What are the properties of Vitamin B3 in supplements?

The Supplements with Vitamin B3The Supplements with Vitamin B3

The properties of Vitamin B3

Vitamin B3 is a vitamin that includes three forms: nicotinamide (niacinamide), niacin (nicotinic acid), and nicotinamide riboside. All three forms of vitamin B3 are converted within the body to nicotinamide adenine dinucleotide (NAD). NAD is required for human life and people are unable to make it within their bodies without one of the vitamin B3 or tryptophan. The group is also occasionally referred to as vitamin B3 complex.

Recommended Daily Allowance

Vitamin B3 – Recommended Daily Allowance: 16/14 mg.

Symptoms of Deficiency

Pellagra: dermatitis/photo dermatitis, alopecia, muscle weakness, twitching/burning in the extremities, altered gait, diarrhoea.

Specific Risk Factors for Deficiency

Alcohol abuse.

Dietary Sources

Good Dietary Sources of Vitamin B3:

  • meat,
  • fish,
  • whole grain cereal,
  • legumes,
  • mushrooms,
  • nuts.

Vitamin B3 and the Brain

A vast array of processes and enzymes involved in every aspect of peripheral and brain cell function are dependent on niacin derived nucleotides such as nicotinamide adenine dinucleotide (NAD) and NAD phosphate (NADP). Beyond energy production, these include oxidative reactions, antioxidant protection, DNA metabolism and repair, cellular signalling events (via intracellular calcium), and the conversion of folate to its tetrahydrofolate derivative. Niacin also binds agonistically at two G protein receptors, the high affinity Niacin receptor 1 (NIACR1), responsible for the skin flush associated with high intake of niacin, and the low affinity NIACR2. Niacin receptors are distributed both peripherally in immune cells and adipose tissue, and throughout the brain. Currently established roles include modulation of inflammatory cascades and anti-atherogenic lipolysis in adipose tissue. NIACR1 receptor populations have been shown to be down-regulated in the anterior cingulate cortex of schizophrenia sufferers and upregulated in the substantia nigra of Parkinson’s disease sufferers, (a group that have low niacin levels generally) with levels correlating with poorer sleep architecture in this group. A recent case study demonstrated that 250 mg niacin administration modulated peripheral immune cell NIACR1 expression and attenuated the disturbed sleep architecture associated with Parkinson’s disease(1262).

Brain Specific Symptoms of Deficiency

Depression, anxiety, progressing to vertigo, memory loss, paranoia, psychotic symptoms, aggression (Pellagrous insanity).


Nicotinic Acid - Description from NCI Thesaurus

 

Nicotinic Acid - Description from ChemIDplus

 

Nicotinic Acid - Description from DrugBank

 

Nicotinic Acid - Description from Wikipedia

 


The supplements containing Vitamin B3

Acti Vita-miner Prenatal DHA, tabletki, 30 szt. + kapsułki, 30 szt. / (Aflofarm)Acti Vita-miner Prenatal DHA, tabletki, 30 szt. + kapsułki, 30 szt. / (Aflofarm)

Polish version

Only for Women Prenatal / Pregnancy Women's Health Women's Multivitamins TBSS ID:
Acti Vita-miner Prenatal DHA, tabletki, 30 szt. + kapsułki, 30 szt. / (Aflofarm) contains Vitamin B3 in the form of Nicotinamide.

 

Learn More (PL)
Acti Vita-miner Prenatal+DHA - suplement diety zawiera składniki uzupełniające codzienną dietę w niezbędne witaminy i minerały oraz niezbędne nienasycone kwasy tłuszczowe DHA i EPA. Jest przeznaczony dla dla kobiet w 2 i 3 trymestrze ciąży oraz karmiących piersią.
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Doppelherz Vital Tonik, płyn, 750 ml / (Queisser)Doppelherz Vital Tonik, płyn, 750 ml / (Queisser)

Polish version

Cellulite Minerals Stress / Relaxation Vitamins TBSS ID:
Doppelherz Vital Tonik, płyn, 750 ml / (Queisser) contains Vitamin B3 in the form of Nicotinamide.

 

Learn More (PL)
Doppelherz Vital Tonik - suplement diety, któreg składniki wpływają wzmacniająco na stan naczyń krwionośnych oraz wspomagają prawidłowe funkcje umysłowe. Produkt dla osób dorosłych, a także dla osób, które są narażone na stres, w sile wieku oraz mało aktywne.
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If you know of any other quality supplement that has not been yet classified by us, please contact us and we will gladly consider adding it to our catalogue.


