Krishnadev Nupura, Meleth Annal D., Chew Emily Y.
Current opinion in ophthalmology, 2010
Abstract
Purpose of review
Age-related macular degeneration (AMD), a leading cause of visual loss in older adults, has limited therapeutic options. This review describes the current literature on the role of nutritional supplementation in primary and secondary prevention of AMD.
Recent findings
Many observational studies have explored the association between diet, nutrient intake, and AMD. In particular, high dietary intakes of omega-3 fatty acids, and macular xanthophylls lutein and zeaxanthin have been associated with a lower risk of prevalent and incident AMD. However, the Age-Related Eye Disease study (AREDS) is the only large-scale randomized controlled clinical trial to show a 25% beneficial effect of nutritional supplementation in reducing the risk progression to advanced AMD in patients with intermediate AMD or with advanced AMD in one eye at 5 years of follow-up. On the basis of the results of AREDS, these patients are recommended to take AREDS formulation of vitamins C, E, beta-carotene, and zinc with copper.
Summary
At the present time, there is insufficient evidence in the literature to recommend routine nutritional supplementation in healthy adults for primary prevention of AMD. However, patients with intermediate risk of AMD or advanced AMD in one eye should consider taking AREDS-type supplements. Observational studies have also suggested benefit from increased dietary intake of macular xanthophylls and omega-3 fatty acids. These are currently being evaluated prospectively in a randomized controlled clinical trial, the AREDS2.
| PMID: | 20216418 |
|---|---|
| DOI: | 10.1097/ICU.0b013e32833866ee |
| PMCID (Free PMC Article): | PMC2909501 |
| Category: | Eye Health |
The best supplements with Zeaxanthin or Lutein in Eye Health category:
- 1MD - VisionMD™ -
VisionMD™ - Complete Vision & Eye Support
VisionMD™ exceeds the National Eye Institute’s extensive eye health nutrient recommendations, based on the comprehensive AREDS 2 & CARMIS clinical studies. It contains among others: Zeaxanthin, Lutein. - Healthy Vision, 60 Vegan Liquid Phyto-Caps (Gaia Herbs) - Purity - Keep it CleanAll products are screened for pesticides, microbes & heavy metals. It contains among others: Lutein.
- Lutein, 10 mg, 120 Softgels (Now Foods) - Lutein is an orange-red carotenoid pigment produced by plants and is present in the diet in colorful fruits and vegetables. It contains among others: Lutein.
- Lutein, Double Strength, 90 Veg Capsules (Now Foods) - Lutein is an orange-red carotenoid pigment produced by plants and is present in the diet in color fruits and vegetables. It contains among others: Zeaxanthin, Lutein.
- Astaxanthin, 10 mg, 60 Softgels (Now Foods) - NOW Astaxanthin is a naturally occurring carotenoid that, due to its unique structure, performs an important role in cellular free radical protection and healthy immune system responses. It contains among others: Lutein.
- Lutein & Zeaxanthin, 60 Softgels (Now Foods) - Lutein and Zeaxanthin are free radical scavenging carotenoid pigments often found together in vegetables. It contains among others: Zeaxanthin, Lutein.
Articles similar to "Nutritional supplements for age-related macular degeneration."
- The significance of Lutein for Eye Health: Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. (The human macula uniquely concentrates three carotenoids: lutein, zeaxanthin, and meso-zeaxanthin...)
- The role of Lutein in Eye Health: The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. (OBJECTIVE: To evaluate the relationship of dietary carotenoids, vitamin A, alpha-tocopherol, and vitamin C with prevalent age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS)... Higher dietary intake of lutein/zeaxanthin was independently associated with decreased likelihood of having neovascular AMD, geographic atrophy, and large or extensive intermediate drusen.)
- The impact of Lutein on Eye Health: Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration. (PURPOSE: To evaluate the effects of lutein and zeaxanthin on visual function in randomized controlled trials (RCTs) of AMD patients... Lutein and zeaxanthin supplementation is a safe strategy for improving visual performance of AMD patients, which mainly showed in a dose-response relationship. )
- The role of Lutein in Eye Health: Role of lutein supplementation in the management of age-related macular degeneration: meta-analysis of randomized controlled trials. (OBJECTIVE: The conduct of this meta-analysis aimed at examining the individual role of lutein as a dietary supplement in improving conditions of age-related macular degeneration (AMD) from the data generated from randomized controlled trials (RCTs)... A statistically highly significant effect of lutein supplementation has been observed for improving the MPOD, whereas the improvement in VA was milder. A daily dose of 10 mg was found as effective as higher doses in this meta-analysis. However, the number of input studies is not adequate for conclusive evidence. )
- The impact of Lutein on Eye Health: Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. (Lutein and zeaxanthin are thought to decrease the incidence of age-related macular degeneration (AMD); however, findings have been inconsistent... A statistically highly significant effect of lutein supplementation has been observed for improving the MPOD, whereas the improvement in VA was milder. A daily dose of 10 mg was found as effective as higher doses in this meta-analysis. However, the number of input studies is not adequate for conclusive evidence. )
- The role of Lutein in Eye Health: A Mechanistic Review of β-Carotene, Lutein, and Zeaxanthin in Eye Health and Disease. (Carotenoids are natural lipid-soluble antioxidants abundantly found as colorful pigments in fruits and vegetables... A statistically highly significant effect of lutein supplementation has been observed for improving the MPOD, whereas the improvement in VA was milder. A daily dose of 10 mg was found as effective as higher doses in this meta-analysis. However, the number of input studies is not adequate for conclusive evidence. )