Stone Michael, Martyn Lisa, Weaver Connie
Nutrients, 2016
Abstract
Potassium is an essential nutrient. It is the most abundant cation in intracellular fluid where it plays a key role in maintaining cell function. The gradient of potassium across the cell membrane determines cellular membrane potential, which is maintained in large part by the ubiquitous ion channel the sodium-potassium (Na+-K+) ATPase pump. Approximately 90% of potassium consumed (60-100 mEq) is lost in the urine, with the other 10% excreted in the stool, and a very small amount lost in sweat. Little is known about the bioavailability of potassium, especially from dietary sources. Less is understood on how bioavailability may affect health outcomes. Hypertension (HTN) is the leading cause of cardiovascular disease (CVD) and a major financial burden ($50.6 billion) to the US public health system, and has a significant impact on all-cause morbidity and mortality worldwide. The relationship between increased potassium supplementation and a decrease in HTN is relatively well understood, but the effect of increased potassium intake from dietary sources on blood pressure overall is less clear. In addition, treatment options for hypertensive individuals (e.g., thiazide diuretics) may further compound chronic disease risk via impairments in potassium utilization and glucose control. Understanding potassium bioavailability from various sources may help to reveal how specific compounds and tissues influence potassium movement, and further the understanding of its role in health.
Keywords
bioavailability; diabetes; glucose control; hypertension; potassium
| PMID: | 27455317 |
|---|---|
| Category: | General properties of Potassium |
| Category: | General properties of Potassium Citrate |
| Category: | General properties of Potassium Chloride |
| Category: | Minerals |
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Articles similar to "Potassium intake, bioavailability, hypertension, and glucose control."
- The properties of Potassium: Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trials. (IMPORTANCE: Increased dietary potassium intake is thought to be associated with low blood pressure (BP)... Our findings indicated that potassium supplementation is a safe medication with no important adverse effects that has a modest but significant impact BP and may be recommended as an adjuvant antihypertensive agent for patients with essential hypertension.)
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- The significance of Potassium Chloride for Minerals: Potassium chloride supplementation diminishes platelet reactivity in humans. (The prevalence of occlusive stroke is inversely correlated with potassium intake... Potassium supplementation in hypertensives was generally associated with decreased blood pressure, particularly in high sodium consumers, subjects not on hypertensive drug treatment, and those in the lowest category of potassium intake. An adequate dietary intake of potassium, in the order of 90mmol/day, should be achieved for blood pressure control. )
- The role of Potassium Chloride in Minerals: Effect of short-term supplementation of potassium chloride and potassium citrate on blood pressure in hypertensives. (Randomized trials have shown that increasing potassium intake lowers blood pressure... Potassium supplementation in hypertensives was generally associated with decreased blood pressure, particularly in high sodium consumers, subjects not on hypertensive drug treatment, and those in the lowest category of potassium intake. An adequate dietary intake of potassium, in the order of 90mmol/day, should be achieved for blood pressure control. )
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