Annona Muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities.

Moghadamtousi Soheil Zorofchian, et al.
International journal of molecular sciences, 2015

Abstract

Annona muricata is a member of the Annonaceae family and is a fruit tree with a long history of traditional use. A. muricata, also known as soursop, graviola and guanabana, is an evergreen plant that is mostly distributed in tropical and subtropical regions of the world. The fruits of A. muricata are extensively used to prepare syrups, candies, beverages, ice creams and shakes. A wide array of ethnomedicinal activities is contributed to different parts of A. muricata, and indigenous communities in Africa and South America extensively use this plant in their folk medicine. Numerous investigations have substantiated these activities, including anticancer, anticonvulsant, anti-arthritic, antiparasitic, antimalarial, hepatoprotective and antidiabetic activities. Phytochemical studies reveal that annonaceous acetogenins are the major constituents of A. muricata. More than 100 annonaceous acetogenins have been isolated from leaves, barks, seeds, roots and fruits of A. muricata. In view of the immense studies on A. muricata, this review strives to unite available information regarding its phytochemistry, traditional uses and biological activities.

Keywords

Annona muricata; acetogenins; annonaceae; bioactive compounds; biological activity; fruit tree; natural products.

Figures

Annona muricata

(A) Annona muricata L.; the appearance of the (B) leaves; (C) flowers and (D) fruits.

Chemical structures of the major compounds isolated from Annona muricata

Chemical structures of the major compounds isolated from Annona muricata.

Chemical structures of the major compounds isolated from Annona muricata (2)

Chemical structures of the major compounds isolated from Annona muricata. (2)

Chemical structures of the major compounds isolated from Annona muricata (3)

Chemical structures of the major compounds isolated from Annona muricata. (3)

Chemical structures of the major compounds isolated from Annona muricata (4)

Chemical structures of the major compounds isolated from Annona muricata. (4)

Chemical structures of the major compounds isolated from Annona muricata (5)

Chemical structures of the major compounds isolated from Annona muricata. (5)

Chemical structures of the major compounds isolated from Annona muricata (6)

Chemical structures of the major compounds isolated from Annona muricata. (6)

Chemical structures of the major compounds isolated from Annona muricata (7)

Chemical structures of the major compounds isolated from Annona muricata. (7)

Chemical structures of the major compounds isolated from Annona muricata (8)

Chemical structures of the major compounds isolated from Annona muricata. (8)

PMID:26184167
DOI:10.3390/ijms160715625
PMCID (Free PMC Article):PMC4519917
Category:General properties of Annona Muricata

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