Vitamin B3 (niacin/nicotinic acid) - References & External links

Vitamin B3 (Nicotinic Acid)

TBS Ingredient ID (TBSI ID):
Name
Vitamin B3
Synonyms:
Vitamin PP, Niacin, Pyridine-3-Carboxylic Acid, 3-Pyridinecarboxylic Acid
Chemical Formula:
C6H5NO2 or HOOC5H4N or C5H4NCOOH
Molecular Formula:
Nicotinic Acid - Molecular Formula
Classification TypeIdentifier
PubChem CID:
U.S. National Library of Medicine (PubChem)
CAS:
A proprietary registry number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society (ACS)		59-67-6
NIST:
The National Institute of Standards and Technology (NIST)
ChemIDplus:
United States National Library of Medicine - TOXNET (Toxicology Data Network).
Show: Nicotinic Acid - description from ChemIDplus
ATC code:
WHO ATC Classification System. The Anatomical Therapeutic Chemical (ATC) Classification System is used for the classification of drugs. This pharmaceutical coding system divides drugs into different groups according to the organ or system on which they act and/or their therapeutic and chemical characteristics
UNII:
FDA Substance Registration System - Unique Ingredient Identifier
NCI Thesaurus:
National Cancer Institute - NCI.
Show: Nicotinic Acid - description from NCI Thesaurus
DrugBank:
The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug data with comprehensive drug target information.
Show: Nicotinic Acid - description from DrugBank
Wikipedia:
Wikipedia, the free encyclopedia.		Niacin
Show: Nicotinic Acid - description from Wikipedia
InChI Key:
International Chemical Identifier hash (InChIKey) computed from chemical structure using the International Union of Pure and Applied Chemistry (IUPAC) standard		PVNIIMVLHYAWGP-UHFFFAOYSA-N
EC Number:
A seven-digit regulatory identifier currently assigned by the European Chemicals Agency (ECHA) known as a European Community (EC) number		200-441-0
ChEBI:
Chemical Entities of Biological Interest (ChEBI) - Dictionary of molecular entities focused on "small" chemical compounds. ChEBI is part of the EMBL-European Bioinformatics Institute.
KEGG:
Kyoto Encyclopedia of Genes and Genomes (KEGG)
ChEMBL:
An open data resource of binding, functional and ADMET bioactivity data (ChEMBL)
ECHA:
European Chemicals Agency.
DSSTox Substance ID:
United States Environmental Protection Agency (EPA).
3DMet:
3DMET is a database collecting three-dimensional structures of natural metabolites.
MeSH® ID:
Medical Subject Heading (MeSH)

Related substances

Nicotinamide

Nicotinamide

TBS Ingredient ID (TBSI ID):
Name
Nicotinamide
Synonyms:
Nikotinamid, Niacinamide, Nicotylamide, 3-Pyridinecarboxamide, Nicotinic Acid Amide, Aminicotin
Chemical Formula:
C6H6N2O
Classification TypeIdentifier
PubChem CID:
U.S. National Library of Medicine (PubChem)
InChI Key:
International Chemical Identifier hash (InChIKey) computed from chemical structure using the International Union of Pure and Applied Chemistry (IUPAC) standard		DFPAKSUCGFBDDF-UHFFFAOYSA-N
CAS:
A proprietary registry number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society (ACS)		98-92-0
NIST:
The National Institute of Standards and Technology (NIST)
ChemIDplus:
United States National Library of Medicine - TOXNET (Toxicology Data Network).
EC Number:
A seven-digit regulatory identifier currently assigned by the European Chemicals Agency (ECHA) known as a European Community (EC) number		202-713-4
ATC code:
WHO ATC Classification System. The Anatomical Therapeutic Chemical (ATC) Classification System is used for the classification of drugs. This pharmaceutical coding system divides drugs into different groups according to the organ or system on which they act and/or their therapeutic and chemical characteristics
UNII:
FDA Substance Registration System - Unique Ingredient Identifier

Beta-Nicotinamide Adenine Dinucleotide

Nicotinamide adenine dinucleotide (NAD) is a cofactor that is central to metabolism. Found in all living cells, NAD is called a dinucleotide because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine nucleobase and the other nicotinamide. NAD exists in two forms: an oxidized and reduced form, abbreviated as NAD+ and NADH respectively.

Beta-Nicotinamide Adenine Dinucleotide

TBS Ingredient ID (TBSI ID):
Name
Beta-Nicotinamide Adenine Dinucleotide
Synonyms:
Endopride
Chemical Formula:
C21H27N7O14P2
Classification TypeIdentifier
PubChem CID:
U.S. National Library of Medicine (PubChem)
InChI Key:
International Chemical Identifier hash (InChIKey) computed from chemical structure using the International Union of Pure and Applied Chemistry (IUPAC) standard		BAWFJGJZGIEFAR-UHFFFAOYSA-N
CAS:
A proprietary registry number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society (ACS)		53-84-9
NIST:
The National Institute of Standards and Technology (NIST)
ChemIDplus:
United States National Library of Medicine - TOXNET (Toxicology Data Network).
NSC Number: 20272

Nadide

Nadide is a dinucleotide of adenine and nicotinamide. It has coenzyme activity in redox reactions and also acts as a donor of ADP-ribose moieties.

