Immune-enhancing Effects of Maitake (Grifola Frondosa) and Shiitake (Lentinula Edodes) Extracts.

Vetvicka Vaclav, Vetvickova Jana
Annals of translational medicine, 2014

Abstract

Background

The role of glucan in stimulation of immune reactions has been studied for several decades. In this report, we focused on the effects of orally administered glucan Maitake and Shiitake on immune reactions.

Materials and Methods

We measured phagocytosis, NK cell activity, and secretion of IL-6, IL-12, IFN-γ as well as C-reactive protein (CRP) after 14 days of oral application of tested glucans. For comparison, active hexose correlated compound (AHCC) was used in all reactions.

Results

We found significant stimulation of defense reaction. In all cases, the most active was the Maitake-Shiitake combination, with Maitake alone being the second strongest, followed by Shiitake on its own and AHCC.

Conclusions

Short-term oral application of natural immunomodulating glucans from Maitake and Shiitake mushrooms strongly stimulated both the cellular and humoral branch of immune reactions. These activities were significantly higher than those of AHCC.

Keywords

C-reactive protein (CRP); NK cells; Phagocytosis; cytokines; glucan.

The best supplements with Lentinula Edodes or Grifola Frondosa in Immune category:

• Immunity 911 - Extra Powerful Ingredients for Your Stronger Immunity -

  Immunity 911 - Advanced Immune Boster Formula Your First Line Of Defense Against Infection!

  Viruses are floating all around us, ready to filter into our body any moment completely unnoticed. It contains among others: Lentinula Edodes, Grifola Frondosa.
• Beta-1,3/1,6-D-Glucan, 100 mg, 90 Veggie Caps (Now Foods) - NOW Beta-1,3/1,6-D-Glucan (Beta-Glucan) is a bioactive carbohydrate derived from the cell wall of Saccharomyces cerevisiae, commonly known as Baker's yeast. It contains among others: Grifola Frondosa.

Articles similar to "Immune-enhancing Effects of Maitake (Grifola Frondosa) and Shiitake (Lentinula Edodes) Extracts."

• The significance of Lentinula Edodes for Immune: Consuming Lentinula Edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults. ( Mushrooms are widely cited for their medicinal qualities, yet very few human intervention studies have been done using contemporary guidelines... Regular L. edodes consumption resulted in improved immunity, as seen by improved cell proliferation and activation and increased sIgA production. The changes observed in cytokine and serum CRP levels suggest that these improvements occurred under conditions that were less inflammatory than those that existed before consumption. )
• The role of Lentinula Edodes in Immune: Preparation of Lentinula Edodes Polysaccharide-Calcium Complex and Its Immunoactivity. (Polysaccharide is a major bioactive component of mushrooms... Regular L. edodes consumption resulted in improved immunity, as seen by improved cell proliferation and activation and increased sIgA production. The changes observed in cytokine and serum CRP levels suggest that these improvements occurred under conditions that were less inflammatory than those that existed before consumption. )
• The significance of Grifola Frondosa for Immune: Structural Elucidation and Immune-Enhancing Effects of Novel Polysaccharide From Grifola frondosa. (Beta-glucan (β-glucan) is a macromolecule structure where glucose unit has bonded through β-glycosidic bond at 1 and 3 positions... Regular L. edodes consumption resulted in improved immunity, as seen by improved cell proliferation and activation and increased sIgA production. The changes observed in cytokine and serum CRP levels suggest that these improvements occurred under conditions that were less inflammatory than those that existed before consumption. )

Previous article

Preparation of Lentinula Edodes Polysaccharide-Calcium Complex and Its Immunoactivity.

Next article

Structural Elucidation and Immune-Enhancing Effects of Novel Polysaccharide From Grifola frondosa.