Topo Enza, et al.
Reproductive Biology and Endocrinology, 2009
Abstract
Background
D-aspartic acid is an amino acid present in neuroendocrine tissues of invertebrates and vertebrates, including rats and humans. Here we investigated the effect of this amino acid on the release of LH and testosterone in the serum of humans and rats. Furthermore, we investigated the role of D-aspartate in the synthesis of LH and testosterone in the pituitary and testes of rats, and the molecular mechanisms by which this amino acid triggers its action.
Methods
For humans: A group of 23 men were given a daily dose of D-aspartate (DADAVIT) for 12 days, whereas another group of 20 men were given a placebo. For rats: A group of 10 rats drank a solution of either 20 mM D-aspartate or a placebo for 12 days. Then LH and testosterone accumulation was determined in the serum and D-aspartate accumulation in tissues. The effects of D-aspartate on the synthesis of LH and testosterone were gauged on isolated rat pituitary and Leydig cells. Tissues were incubated with D-aspartate, and then the concentration (synthesis) of LH and cGMP in the pituitary and of testosterone and cAMP in the Leydig cells was determined.
Results
In humans and rats, sodium D-aspartate induces an enhancement of LH and testosterone release. In the rat pituitary, sodium D-aspartate increases the release and synthesis of LH through the involvement of cGMP as a second messenger, whereas in rat testis Leydig cells, it increases the synthesis and release of testosterone and cAMP is implicated as second messenger. In the pituitary and in testes D-Asp is synthesized by a D-aspartate racemase which convert L-Asp into D-Asp. The pituitary and testes possesses a high capacity to trapping circulating D-Asp from hexogen or endogen sources.
Conclusion
D-aspartic acid is a physiological amino acid occurring principally in the pituitary gland and testes and has a role in the regulation of the release and synthesis of LH and testosterone in humans and rats.
| PMID: | 19860889 |
|---|---|
| Category: | Sports Nutrition |
The best supplements with D-Aspartic Acid in Sports Nutrition category:
- Testo Prime - TestoPrime is an all-natural testosterone support that can help any man take control of his youthful vitality with a flood of new and natural testosterone. It contains among others: D-Aspartic Acid.
- TestoGen - Natural Testosterone Booster Amazing Results. It contains among others: D-Aspartic Acid.
- Somatodrol - To gain real muscle your body needs more testosterone and HGH. It contains among others: D-Aspartic Acid.
Articles similar to "The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats."
- The significance of D-Aspartic Acid for Sports Nutrition: The putative effects of D-Aspartic acid on blood testosterone levels: A systematic review. ( D-Aspartic acid (D-Asp) is in invertebrate and vertebrate neuroendocrine tissues, where it carries out important physiological functions... There is an urgent need for more and well-designed human clinical trials with larger sample sizes and longer duration to investigate putative effects of D-Asp on testosterone concentrations. )
Previous article
Next article
Functionalized poly (3-hydroxybutyric acid) bodies as new in vitro biocatalysts.