Pusceddu Irene, et al.
European journal of nutrition, 2019
Abstract
Purpose
Short telomeres and B vitamin deficiencies have been proposed as risk factors for age-related diseases and mortality that interact through oxidative stress and inflammation. However, available data to support this concept are insufficient. We aimed to investigate the predictive role of B vitamins and homocysteine (HCY) for mortality in cardiovascular patients. We explored potential relationships between HCY, B vitamins, relative telomere length (RTL), and indices of inflammation.
Methods
Vitamin B6, HCY, interleukin-6 (IL-6), high-sensitive-C-reactive protein (hs-CRP), and RTL were measured in participants of the Ludwigshafen Risk and Cardiovascular Health Study. Death events were recorded over a median follow-up of 9.9 years.
Results
All-cause mortality increased with higher concentrations of HCY and lower vitamin B6. Patients in the 4th quartile of HCY and vitamin B6 had hazard ratios (HR) for all-cause mortality of 2.77 (95% CI 2.28-3.37) and 0.41(95% CI 0.33-0.49), respectively, and for cardiovascular mortality of 2.78 (95% CI 2.29-3.39) and 0.40 (95% CI 0.33-0.49), respectively, compared to those in the 1st quartile. Multiple adjustments for confounders did not change these results. HCY and vitamin B6 correlated with age-corrected RTL (r = - 0.086, p < 0.001; r = 0.04, p = 0.031, respectively), IL-6 (r = 0.148, p < 0.001; r = - 0.249, p < 0.001, respectively), and hs-CRP (r = 0.101, p < 0.001; r = - 0.320, p < 0.001, respectively). Subjects with the longest telomeres had a significantly higher concentration of vitamin B6, but lower concentrations of HCY, IL-6, and hs-CRP. Multiple regression analyses identified HCY as an independent negative predictor of age-corrected RTL.
Conclusions
In conclusion, hyperhomocysteinemia and vitamin B6 deficiency are risk factors for death from any cause. Hyperhomocysteinemia and vitamin B6 deficiency correlate with increased mortality. This correlation might, at least partially, be explained by accelerated telomere shortening induced by oxidative stress and systemic inflammation in these circumstances.
Keywords
Homocysteine; Inflammation; Mortality; Telomere length; Vitamin B6.
| PMID: | 31129702 |
|---|---|
| DOI: | 10.1007/s00394-019-01993-8 |
| Category: | Cardiovascular Support |
The best supplements with Pyridoxine in Cardiovascular Support category:
- B-Complex "100", 100 Vegetable Capsules (Solgar) - Each required nutrient in the Vitamin B Complex performs a unique role in maintaining proper metabolic functioning, while nutritionally supporting the body during the occasional stress of daily living. It contains among others: Pyridoxine.
- B-6, 50 mg, 100 Tablets (Now Foods) - Vitamin B6 is a cofactor in numerous enzymatic reactions and is required for the metabolism of fats, carbohydrates, and proteins. It contains among others: Pyridoxine.
- Brain Actives - Brain Actives is a top quality food supplement with ingredients that will bring your brain to its peak performance without causing any harm. It contains among others: Pyridoxine.
- Vitabase - Enfūz (Advanced) - Enfūz Advanced is a complete nutritional supplement program designed to meet your basic nutritional needs. It contains among others: Pyridoxine.
Articles similar to "Subclinical Inflammation, Telomere Shortening, Homocysteine, Vitamin B6, and Mortality: The Ludwigshafen Risk and Cardiovascular Health Study."
- The significance of Pyridoxine for Cardiovascular Support: Vitamin B6 and Cardiovascular Disease. (While overt vitamin B6 deficiency is not a frequent finding nowadays in medical practice, evidence suggests that insufficiency of this vitamin is rather widespread in a quite large portion of the population such as the elderly or in not unusual conditions such as that of alcohol addiction...)
- The role of Pyridoxine in Cardiovascular Support: Dietary Vitamin B 6 Intake Associated With a Decreased Risk of Cardiovascular Disease: A Prospective Cohort Study. (Although the biological mechanisms underlying the beneficial effects of vitamin B6 on cardiovascular disease (CVD) have been reported on, epidemiological studies have yielded controversial results, and data on the Korean population are limited...)
- The impact of Pyridoxine on Cardiovascular Support: Vitamin B6: A Challenging Link Between Nutrition and Inflammation in CVD. (The objective of the present review is to highlight the relationship between low vitamin B6 status and CVD through its link with inflammation...)