Evidence-based Mixture Containing Lactobacillus Strains and Lactoferrin to Prevent Recurrent Bacterial Vaginosis: A Double Blind, Placebo Controlled, Randomised Clinical Trial.

Russo R., Karadja E., De Seta F.
Beneficial microbes, 2019

Abstract

Bacterial vaginosis (BV) is the most common cause of vaginal discomfort in women. It is characterised by abnormal vaginal microbiota with a depletion of lactobacilli and predominance of anaerobic microorganisms, mainly Gardnerella vaginalis and Atopobium vaginae. Although antibiotics represent an effective therapeutic option in the short-term, recurrent infections still remain a serious problem. Nowadays, evidence exists about the efficacy of probiotics for the management of BV. The aim of the current double blind, randomised clinical trial was to assess the efficacy of a probiotic mixture, including Lactobacillus acidophilus GLA-14 and Lactobacillus rhamnosus HN001, in combination with bovine lactoferrin, as adjuvant therapy to metronidazole in women with recurrent BV. In particular, normalisation of Nugent score, remission of symptoms and recurrences during a six-months follow-up were assessed. 48 adult women received metronidazole (500 mg twice daily) for 7 days and randomly assigned to take simultaneously either probiotics plus lactoferrin or placebo (2 capsules/day for 5 days followed by 1 capsule/day for 10 consecutive days; induction phase). The verum or placebo administration (1 capsule/day for 10 consecutive days) was repeated each month (maintenance phase) during the six months of follow-up starting the first day of menstrual cycle since the menstrual blood increases the vaginal pH and contributes to increase the risk of recurrences. The results showed that symptoms (vaginal discharge and itching), Nugent score and recurrence rate were significantly improved by probiotics mixture in association with lactoferrin. This alternative approach may represent a safe and effective remedy for the restoration of healthy vaginal microbiota in preventing recurrent BV.

Keywords

bacterial vaginosis; bovine lactoferrin.

The best supplements with Lactobacillus Rhamnosus or Lactobacillus Acidophilus in Women's Health category:

• Woman's Probiotic 20 Billion, 50 Veggie Caps (Now Foods) - Now Women's Probiotic has been specially formulated using three clinically tested probiotic strains to support women's health through every stage of life. It contains among others: Lactobacillus Rhamnosus, Lactobacillus Acidophilus.

Articles similar to "Evidence-based Mixture Containing Lactobacillus Strains and Lactoferrin to Prevent Recurrent Bacterial Vaginosis: A Double Blind, Placebo Controlled, Randomised Clinical Trial."

• The impact of Lactobacillus Acidophilus on Women's Health: Effects of Probiotics on the Recurrence of Bacterial Vaginosis: A Review. (Objective: Bacterial vaginosis (BV) is a common cause of genital discomfort in women in reproductive ages, which causes many complications... Although the results of different studies are controversial, most studies have been in favor of the probiotics in the prevention or treatment of BV, and no adverse effects have been reported. Therefore, it may be helpful to recommend daily consumption of probiotic products to improve public health among women.)
• The role of Lactobacillus Rhamnosus in Women's Health: Long-term Lactobacillus Rhamnosus BMX 54 Application to Restore a Balanced Vaginal Ecosystem: A Promising Solution Against HPV-infection. ( Over recent years, a growing interest has developed in microbiota and in the concept of maintaining a special balance between Lactobacillus and other bacteria species in order to promote women's well-being... The consistent percentage of clearance of PAP-smear abnormalities and HPV-clearance obtained in long-term treatment group has been interestingly high and encouraging. Obviously, larger and randomized studies are warranted to confirm these encouraging results, but we believe that eubiosis re-establishment is the key to tackle effectively even HPV-infection. )
• The impact of Lactobacillus Rhamnosus on Women's Health: Probiotics in the Prevention of Recurrences of Bacterial Vaginosis. (Context: Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women during their fertile years...)
• The significance of Lactobacillus Rhamnosus for Women's Health: Effect of a Yoghurt Drink Containing Lactobacillus Strains on Bacterial Vaginosis in Women - A Double-Blind, Randomised, Controlled Clinical Pilot Trial. (Bacterial vaginosis (BV) is characterised by a depletion of lactobacilli in favour of an overgrowth of anaerobic bacteria...)
• The significance of Lactobacillus Acidophilus for Women's Health: Effects of Lactobacillus Rhamnosus and Lactobacillus Acidophilus on Bacterial Vaginal Pathogens. (The human vagina is colonized by a variety of microbes...)
• The impact of Lactobacillus Rhamnosus on Women's Health: Restoring Vaginal Microbiota: Biological Control of Bacterial Vaginosis. A Prospective Case-Control Study Using Lactobacillus Rhamnosus BMX 54 as Adjuvant Treatment Against Bacterial Vaginosis. (Purpose: Bacterial vaginosis (BV) is the most prevalent lower genital tract infection in reproductive-age women worldwide... Probiotic supplementation with vaginal Lactobacillus rhamnosus BMX54 seems to be useful in hindering bacteria growth especially after antibiotic therapy; therefore this intervention may be considered a new prophylactic treatment for preventing recurrence of BV, in particular in high-risk patients. )
• The role of Lactobacillus Rhamnosus in Women's Health: Effectiveness of Vaginal Administration of Lactobacillus Rhamnosus Following Conventional Metronidazole Therapy: How to Lower the Rate of Bacterial Vaginosis Recurrences. (Eighty-four patients with bacterial vaginosis diagnosed according to Amsel's criteria were randomized to receive either oral metronidazole 500 mg twice a day for seven days, or one vaginal tablet containing freeze-dried Lactobacillus rhamnosus once a week at bedtime for two months starting one week after the last antibiotic administration... Probiotic supplementation with vaginal Lactobacillus rhamnosus BMX54 seems to be useful in hindering bacteria growth especially after antibiotic therapy; therefore this intervention may be considered a new prophylactic treatment for preventing recurrence of BV, in particular in high-risk patients. )

Previous article

Probiotics in the Prevention of Recurrences of Bacterial Vaginosis.

Next article

Effectiveness of Vaginal Administration of Lactobacillus Rhamnosus Following Conventional Metronidazole Therapy: How to Lower the Rate of Bacterial Vaginosis Recurrences.