Kolodziej Herbert
Pharmaceuticals, 2011
Abstract
Pelargonium species contribute significantly to the health care of a large population in the Southern African region, as part of a long-standing medical system intimately linked to traditional healing practices. Most notably, extracts of the roots of P. sidoides have commonly been applied for the treatment of dysentery and diarrhoea but only occasionally for respiratory complaints. Clinical trials have shown that a modern aqueous-ethanolic formulation of P. sidoides extracts (EPs® 7630) is an efficacious treatment for disorders of the respiratory tract, for example bronchitis and sinusitis. It should be noted that EPs® 7630 is the most widely investigated extract and therefore is the focus of this review. In order to provide a rationale for its therapeutic activity extracts have been evaluated for antibacterial activity and for their effects on non-specific immune functions. Only moderate direct antibacterial capabilities against a spectrum of bacteria, including Mycobacteria strains, have been noted. In contrast, a large body of in vitro studies has provided convincing evidence for an anti-infective principle associated with activation of the non-specific immune system. Interestingly, significant inhibition of interaction between bacteria and host cells, a key to the pathogenesis of respiratory tract infections, has emerged from recent studies. In addition, antiviral effects have been demonstrated, including inhibition of the replication of respiratory viruses and the enzymes haemagglutinin and neuraminidase. Besides, an increase of cilliary beat frequency of respiratory cells may contribute to the beneficial effects of P. sidoides extracts. This example provides a compelling argument for continuing the exploration of Nature and traditional medical systems as a source of therapeutically useful herbal medicines.
Keywords
Pelargonium sidoides; antibacterial; antiviral; immunomodulation.
| PMID: | 27721327 |
|---|---|
| PMCID (Free PMC Article): | PMC4060126 |
| DOI: | 10.3390/ph4101295 |
| Category: | Immune |
Articles similar to "Antimicrobial, Antiviral and Immunomodulatory Activity Studies of Pelargonium Sidoides (EPs ® 7630) in the Context of Health Promotion."
- The significance of Pelargonium Sidoides for Immune: In Vitro Evaluation of Antibacterial and Immunomodulatory Activities of Pelargonium Reniforme, Pelargonium Sidoides and the Related Herbal Drug Preparation EPs® 7630. (The importance of Pelargonium species, most notably Pelargonium reniforme and Pelargonium sidoides, in traditional medicine in the Southern African region is well documented...)
- The role of Pelargonium Sidoides in Immune: Pelargonium Sidoides Extract for Treating Acute Respiratory Tract Infections. ( Pelargonium sidoides (P... P. sidoides may be effective in alleviating symptoms of acute rhinosinusitis and the common cold in adults, but doubt exists. It may be effective in relieving symptoms in acute bronchitis in adults and children, and sinusitis in adults. The overall quality of the evidence was considered low for main outcomes in acute bronchitis in children and adults, and very low for acute sinusitis and the common cold. Reliable data on treatment for other ARIs were not identified.)
- The impact of Pelargonium Sidoides on Immune: Investigation of the Influence of EPs® 7630, a Herbal Drug Preparation From Pelargonium Sidoides, on Replication of a Broad Panel of Respiratory Viruses. (The Pelargonium sidoides extract EPs® 7630 is an approved drug for the treatment of acute bronchitis in Germany... P. sidoides may be effective in alleviating symptoms of acute rhinosinusitis and the common cold in adults, but doubt exists. It may be effective in relieving symptoms in acute bronchitis in adults and children, and sinusitis in adults. The overall quality of the evidence was considered low for main outcomes in acute bronchitis in children and adults, and very low for acute sinusitis and the common cold. Reliable data on treatment for other ARIs were not identified.)
- The significance of Pelargonium Sidoides for Immune: EPs® 7630 (Umckaloabo®), an Extract From Pelargonium Sidoides Roots, Exerts Anti-Influenza Virus Activity in Vitro and in Vivo. (A prodelphinidin-rich extract from Pelargonium sidoides DC, EPs® 7630 (Umckaloabo®), which is licensed to treat respiratory tract infections such as acute bronchitis, was investigated for its antiviral effects... P. sidoides may be effective in alleviating symptoms of acute rhinosinusitis and the common cold in adults, but doubt exists. It may be effective in relieving symptoms in acute bronchitis in adults and children, and sinusitis in adults. The overall quality of the evidence was considered low for main outcomes in acute bronchitis in children and adults, and very low for acute sinusitis and the common cold. Reliable data on treatment for other ARIs were not identified.)
- The role of Pelargonium Sidoides in Immune: Anti-infective Activities of Pelargonium Sidoides (EPS® 7630): Effects of Induced NO Production on Leishmania Major in Infected Macrophages and Antiviral Effects as Assessed in a Fibroblast-Virus Protection Assay. (EPs® 7630 is an aqueous-ethanolic extract of the roots of Pelargonium sidoides, employed in the treatment of upper respiratory tract infections... P. sidoides may be effective in alleviating symptoms of acute rhinosinusitis and the common cold in adults, but doubt exists. It may be effective in relieving symptoms in acute bronchitis in adults and children, and sinusitis in adults. The overall quality of the evidence was considered low for main outcomes in acute bronchitis in children and adults, and very low for acute sinusitis and the common cold. Reliable data on treatment for other ARIs were not identified.)
- The significance of Pelargonium Sidoides for Immune: Use of Plant Extracts as an Efficient Alternative Therapy of Respiratory Tract Infections. (Medicinal plants are advantageously used in the treatment of respiratory tract diseases... P. sidoides may be effective in alleviating symptoms of acute rhinosinusitis and the common cold in adults, but doubt exists. It may be effective in relieving symptoms in acute bronchitis in adults and children, and sinusitis in adults. The overall quality of the evidence was considered low for main outcomes in acute bronchitis in children and adults, and very low for acute sinusitis and the common cold. Reliable data on treatment for other ARIs were not identified.)
Previous article
Next article
Use of Plant Extracts as an Efficient Alternative Therapy of Respiratory Tract Infections.