Pelletier Lucette, Savignac Magali
Current opinion in immunology, 2018
Abstract
Allergic asthma is a complex disease, often characterized by an inappropriate Th2 response to normally harmless allergens. Epithelial cells damaged or activated by the allergen produce IL-33, TSLP and IL-25, activating ILC2 and dendritic cells. The latter migrate into lymph nodes where they induce Th2-cell commitment. Th2 and other type 2 innate inflammatory cells trigger inflammation and airway hyper-reactivity. The toolbox consisting of the ion channels varies from one cellular type to another and depends on its activation state, offering the possibility to design novel drugs in the field of allergy. We will discuss about some channels as calcium, nonselective cation, potassium and chloride channels that appear as good candidates in allergy.
Copyright © 2018 Elsevier Ltd. All rights reserved.
| PMID: | 29704811 |
|---|---|
| DOI: | 10.1016/j.coi.2018.04.006 |
| Category: | Allergy / Immune |
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