Naber Kurt G., et al.
Research and reports in Urology, 2013
Abstract
This review evaluates 17 clinical studies from 18 selected publications concerning the safety, tolerability, and additional effects of the phytotherapeutic drug, Canephron® N (CAN, containing the medicinal plants, Centaurium erythraea, Levisticum officinale, and Rosmarinus officinalis) as standard therapy in various clinical settings. Its role in the prophylaxis and treatment of urinary tract infections in adults and in children, therapy and prophylaxis in adult patients with renal stones, treatment and prevention of urinary tract infections and other gestational diseases in pregnancy, and also its safety and tolerability. The dosage was as recommended and over a varying duration. Overall, CAN was shown to be effective in the treatment and prophylaxis of UTI compared with standard therapy, both in adults and children, and there was a reduced number of relapses. Children undergoing surgical correction of vesicoureteral reflux benefited from a prophylactic course of CAN. Ten-day add on therapy increased the rate of spontaneous elimination of kidney stones compared with standard therapy alone and may also have had a positive effect on stone prevention. Pregnant women showed earlier relief of symptoms and normalization of pyuria on additional treatment with the herbal combination. Only one adverse effect was reported (skin rash) in the 3115 patients included in this review. No teratogenic, embryotoxic, or fetotoxic effects, or negative interference with the psychological development or health of children born of mothers treated with the drug were reported. Because some of the studies were not well designed, their statistical significance remains unclear.
Keywords
Canephron® N; gestational disease; herbal remedy; urogenital disease.
| PMID: | 24400233 |
|---|---|
| DOI: | 10.2147/RRU.S39288 |
| PMCID (Free PMC Article): | PMC3826901 |
| Category: | Urinary Tract |
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- KETO Core - You probably know what ketogenic diet is – that it consists of a major change of your eating habits. It contains among others: Levisticum Officinale.
- Kidney Cleanse, 90 Veggie Caps (Now Foods) - A healthy urinary tract is essential for maintaining the body's normal fluid balance and for cleansing the body of metabolic wastes. It contains among others: Rosmarinus Officinalis.
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