovery of intestinal mucosal integrity.

Keywords

bacterial translocation; intestinal permeability; microinflammation; probiotic; uraemia.

© 2014 Asian Pacific Society of Nephrology.

The best supplements with Bifidobacterium Animalis in Digestive Health category:

• BioDophilus60, Advanced Probiotic Formula, 60 Billion CFU, 60 Capsules (Zahler) - 60 Billion Live & Active CFUS. It contains among others: Bifidobacterium Animalis.
• Gr8-Dophilus, 120 Veg Capsules (Now Foods) - NOW Gr8-Dophilus is a combination of 8 different species of friendly bacteria formulated to support gastrointestinal health and immune system function. It contains among others: Bifidobacterium Animalis.
• Berry Dophilus, Kids, 2 Billion, 120 Chewables (Now Foods) - NOW BerryDophilus provides 2 billion CFU from a combination of 10 clinically validated probiotic bacterial strains designed to support gastrointestinal health and healthy immune system function. It contains among others: Bifidobacterium Animalis.
• 8 Billion Acidophilus & Bifidus, 120 Veg Capsules (Now Foods) - This NOW product has a balanced blend of the two prominent species of resident intestinal bacteria. It contains among others: Bifidobacterium Animalis.
• Woman's Probiotic 20 Billion, 50 Veggie Caps (Now Foods) - Now Women's Probiotic has been specially formulated using three clinically tested probiotic strains to support women's health through every stage of life. It contains among others: Bifidobacterium Animalis.
• Probiotic-10, 100 Billion, 30 Veg Capsules (Now Foods) - Now Probiotic-10 offers a balanced spectrum of live organisms consisting of acid-resistant probiotic bacterial strains that are known to naturally colonize the human GI Tract. It contains among others: Bifidobacterium Animalis.
• Probiotic-10, 50 Billion, 50 Veg Capsules (Now Foods) - NOW Probiotic-10 offers a balanced spectrum of live organisms consisting of acid-resistant probiotic bacterial strains that are known to naturally colonize the human GI tract. It contains among others: Bifidobacterium Animalis.
• Probiotic-10, 25 Billion, 50 Veg Capsules (Now Foods) - NOW Probiotic-10 offers a balanced spectrum of live organisms consisting of acid-resistant probiotic bacterial strains that are known to naturally colonize the human GI tract. It contains among others: Bifidobacterium Animalis.
• Probiotic-10, 25 Billion, 100 Veg Capsules (Now Foods) - Now Probiotic-10 offers a balanced spectrum of live organisms consisting of acid-resistant probiotic bacterial strains that are known to naturally colonize the human GI Tract. It contains among others: Bifidobacterium Animalis.
• Super Bifidophilus - Vitabase Super Bifidophilus is a probiotic. It contains among others: Bifidobacterium Animalis.

Articles similar to "Probiotic Bifidobacterium Animalis Subsp. Lactis Bi-07 Alleviates Bacterial Translocation and Ameliorates Microinflammation in Experimental Uraemia."

• The significance of Bifidobacterium Animalis for Digestive Health: Effect of a Fermented Milk Containing Bifidobacterium Animalis DN-173 010 on the Health-Related Quality of Life and Symptoms in Irritable Bowel Syndrome in Adults in Primary Care: A Multicentre, Randomized, Double-Blind, Controlled Trial. ( Health-related quality of life (HRQoL) has been rarely evaluated as a primary endpoint in the assessment of the effect of probiotics on the irritable bowel syndrome (IBS)... This study suggests a beneficial effect of a probiotic food on discomfort HRQoL score and bloating in constipation-predominant IBS, and on stool frequency in subjects with )
• The role of Bifidobacterium Animalis in Digestive Health: Probiotic Bacteria Lactobacillus Acidophilus NCFM and Bifidobacterium Lactis Bi-07 Versus Placebo for the Symptoms of Bloating in Patients With Functional Bowel Disorders: A Double-Blind Study. ( Recent data suggest a role for the intestinal microbiota in the pathogenesis of functional bowel disorders (FBDs)... L-NCFM and B-LBi07 twice a day improve symptoms of bloating in patients with FBDs. These data supports the role of intestinal bacteria in the pathophysiology of FBD and the role for probiotic bacteria in the management of these disorders. )
• The impact of Bifidobacterium Animalis on Digestive Health: Effects of the Food Manufacturing Chain on the Viability and Functionality of Bifidobacterium Animalis Through Simulated Gastrointestinal Conditions. (The viability and functionality of probiotics may be influenced by industrial production processes resulting in a decrease in probiotic efficiency that benefit the health of humans... L-NCFM and B-LBi07 twice a day improve symptoms of bloating in patients with FBDs. These data supports the role of intestinal bacteria in the pathophysiology of FBD and the role for probiotic bacteria in the management of these disorders. )
• The significance of Bifidobacterium Animalis for Digestive Health: Anti-inflammatory Effect of Multistrain Probiotic Formulation (L. Rhamnosus, B. Lactis, and B. Longum). (Objective: In recent years, a great number of studies have been directed toward the evaluation of gastrointestinal microbiota modulation through the introduction of beneficial microorganisms, also known as probiotics... The transwell model is an intriguing toll approach to studying the human epithelial barrier. )
• The impact of Bifidobacterium Animalis on Digestive Health: Four Weeks of Probiotic Supplementation Reduces GI Symptoms During a Marathon Race. (Purpose: To evaluate the effects of probiotic supplementation on gastrointestinal (GI) symptoms, circulatory markers of GI permeability, damage, and markers of immune response during a marathon race... Probiotics supplementation was associated with a lower incidence and severity of GI symptoms in marathon runners, although the exact mechanisms are yet to be elucidated. Reducing GI symptoms during marathon running may help maintain running pace during the latter stages of racing. )
• The significance of Bifidobacterium Animalis for Digestive Health: Starter Formula Enriched in Prebiotics and Probiotics Ensures Normal Growth of Infants and Promotes Gut Health: A Randomized Clinical Trial. ( Prebiotics and probiotics exert beneficial effects by modulating gut microbiota and immune system... An infant formula enriched with bovine milk-derived oligosaccharide and B. lactis supports normal infant growth, is well tolerated and improves intestinal health markers. No differences in diarrhea and febrile infection incidence were found in the population studied.)
• The role of Bifidobacterium Animalis in Digestive Health: Effect of Inulin on the Human Gut Microbiota: Stimulation of Bifidobacterium Adolescentis and Faecalibacterium Prausnitzii. (Prebiotics are food ingredients that improve health by modulating the colonic microbiota... An infant formula enriched with bovine milk-derived oligosaccharide and B. lactis supports normal infant growth, is well tolerated and improves intestinal health markers. No differences in diarrhea and febrile infection incidence were found in the population studied.)
• The impact of Bifidobacterium Animalis on Digestive Health: Adaptation and Response of Bifidobacterium Animalis Subsp. Lactis to Bile: A Proteomic and Physiological Approach. (Bile salts are natural detergents that facilitate the digestion and absorption of the hydrophobic components of the diet... An infant formula enriched with bovine milk-derived oligosaccharide and B. lactis supports normal infant growth, is well tolerated and improves intestinal health markers. No differences in diarrhea and febrile infection incidence were found in the population studied.)

Previous article

Obesity-associated Gut Microbiota Is Enriched in Lactobacillus Reuteri and Depleted in Bifidobacterium Animalis and Methanobrevibacter Smithii.

Next article

Four Weeks of Probiotic Supplementation Reduces GI Symptoms During a Marathon Race.