Magrone Thea, et al.
Current Drug Targets-Immune, Endocrine & Metabolic Disorders, 2017
Abstract
Background
Nickel (Ni) is a metal largely present in the environment and prolonged exposure to it may lead to multiple pathological conditions in human subjects. Among these, the most frequent is allergic contact dermatitis.
Methods
Peripheral blood mononuclear cells isolated from 25 patients with Ni-dependent contact dermatitis were evaluated in terms of cytokine release and nitric oxide (NO) production in the presence or absence of two doses (3 and 5 µg, respectively) of polyphenols.
Results
Polyphenols were able to reduce the increased release of interferon-γ and interleukin (IL)-4, while maintaining the equilibrium between IL-10 and IL-17. At the same time, exaggerated release of NO was reduced by polyphenol supplementation.
Conclusion
In view of their anti-inflammatory activities, polyphenols may represent a potential therapeutic tool to treat Ni-sensitized patients.
Keywords
Allergic contact dermatitis; interleukin; nickel; nitric oxide; peripheral blood mononuclear cells; polyphenols.
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
| PMID: | 28982342 |
|---|---|
| DOI: | 10.2174/1871530317666171003161314 |
| Category: | Allergy / Immune |
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