What are the properties of Umckaloabo in supplements?

Umckaloabo - References & External links

Umckaloabo (Pelargonium Sidoides)

The references to scientific articles about Umckaloabo are not meant to imply that any products treat, cure, or diagnose any disease or human condition. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• The general properties of Umckaloabo:
  • MOYO, Mack; VAN STADEN, Johannes. Medicinal Properties and Conservation of Pelargonium Sidoides DC. Journal of ethnopharmacology, 2014, 152.2: 243-255. PMID:24463034
    Conclusions: Pharmacological data reported in literature suggest that Pelargonium sidoides shows a beneficial effect in the treatment of respiratory tract infections. However, more studies are required to elucidate the mode of action of the active constituents exhibited in the treatment of respiratory tract infections and other health conditions caused by microbial attack. Furthermore, the pharmacological usefulness of Pelargonium sidoides must take cognisance of the broader context involving the need for conservation-friendly approaches in its utilisation. In this regard, plant biotechnology applications can play a meaningful role in a holistic conservation strategy.
• The properties of Umckaloabo enhancing immunity:
  Pelargonium sidoides is a medical herb and respective extracts are used very frequently for the treatment of respiratory tract infections.
  • WITTE, Katrin; et al. The Pelargonium Sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes. PloS one, 2015, 10.9: . PMID:26406906
  • TAHAN, Fulya; YAMAN, Melih. Can the Pelargonium Sidoides Root Extract EPs® 7630 Prevent Asthma Attacks During Viral Infections of the Upper Respiratory Tract in Children?. Phytomedicine, 2013, 20.2: 148-150. PMID:23142309
• Influence of Umckaloabo on the Immune Response:
  • KOLODZIEJ, Herbert; KIDERLEN, Albrecht F. In Vitro Evaluation of Antibacterial and Immunomodulatory Activities of Pelargonium Reniforme, Pelargonium Sidoides and the Related Herbal Drug Preparation EPs® 7630. Phytomedicine, 2007, 14: 18-26. PMID:17188480
  • TIMMER, Antje; et al. Pelargonium Sidoides Extract for Treating Acute Respiratory Tract Infections. Cochrane Database of Systematic Reviews, 2013, 10: CD006323. PMID:24146345
    conclusions: P. sidoides may be effective in alleviating symptoms of acute rhinosinusitis and the common cold in adults, but doubt exists. It may be effective in relieving symptoms in acute bronchitis in adults and children, and sinusitis in adults. The overall quality of the evidence was considered low for main outcomes in acute bronchitis in children and adults, and very low for acute sinusitis and the common cold. Reliable data on treatment for other ARIs were not identified.
  • MICHAELIS, Martin; DOERR, Hans Wilhelm; CINATL JR, Jindrich. Investigation of the Influence of EPs® 7630, a Herbal Drug Preparation From Pelargonium Sidoides, on Replication of a Broad Panel of Respiratory Viruses. Phytomedicine, 2011, 18.5: 384-386. PMID:21036571
  • THEISEN, Linda L.; MULLER, Claude P. EPs® 7630 (Umckaloabo®), an Extract From Pelargonium Sidoides Roots, Exerts Anti-Influenza Virus Activity in Vitro and in Vivo. Antiviral research, 2012, 94.2: 147-156. PMID:22475498
  • THäLE, Carsten; KIDERLEN, Albrecht Ferdinand; KOLODZIEJ, Herbert. Anti-infective Activities of Pelargonium Sidoides (EPS® 7630): Effects of Induced NO Production on Leishmania Major in Infected Macrophages and Antiviral Effects as Assessed in a Fibroblast-Virus Protection Assay. Planta medica, 2011, 77.07: 718-725. PMID:21104606
  • KOLODZIEJ, Herbert. Antimicrobial, Antiviral and Immunomodulatory Activity Studies of Pelargonium Sidoides (EPs ® 7630) in the Context of Health Promotion. Pharmaceuticals, 2011, 4.10: 1295-1314. PMID:27721327
  • ŠMEJKAL, Karel; RJAšKOVá, Veronika. Use of Plant Extracts as an Efficient Alternative Therapy of Respiratory Tract Infections. Ceska a Slovenska farmacie: casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2016, 65.4: 139-160. PMID:27860473
• The properties of Umckaloabo preventing Cold / Flu:
  It significantly reduces the severity of symptoms and shortens the duration of the common cold.
  • SAVICKIENE, Nijole; et al. Efficacy of Proanthocyanidins From Pelargonium sidoides Root Extract in Reducing P. gingivalis Viability While Preserving Oral Commensal S. salivarius. Materials, 2018, 11.9: 1499. PMID:30135370
  • JEKABSONE, Aiste; et al. Investigation of Antibacterial and Antiinflammatory Activities of Proanthocyanidins From Pelargonium sidoides DC Root Extract. Nutrients, 2019, 11.11: 2829. PMID:31752295
  • WITTE, Katrin; et al. The Pelargonium Sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes. PloS one, 2015, 10.9: . PMID:26406906
  • PATIROGLU, Turkan; et al. The Efficacy of Pelargonium Sidoides in the Treatment of Upper Respiratory Tract Infections in Children With Transient Hypogammaglobulinemia of Infancy. Phytomedicine, 2012, 19.11: 958-961. PMID:22809962
  • LIZOGUB, Viktor G.; RILEY, David S.; HEGER, Marianne. Efficacy of a Pelargonium Sidoides Preparation in Patients With the Common Cold: A Randomized, Double Blind, Placebo-Controlled Clinical Trial. Explore, 2007, 3.6: 573-584. PMID:18005909
    Conclusions: EPs represents an effective treatment of the common cold. It significantly reduces the severity of symptoms and shortens the duration of the common cold compared with placebo. The herbal drug is well tolerated.
  • MATTHYS, H.; et al. Efficacy and Tolerability of EPs 7630 Tablets in Patients With Acute Bronchitis: A Randomised, Double-Blind, Placebo-Controlled Dose-Finding Study With a Herbal Drug Preparation From Pelargonium Sidoides. Current medical research and opinion, 2010, 26.6: 1413-1422. PMID:20387996
    Conclusion: This study demonstrated statistically significant and clinically relevant superiority of all three tested dosages of EPs 7630 over placebo. All dosages of EPs 7630 were well-tolerated. Taking into account both efficacy and safety, the results of this study indicate that the 20 mg tablets of EPs 7630 taken three times daily constitute the optimal dose with respect to the benefit-risk ratio.
  • CHUCHALIN, A. G.; BERMAN, B.; LEHMACHER, W. Treatment of Acute Bronchitis in Adults With a Pelargonium Sidoides Preparation (EPs® 7630): A Randomized, Double-Blind, Placebo-Controlled Trial. Explore, 2005, 1.6: 437-445. PMID:16781588
    Conclusions: EPs 7630 was superior in efficacy compared with placebo in the treatment of adults with acute bronchitis. It may therefore offer an effective alternative for acute bronchitis unless antibiotics are clearly indicated.