Izquierdo Jorge-Hernán, et al.
Reumatología Clínica (English Edition), 2014
Abstract
Calcium (Ca²⁺) is an important cation able to function as a second messenger in different cells of the immune system, particularly in B and T lymphocytes, macrophages and mastocytes, among others. Recent discoveries related to the entry of Ca²⁺ through the store-operated calcium entry (SOCE) has opened a new investigation area about the cell destiny regulated by Ca²⁺ especially in B and T lymphocytes. SOCE acts through calcium-release-activated calcium (CRAC) channels. The function of CRAC depends of two recently discovered regulators: the Ca²⁺ sensor in the endoplasmic reticulum or stromal interaction molecule (STIM-1) and one subunit of CRAC channels called Orai1. This review focuses on the role of Ca²⁺ signals in B and T lymphocytes functions, the signalling pathways leading to Ca²⁺ influx, and the relationship between Ca²⁺ signals and autoimmune diseases.
Keywords
Autoimmune diseases; B lymphocyte; Calcio; Calcium signals; Calcium-release-activated calcium; Enfermedades autoinmunes; Linfocito B; Linfocito T; Orai1; Store-operated calcium entry; Stromal interaction molecule; T lymphocyte.
Copyright © 2013 Elsevier España, S.L. All rights reserved.
| PMID: | 24001934 |
|---|---|
| DOI: | 10.1016/j.reuma.2013.05.008 |
| Category: | Immune |
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