Nadide

TBS Ingredient ID (TBSI ID):
Name
Nadide
Synonyms:
NAD+, Coenzyme I, Beta-NAD, Beta-NAD+, Nicotinamide Adenine Dinucleotide, Beta-Diphosphopyridine Nucleotide, Diphosphopyridine Nucleotide, Enzopride
Chemical Formula:
C21H27N7O14P2
Classification TypeIdentifier
PubChem CID:
U.S. National Library of Medicine (PubChem)
InChI Key:
International Chemical Identifier hash (InChIKey) computed from chemical structure using the International Union of Pure and Applied Chemistry (IUPAC) standard		BAWFJGJZGIEFAR-NNYOXOHSSA-N
CAS:
A proprietary registry number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society (ACS)		53-84-9
NIST:
The National Institute of Standards and Technology (NIST)
ChemIDplus:
United States National Library of Medicine - TOXNET (Toxicology Data Network).
NSC Number: 757121
EC Number:
A seven-digit regulatory identifier currently assigned by the European Chemicals Agency (ECHA) known as a European Community (EC) number		200-184-4
ECHA:
European Chemicals Agency.
DSSTox Substance ID:
United States Environmental Protection Agency (EPA).
UNII:
FDA Substance Registration System - Unique Ingredient Identifier

Triphosphopyridine Nucleotide

Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)

Triphosphopyridine Nucleotide

TBS Ingredient ID (TBSI ID):
Name
Triphosphopyridine Nucleotide
Synonyms:
NADP, NAD Phosphate, Coenzyme II, Nadide Phosphate
Chemical Formula:
C21H28N7O17P3
Classification TypeIdentifier
PubChem CID:
U.S. National Library of Medicine (PubChem)
InChI Key:
International Chemical Identifier hash (InChIKey) computed from chemical structure using the International Union of Pure and Applied Chemistry (IUPAC) standard		XJLXINKUBYWONI-NNYOXOHSSA-N
CAS:
A proprietary registry number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society (ACS)		53-59-8
NIST:
The National Institute of Standards and Technology (NIST)
ChemIDplus:
United States National Library of Medicine - TOXNET (Toxicology Data Network).
EC Number:
A seven-digit regulatory identifier currently assigned by the European Chemicals Agency (ECHA) known as a European Community (EC) number		200-178-1
ChEBI:
Chemical Entities of Biological Interest (ChEBI) - Dictionary of molecular entities focused on "small" chemical compounds. ChEBI is part of the EMBL-European Bioinformatics Institute.
ChEMBL:
An open data resource of binding, functional and ADMET bioactivity data (ChEMBL)

Dihydronicotinamide-Adenine Dinucleotide Phosphate

NADPH is the reduced form of NADP+; used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent. It has a role as a fundamental metabolite and a cofactor. It is a NAD(P)H and a NADP. It is a conjugate acid of a NADPH(4-).

Dihydronicotinamide-Adenine Dinucleotide Phosphate

TBS Ingredient ID (TBSI ID):
Name
Dihydronicotinamide-Adenine Dinucleotide Phosphate
Synonyms:
NADPH
Chemical Formula:
C21H30N7O17P3
Classification TypeIdentifier
PubChem CID:
U.S. National Library of Medicine (PubChem)
InChI Key:
International Chemical Identifier hash (InChIKey) computed from chemical structure using the International Union of Pure and Applied Chemistry (IUPAC) standard		ACFIXJIJDZMPPO-NNYOXOHSSA-N
CAS:
A proprietary registry number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society (ACS)		53-57-6
NIST:
The National Institute of Standards and Technology (NIST)
ChemIDplus:
United States National Library of Medicine - TOXNET (Toxicology Data Network).
EC Number:
A seven-digit regulatory identifier currently assigned by the European Chemicals Agency (ECHA) known as a European Community (EC) number		200-177-6
ChEBI:
Chemical Entities of Biological Interest (ChEBI) - Dictionary of molecular entities focused on "small" chemical compounds. ChEBI is part of the EMBL-European Bioinformatics Institute.
ChEMBL:
An open data resource of binding, functional and ADMET bioactivity data (ChEMBL)
UNII:
FDA Substance Registration System - Unique Ingredient Identifier

The references to scientific articles about Vitamin B3 (niacin/nicotinic acid) are not meant to imply that any products treat, cure, or diagnose any disease or human condition. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.