Calabrese Carlo, Gregory W. L., Leo M., Kraemer D., Bone K., Oken B.
The journal of alternative and complementary medicine, 2008
Abstract
Objectives
Study aims were to evaluate effects of Bacopa monnieri whole plant standardized dry extract on cognitive function and affect and its safety and tolerability in healthy elderly study participants.
Design
The study was a randomized, double-blind, placebo-controlled clinical trial with a placebo run-in of 6 weeks and a treatment period of 12 weeks.
Setting / Location
Volunteers were recruited from the community to a clinic in Portland, Oregon by public notification.
Subjects
Fifty-four (54) participants, 65 or older (mean 73.5 years), without clinical signs of dementia, were recruited and randomized to Bacopa or placebo. Forty-eight (48) completed the study with 24 in each group.
Interventions
Standardized B. monnieri extract 300 mg/day or a similar placebo tablet orally for 12 weeks.
Outcome measures
The primary outcome variable was the delayed recall score from the Rey Auditory Verbal Learning Test (AVLT). Other cognitive measures were the Stroop Task assessing the ability to ignore irrelevant information, the Divided Attention Task (DAT), and the Wechsler Adult Intelligence Scale (WAIS) letter-digit test of immediate working memory. Affective measures were the State-Trait Anxiety Inventory, Center for Epidemiologic Studies Depression scale (CESD)-10 depression scale, and the Profile of Mood States. Vital signs were also monitored.
Results
Controlling for baseline cognitive deficit using the Blessed Orientation-Memory-Concentration test, Bacopa participants had enhanced AVLT delayed word recall memory scores relative to placebo. Stroop results were similarly significant, with the Bacopa group improving and the placebo group unchanged. CESD-10 depression scores, combined state plus trait anxiety scores, and heart rate decreased over time for the Bacopa group but increased for the placebo group. No effects were found on the DAT, WAIS digit task, mood, or blood pressure. The dose was well tolerated with few adverse events (Bacopa n = 9, placebo n = 10), primarily stomach upset.
Conclusions
This study provides further evidence that B. monnieri has potential for safely enhancing cognitive performance in the aging.
| PMID: | 18611150 |
|---|---|
| Category: | Brain / Mental Clarity |
The best supplements with Bacopa Monnieri in Brain / Mental Clarity category:
- Brain Actives - Brain Actives is a top quality food supplement with ingredients that will bring your brain to its peak performance without causing any harm. It contains among others: Bacopa Monnieri.
- Pure Nootropics BaCognize® Bacopa Monnieri Capsules - Bacognize® has been clinically tested in humans and has strong scientific evidence to support its benefits. It contains among others: Bacopa Monnieri.
- NooCube - NooCube is a synergistic blend of nootropics which helps support and enhance your focus, mental speed and memory. It contains among others: Bacopa Monnieri.
- Brain Pill - „An amazing new product that supports your brain health and has the potential to change your life returning laser-sharp mental clarity” - Dr Dave David, a surgeon and physician for more than 37 years. It contains among others: Bacopa Monnieri.
Articles similar to "Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial."
- The significance of Bacopa Monnieri for Brain / Mental Clarity: Cognitive training and Bacopa monnieri: Evidence for a combined intervention to alleviate age associated cognitive decline. (As the elderly population grows the impact of age associated cognitive decline as well as neurodegenerative diseases such as Alzheimer's disease and dementia will increase...)
- The role of Bacopa Monnieri in Brain / Mental Clarity: Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. (OBJECTIVE: The objective of this study was to investigate the effectiveness of Bacopa monnieri Linn... Bacopa significantly improved memory acquisition and retention in healthy older Australians. This concurs with previous findings and traditional use. Bacopa caused GIT side-effects of increased stool frequency, abdominal cramps, and nausea.)
- The impact of Bacopa Monnieri on Brain / Mental Clarity: Chronic effects of Brahmi (Bacopa monnieri) on human memory. (A study is reported on the effects of Brahmi (Bacopa monnieri) on human memory... Bacopa significantly improved memory acquisition and retention in healthy older Australians. This concurs with previous findings and traditional use. Bacopa caused GIT side-effects of increased stool frequency, abdominal cramps, and nausea.)
- The significance of Bacopa Monnieri for Brain / Mental Clarity: Effects of 12-Week Bacopa monnieri Consumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers. (At present, the scientific evidence concerning the effect of Bacopa monnieri on brain activity together with working memory is less available... Bacopa significantly improved memory acquisition and retention in healthy older Australians. This concurs with previous findings and traditional use. Bacopa caused GIT side-effects of increased stool frequency, abdominal cramps, and nausea.)
- The impact of Bacopa Monnieri on Brain / Mental Clarity: Efficacy of Standardized Extract of Bacopa monnieri (Bacognize®) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial. (Rationale... Bacopa significantly improved memory acquisition and retention in healthy older Australians. This concurs with previous findings and traditional use. Bacopa caused GIT side-effects of increased stool frequency, abdominal cramps, and nausea.)
- The significance of Bacopa Monnieri for Brain / Mental Clarity: Sustained cognitive effects and safety of HPLC-standardized Bacopa monnieri extract: a randomized, placebo controlled clinical trial. (Bacopa monnieri is an adaptogenic herb used since time immemorial as an Ayurvedic rasayana... Bacopa significantly improved memory acquisition and retention in healthy older Australians. This concurs with previous findings and traditional use. Bacopa caused GIT side-effects of increased stool frequency, abdominal cramps, and nausea.)
- The role of Bacopa Monnieri in Brain / Mental Clarity: Exploring the Role of “Brahmi” (Bacopa monnieri and Centella asiatica) in Brain Function and Therapy. (It has been envisaged that in this century, disorders of the central nervous system will have a significant bearing on the healthcare concerns of the human population worldwide... Bacopa significantly improved memory acquisition and retention in healthy older Australians. This concurs with previous findings and traditional use. Bacopa caused GIT side-effects of increased stool frequency, abdominal cramps, and nausea.)