Formulations of Dietary Supplements and Herbal Extracts for Relaxation and Anxiolytic Action: Relarian.

Weeks Benjamin
Medical Science Monitor, 2009

Abstract

Dietary supplements are widely used for desired effects on memory, insomnia, mood and anxiety. This review focuses on supplements which have anxiolytic or mild relaxation properties and enhance mood. For example, Kava (Piper methysticum) is reported to have anaxiolytic actions and to reduce tension through skeletal muscle relaxation. Dried passion flower (genus Passiflora) is reported to reduce insomnia and hysteria. Skullcap (genus Scutellaria), hops (Humulus lupulus), lemon balm (Melissa officinalis) and Valerian (Valeriana officinalis) root are all herbs reported as anaxiolytic calming agents. Further, extracts of Magnolia and Phellondendron bark are mild sedatives. Supplements such as gamma-aminobutyric acid (GABA), theanine, tryptophan and 5-hydroxytryptophan (5-HTP) are reported to promote relaxation. In general, these supplements appear to act as GABA receptor agonists or to boost GABA levels, although Kava inhibits both norephinephrine uptake and sodium and potassium channels and 5-HTP may act through elevation of serotonin. While questions remain in the literature regarding the medicinal value of these supplements in treating mood and anxiety disorders, based on cellular and animal studies as well as human clinical trials the literature supports a role for these preparations as useful alternatives in the management of the stress and anxiety of everyday life.

The best supplements with 5-Hydroxytryptophan in Stress / Relaxation category:

• Calming 5-HTP Stress Support, 100 mg, 120 Vegetarian Capsules (Zenwise Health) - Zenwise Health 5-HTP is a dietary supplement that contains 100 mg of 5-HTP (5-Hydroxytryptophan) and 10 mg of Vitamin B6 to support mood and stress levels. It contains among others: 5-Hydroxytryptophan.
• Mood Support with St. John's Wort, 90 Veg Capsules (Now Foods) - NOW Mood Support is a nutritional supplement that has both nutrients and herbal extracts that aid in the support of a healthy nervous system and a positive, balanced mood state. It contains among others: 5-Hydroxytryptophan.

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