TOXIC OFF

TOXIC OFF – Ingredients

• Wormwood (Artemisia Absinthium)
  Wormwood has strong immunomodulatory and anti-inflammatory properties. It also is known to have anti-fungal, anti-bacterial, anti-parasitic and anti-cancer attributes. Species: Artemisia Absinthium,
  Family: Asteraceae,
  European Medicines Agency: EMA: Absinthii Herba,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH471B20,
  References:
  Digestive Health: NG, S. C.; et al. Systematic Review: The Efficacy of Herbal Therapy in Inflammatory Bowel Disease. Alimentary pharmacology & therapeutics, 2013, 38.8: 854-863. PMID:23981095, SZOPA, Agnieszka; et al. Artemisia absinthium L.-Importance in the History of Medicine, the Latest Advances in Phytochemistry and Therapeutical, Cosmetological and Culinary Uses. Plants, 2020, 9.9: 1063. PMID:32825178.
  
  
  • Artemisinin (C₁₅H₂₂O₅)
    Artemisinin: Artemisinin, Arteannuin, Artemisinine,
    PubChem CID: 68827,
    Chemical Abstracts Service: CAS: 63968-64-9,
    ChemIDplus: 63968-64-9,
    FDA Substance Registration System – Unique Ingredient Identifier: UNII: 9RMU91N5K2,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISEF9020,
    References:
    Immune: LI, Tan; et al. Anti-inflammatory and immunomodulatory mechanisms of artemisinin on contact hypersensitivity. International immunopharmacology, 2012, 12.1: 144-150. PMID:22122827.
    
• Turmeric (Curcuma Longa)
  Ease and eliminate unpleasant symptoms accompanying parasitic invasion: spasms in the gastrointestinal tract, nausea, diarrhea, headache. Curcumin is known recently to have antioxidant, anti-inflammatory, anticancer effects and, thanks to these effects, to have an important role in prevention and treatment of various illnesses ranging notably from cancer to autoimmune, neurological, cardiovascular diseases, and diabetic. Species: Curcuma Longa,
  Family: Zingiberaceae,
  European Medicines Agency: EMA: Curcumae Longae Rhizoma,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH4A7680,
  References:
  Immune: PAN, Min–Hsiung; et al. Effects of Water Extract of Curcuma Longa (L.) Roots on Immunity and Telomerase Function. Journal of Complementary and Integrative Medicine, 2017, 14.3: . PMID:28889732, JURENKA, Julie S.; et al. Anti-inflammatory Properties of Curcumin, a Major Constituent of Curcuma Longa: A Review of Preclinical and Clinical Research. Alternative medicine review, 2009, 14.2: . PMID:19594223,
  Digestive Health: PRUCKSUNAND, Chaweewan; et al. Phase II Clinical Trial on Effect of the Long Turmeric (Curcuma Longa Linn) on Healing of Peptic Ulcer. Southeast Asian journal of tropical medicine and public health, 2001, 32.1: 208-215. PMID:11485087, BUNDY, Rafe; et al. Turmeric Extract May Improve Irritable Bowel Syndrome Symptomology in Otherwise Healthy Adults: A Pilot Study. Journal of Alternative & Complementary Medicine, 2004, 10.6: 1015-1018. PMID:15673996,
  Cleansing: TELES, Amanda Mara; et al. Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity. Evidence-Based Complementary and Alternative Medicine, 2019, 2019: 8928306. PMID:30766611.
  
  
  • Curcumin (IC₂₁H₂₀O₆ or C₂₁H₂₀O₆)
    Curcumin: Curcumin, Diferuloylmethane,
    PubChem CID: 969516,
    Chemical Abstracts Service: CAS: 458-37-7,
    ChemIDplus: 458-37-7,
    FDA Substance Registration System – Unique Ingredient Identifier: UNII: IT942ZTH98,
    The Best Supplements – Unique Ingredient Identifier: TBSI ID: ISB59460,
    References:
    Immune: CATANZARO, Michele; et al. Immunomodulators Inspired by Nature: A Review on Curcumin and Echinacea. Molecules, 2018, 23.11: 2778. PMID:30373170, JURENKA, Julie S.; et al. Anti-inflammatory Properties of Curcumin, a Major Constituent of Curcuma Longa: A Review of Preclinical and Clinical Research. Alternative medicine review, 2009, 14.2: . PMID:19594223,
    Digestive Health: HOLT, Peter R.; KATZ, Seymour; KIRSHOFF, Robert Curcumin Therapy in Inflammatory Bowel Disease: A Pilot Study. Digestive diseases and sciences, 2005, 50.11: 2191-2193. PMID:16240238, HANAI, Hiroyuki; et al. Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial. Clinical Gastroenterology and Hepatology, 2006, 4.12: 1502-1506. PMID:17101300.
    
• Celery (Apium Graveolens)
  Creates a healthy alkaline environment in the intestines, in which parasites cannot live and reproduce. This protects against re-infection. Species: Apium Graveolens,
  Family: Apiaceae,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH4E9530,
  References:
  Digestive Health: HEDAYATI, Narges; et al. Beneficial effects of celery (Apium graveolens) on metabolic syndrome: A review of the existing evidences. Phytotherapy Research, 2019, 33.12: 3040-3053. PMID:31464016.
  
  
• Gotu Kola (Centella Asiatica)
  This extract suppress the reproductive system of parasites and their ability to reproduce. It also reduce the ability of parasites to attach to tissues and organs, which accelerates their excretion from the body along with eggs. Species: Centella Asiatica,
  Family: Apiaceae Mackinlayaceae,
  The Best Supplements – Unique Ingredient Identifier: TBSI ID: IH4FA6A0,
  References:
  Cleansing: BAGAVAN, A.; et al. Adulticidal and larvicidal efficacy of some medicinal plant extracts against tick, fluke and mosquitoes. Veterinary parasitology, 2009, 166.3-4: 286-292. PMID:19819626,
  Digestive Health: LI, Huibiao; et al. Ethanol extract of Centella asiatica alleviated dextran sulfate sodium-induced colitis: Restoration on mucosa barrier and gut microbiota homeostasis. Journal of Ethnopharmacology, 2021, 267: 113445. PMID:33022343, WANNASARIT, Saowanee; et al. Raft-forming gastro-retentive formulations based on Centella asiatica extract-solid dispersions for gastric ulcer treatment. European Journal of Pharmaceutical Sciences, 2020, 143: 105204. PMID:31870812.