Roshanzamir Farzad, Safavi Seyyed Morteza
International Journal of Reproductive BioMedicine, 2017
Abstract
Background
D-Aspartic acid (D-Asp) is in invertebrate and vertebrate neuroendocrine tissues, where it carries out important physiological functions. Recently, it has been reported that D-Asp is involved in the synthesis and release of testosterone and is assumed can be used as a testosterone booster for infertile men, and by athletes to increase muscle mass and strength.
Objective
The aim of this review is to summarize available evidence related to the effects of D-Asp on serum testosterone levels.
Materials and Methods
We conducted a systematic review of all type studies, which evaluated the effect of the D-Asp on blood testosterone including published papers until October 2015, using PubMed, ISI Web of Science, ProQuest and Scopus database.
Results
With 396 retrieved records, 23 animal studies and 4 human studies were included. In vivo and in vitro animal studies revealed the effect of D-Asp depending on species, sex and organ-specific. Our results showed that exogenous D-Asp enhances testosterone levels in male animal's studies, whereas studies in human yielded inconsistent results. The evidence for this association in man is still sparse, mostly because of limited number and poor quality studies.
Conclusion
There is an urgent need for more and well-designed human clinical trials with larger sample sizes and longer duration to investigate putative effects of D-Asp on testosterone concentrations.
Keywords
D-Aspartic acid; Systematic review; Testosterone
| PMID: | 28280794 |
|---|---|
| Category: | Sports Nutrition |
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D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role.